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Synthesis and characterization of poly(lactic acid)-modified superparamagnetic iron oxide nanoparticles

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Abstract

Poly(ethylene glycol) (PEG)- and poly(vinylpyrrolidone) (PVP)-coated superparamagnetic iron oxide nanoparticles (SPIONs) with the particle size of 8.0 ± 1.4 nm were synthesized by thermal decomposition of Fe(acac)3 in 15 g PEG containing 0.3 g PVP (PEG/PVP-SPIONs) and then were coated further with poly(lactic acid) (PLA/PEG/PVP-SPIONs). The PEG/PVP-SPIONs and PLA/PEG/PVP-SPIONs were superparamagnetic with the saturation magnetization of 54.5 and 46.2 emu/g measured by the superconducting quantum interference device, respectively. The hydrodynamic diameter of PEG/PVP-SPIONs in deionized water was 18.8 nm, which increased to 52.4 nm after coated with PLA. The zeta potential of PEG/PVP-SPIONs was 0 mV, which changed to −11.3 mV after coated with PLA. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses indicated that PLA was attached to the PEG/PVP-SPIONs. Thermogravimetric analyses showed that the amount of PLA coated on PEG/PVP-SPIONs was about 9.6 wt%. With high magnetic properties and good dispersibility in aqueous media, the uniform-sized PLA/PEG/PVP-SPIONs nanoparticles have potential in biomedical application.

Graphical Abstract

The synthesis and coating of the SPIONs.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 51162003).

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Authors and Affiliations

  1. State Key Laboratory Breeding Base of Nonferrous Metals and Specific Materials Processing, School of Materials Science and Engineering, Guilin University of Technology, Jian Gan Road 12, Guilin, 541004, People’s Republic of China

    Gao Yang, Baolin Zhang, Jun Wang, Ming Wang, Songbo Xie & Xuan Li

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  1. Gao Yang
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  2. Baolin Zhang
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  3. Jun Wang
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  4. Ming Wang
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  5. Songbo Xie
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  6. Xuan Li
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Correspondence to Baolin Zhang.

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Yang, G., Zhang, B., Wang, J. et al. Synthesis and characterization of poly(lactic acid)-modified superparamagnetic iron oxide nanoparticles. J Sol-Gel Sci Technol 77, 335–341 (2016). https://doi.org/10.1007/s10971-015-3858-2

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  • DOI: https://doi.org/10.1007/s10971-015-3858-2

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