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Automated production and quality testing of [18F]labeled radiotracers using the BG75 system

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Abstract

The simplification and automation of clinical PET radiotracer production, from isotope production to quality control, can streamline the current manufacturing workflow and, at the same time minimize the investment needed. In this article we present pre-clinical and clinical results showing the feasibility for manufacture of [18F]fluoride labeled radiotracers such as [18F]FDG, [18F]NaF and [18F]FMISO under automated conditions using the BG75 system.

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Authors and Affiliations

  1. ABT Molecular Imaging Inc., R & D, 3024 Topside Business Park Dr, Louisville, TN, 37777, USA

    Atilio Anzellotti, Jim Bailey, Doug Ferguson, Aaron McFarland & Clive Brown-Proctor

  2. Nuclear Medicine Unit, “Sveta Marina” University Hospital, Varna, Bulgaria

    Pavel Bochev

  3. Diagnostic Treatment Center of the International Institute of Biological Systems, 43 Karla Marksa str., Pesochniy settl., 197758, St. Petersburg, Russia

    Georgiy Andreev

  4. Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA

    Vibhudutta Awasthi

Authors
  1. Atilio Anzellotti
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  2. Jim Bailey
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  3. Doug Ferguson
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  4. Aaron McFarland
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  5. Pavel Bochev
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  6. Georgiy Andreev
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  7. Vibhudutta Awasthi
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  8. Clive Brown-Proctor
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Correspondence to Atilio Anzellotti.

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Anzellotti, A., Bailey, J., Ferguson, D. et al. Automated production and quality testing of [18F]labeled radiotracers using the BG75 system. J Radioanal Nucl Chem 305, 387–401 (2015). https://doi.org/10.1007/s10967-015-4045-1

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  • DOI: https://doi.org/10.1007/s10967-015-4045-1

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