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Irradiation parameters play a crucial role in the (n, γ) production of 170Tm suitable for clinical use in bone pain palliation

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Abstract

While neutron activation of natural Tm2O3 is the convenient strategy for producing 170Tm for use in palliative care of painful bone metastases, the coproduction of 171Tm (t ½ = 1.92 years) is as an impediment towards its clinical utility. The production strategy has been optimized to obtain 170Tm with adequate specific activity and radionuclidic purity. Preliminary clinical studies carried out using the 170Tm-labeled ethylenediaminetetramethylene phosphonic acid (170Tm-EDTMP) showed site specific localization of the radiopharmaceutical in skeleton with preferential accumulation in metastatic lesions along with almost no accumulation in non-target organs, a distribution pattern comparable to that of 99mTc-labeled methylene diphosphonate (99mTc-MDP).

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Acknowledgments

Research at the Bhabha Atomic Research Centre is part of the ongoing activities of the Department of Atomic Energy, India and is fully supported by government funding. The authors are thankful to Dr. K. L. Ramakumar, Director, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre for his valuable support to the Isotope Program. The authors gratefully acknowledge Dr. S.V. Thakare and Mr. K. C. Jagadeesan of Isotope Production and Applications Division, Bhabha Atomic Research Centre, for arranging the irradiation of Tm2O3 targets in reactor. The authors also sincerely acknowledge Dr. Tapas Das, Radiopharmaceutical Chemistry Section, Bhabha Atomic Research Centre for his efforts in formulating cold kits of EDTMP used for preparation of 170Tm-EDTMP at hospital radiopharmacy.

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    Authors and Affiliations

    1. Isotope Production and Applications Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India

      Mohammed Sahiralamkhan, Rubel Chakravarty, Sudipta Chakraborty & Ashutosh Dash

    2. Nuclear Medicine and PET Services, Comprehensive Cancer Care Centre, Kovai Medical Centre and Hospital, Coimbatore, 641 014, India

      K. K. Kamaleshwaran & Ajit Shinto

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    1. Mohammed Sahiralamkhan
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    2. Rubel Chakravarty
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    3. Sudipta Chakraborty
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    4. K. K. Kamaleshwaran
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    5. Ajit Shinto
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    6. Ashutosh Dash
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    Corresponding authors

    Correspondence to Sudipta Chakraborty or Ashutosh Dash.

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    Mohammed Sahiralamkhan and Rubel Chakravarty have contributed equally to this work.

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    Sahiralamkhan, M., Chakravarty, R., Chakraborty, S. et al. Irradiation parameters play a crucial role in the (n, γ) production of 170Tm suitable for clinical use in bone pain palliation. J Radioanal Nucl Chem 307, 1105–1113 (2016). https://doi.org/10.1007/s10967-015-4323-y

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