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Preparation and validation of [67Ga]Ga-phytate kit and Monte Carlo dosimetry: an effort toward developing an impressive lymphoscintigraphy tracer

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Abstract

Radiocolloides are essential for the detection of metastatic lymph nodes in breast cancer. In this study [67Ga]Ga-phytate, as an long-lived alternative for [99mTc]Tc-radiocolloids was prepared. "Standard" labeling conditions for [67Ga]Ga-phytate preparation (95–100 °C, 30 min, 0.5 mg phytic acid, aqueous solutions) has been adopted (radiochemical purity: > 98 ± 2% ITLC, specific activity: 0.9–1.1 GBq/mmol). The complex is mainly cleared from the blood pool through the liver by hepatic system (> 90%) and a small percentage (< 7–8%) through the kidneys by renal excretion. Dosimetric simulations showed that the final radiopharmaceutical doses are safe for clinical administrations.

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Authors and Affiliations

  1. Department of Radiation Medical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Zeinab Bayat & Elham Saeedzadeh

  2. Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Nasim Vahidfar, Saeed Farzenefar & Yalda Salehi

  3. Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Mahdi Sadeghi

  4. Radioisotope & Radiopharmaceutical Department, Radiation Application Faculty, Nuclear Science & Technology Research Institute (NSTRI), Tehran, Iran

    Fariba Johari Daha

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  1. Zeinab Bayat
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  2. Elham Saeedzadeh
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  3. Nasim Vahidfar
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  5. Saeed Farzenefar
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Correspondence to Nasim Vahidfar.

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Bayat, Z., Saeedzadeh, E., Vahidfar, N. et al. Preparation and validation of [67Ga]Ga-phytate kit and Monte Carlo dosimetry: an effort toward developing an impressive lymphoscintigraphy tracer. J Radioanal Nucl Chem 331, 691–700 (2022). https://doi.org/10.1007/s10967-021-08183-z

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  • DOI: https://doi.org/10.1007/s10967-021-08183-z

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