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Development and validation of a robust analytical method for the determination of 51Cr in blood samples by liquid scintillation counting (LSC)

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Abstract

A robust analytical method for the measurement of 51Cr in blood samples in routine mode by means of liquid scintillation count was developed and validated with spiked blood samples from different subjects. Prior to the measurements, the samples were microwave digested in order to eliminate the matrix influence. Figures of merits, such as sensitivity, limits of detection, precision and accuracy were studied and confirmed the capability of the method to determine 51Cr in blood samples as low as 0.5 Bq g−1 of sample.

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References

  1. Chechev VP, Kuzmenko NK (2016) Decay Data Evaluation Project (DDEP): updated decay data evaluations for Na-24, Sc-46, Cr-51, Mn-54, Co-57, Fe-59, Y-88, Au-198. Appl Radiat Isot 109:139–145

    Article  CAS  Google Scholar 

  2. de Almeida MCM, Iwahara A, Poledna R, da Silva CJ, Delgado JU (2007) Absolute disintegration rate and 320 keV gamma-ray emission probability of Cr-51. Nucl Instrum Methods Phy Res Sect A 580:165–168

    Article  Google Scholar 

  3. Fuglsang S, Henriksen U, Hansen H, Bendtsen F, Henriksen J (2016) Gamma-variate plasma clearance versus urinary plasma clearance of 51 Cr-EDTA in patients with cirrhosis with and without fluid retention. Clin Physiol Funct Imaging. doi:10.1111/cpf.12336

    Google Scholar 

  4. Delgado R, Sanders TM, Bloor CM (1975) Renal blood flow distribution during steady-state exercise and exhaustion in conscious dogs. J Appl Physiol 39:475–478

    CAS  Google Scholar 

  5. Vandermeulen E, De Sadeleer C, Piepsz A, Ham HR, Dobbeleir AA, Vermeire ST, Van Hoek IM, Daminet SV, Slegers G, Peremans KY (2010) Determination of optimal sampling times for a two blood sample clearance method using Cr-51-EDTA in cats. J. Feline Med Surg 12:577–583

    Article  Google Scholar 

  6. Shoji M, Kondo T, Honoki H, Nakajima T, Muraguchi A, Saito M (2007) Investigation of monitoring for internal exposure by urine bioassay in a biomedical research facility. Radiat Prot Dosimetry 127:456–460

    Article  CAS  Google Scholar 

  7. ICRP Publication 30. Part 2.1980 Limits for Intakes of Radionuclides by Workers Pergamon Press Oxford

  8. Hermanne A, Takacs S, Adam-Rebeles R, Tarkanyi F, Takacs MP (2013) New measurements and evaluation of database for deuteron induced reaction on Ni up to 50 MeV. Nucl Instrum Methods Phys Res Sect B 299:8–23

    Article  CAS  Google Scholar 

  9. Moreira DS, Koskinas MF, Yamazaki IM, Dias MS (2010) Determination of Cr-51 and Am-241 X-ray and gamma-ray emission probabilities per decay. Appl Radiat Isot 68:596–599

    Article  CAS  Google Scholar 

  10. Solieman AHM, Al-Abyad M, Ditroi F, Saleh ZA (2016) Experimental and theoretical study for the production of Cr-51 using p, d, He-3 and He-4 projectiles on V, Ti and Cr targets. Nucl Instrum Methods Phys Res Sect B 366:19–27

    Article  CAS  Google Scholar 

  11. Kikunaga H, Takamiya K, Hirose K, Ohtsuki T (2015) Comparison of the decay constants of Cr-51 with metal, oxide, and chromate chemical states. J Radioanal Nucl Chem 303:1581–1583

    Article  CAS  Google Scholar 

  12. Sakita GZ, Meira DC, Bremer Neto H, Cyrino JEP, Abdalla AL (2015) Chromium oxide ((Cr2O3)-Cr-51) used as biological marker was not absorbed by fish. Arquivo Brasileiro De Medicina Veterinaria E Zootecnia 67:755–762

    Article  Google Scholar 

  13. Bobin C, Thiam C, Chauvenet B, Bouchard J (2012) On the stochastic dependence between photomultipliers in the TDCR method. Appl Radiat Isot 70:770–780

    Article  CAS  Google Scholar 

  14. Carles AG, Gunther E, Malonda AG (2006) The photoionization-reduced energy in LSC. Appl Radiat Isot 64:43–54

    Article  Google Scholar 

  15. Wanke C, Kossert K, Naehle OJ (2012) Investigations on TDCR measurements with the HIDEX 300 SL using a free parameter model. Appl Radiat Isot 70:2176–2183

    Article  CAS  Google Scholar 

  16. Wisser S, Frenzel E, Dittmer M (2006) Innovative procedure for the determination of gross-alpha/gross-beta activities in drinking water. Appl Radiat Isot 64:368–372

    Article  CAS  Google Scholar 

  17. Freiser H (1992) Concept calculaton in analytical chemistry. CRS Press, Boca Raton

    Google Scholar 

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Acknowledgments

The author would like to thank Dr. Schläger and Dr. Kummerle for the measurements with WBC and γ-spectrometry, respectively, as well as for their valuable discussions. The help of the radioanalytical laboratory staff was also very much appreciated.

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Authors and Affiliations

  1. Division of Safety and Radiation Protection, Forschungszentrum Jülich GmbH, 52428, Jülich, Germany

    Myroslav V. Zoriy, M. Froning & P. Hill

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  1. Myroslav V. Zoriy
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  2. M. Froning
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  3. P. Hill
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Correspondence to Myroslav V. Zoriy.

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Zoriy, M.V., Froning, M. & Hill, P. Development and validation of a robust analytical method for the determination of 51Cr in blood samples by liquid scintillation counting (LSC). J Radioanal Nucl Chem 310, 1299–1302 (2016). https://doi.org/10.1007/s10967-016-4999-7

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  • DOI: https://doi.org/10.1007/s10967-016-4999-7

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