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Synthesis and characterisation of Gossypium hirsutum seeds extract nanoencapsulated in silica microparticles

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Abstract

Nanoencapsulation of pharmaceutically active natural compounds into porous systems through sol–gel method leads to new drug delivery materials with sustained release behaviour of the entrapped pharmaceuticals. Properties of inorganic sol–gel-derived silica microparticles loaded with cotton (Gossypium hirsutum) seeds extract are reported. Xerogels obtained by heat or freeze drying were investigated by X-ray diffraction, dynamic light scattering, differential thermal analysis (DTA)/thermogravimetric analysis (TGA), UV–Vis and fluorescence spectroscopy. Effects of drying process on both silica particles and plant extract were evaluated. In vitro release was studied in release media with pH 1.1 and 7.4. The investigated biocomposite systems display a biphasic release profile wherein the diffusion prevails over the dissolution.

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Acknowledgments

This work was possible with the financial support of the Sectoral Operational Programme for Human Resources Development 2007–2013, co-financed by the European Social Fund, under the project number POSDRU/159/1.5/S/132400.

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Authors and Affiliations

  1. Faculty of Physics and Institute of Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania

    C. V. Moraru, K. Magyari, M. Tamasan, S. Suarasan & S. Simon

  2. Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

    C. V. Moraru, D. Muntean, L. Vlase & F. Loghin

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  1. C. V. Moraru
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  2. K. Magyari
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Correspondence to S. Simon.

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Moraru, C.V., Magyari, K., Tamasan, M. et al. Synthesis and characterisation of Gossypium hirsutum seeds extract nanoencapsulated in silica microparticles. J Sol-Gel Sci Technol 77, 57–68 (2016). https://doi.org/10.1007/s10971-015-3828-8

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  • DOI: https://doi.org/10.1007/s10971-015-3828-8

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