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Development of radiolabeled radachlorin complex as a possible tumor targeting agent

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Abstract

Developing radiolabeled tetrahydropyrrole complexes for ultimate dual-purpose imaging as well as dual-therapeutic modalities was of our interests. [67Ga] labeled radachlorin was prepared followed by stability tests, partition coefficient determination as well as biodistribution studies in wild type rodents using scarification and SPECT imaging. However, the results showed high and prolonged uptake of the labeled compound in many organs that the potential of the labeled compound for diagnostic proposal is weak.

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References

  1. Kochneva EV, Filonenko EV, Vakulovskaya EG, Scherbakova EG, Seliverstov OV, Markichev NA, Reshetnickov AV (2010) Photosensitizer radachlorin®: skin cancer PDT phase II clinical trials. Photodiagnosis Photodyn Ther 7(4):258–267

    Article  CAS  Google Scholar 

  2. Bae SM, Kim YW, Lee JM, Namkoong SE, Han SJ, Kim JK, Lee CH, Chun HJ, Jin HS, Ahn WS (2004) Photodynamic effects of radachlorin on cervical cancer cells. Cancer Res Treat 36(6):389–394

    Article  Google Scholar 

  3. Filonenko EV, Sokolov VV, Chissov VI, Lukyanets EA, Vorozhtsov GN (2008) Photodynamic therapy of early esophageal cancer. Photodiagnosis Photodyn Ther 5(3):187–190

    Article  Google Scholar 

  4. Lee JY, Diaz RR, Cho KS, Lim MS, Chung JS, Kim WT, Ham WS, Choi YD (2013) Efficacy and safety of photodynamic therapy for recurrent, high grade nonmuscle invasive bladder cancer refractory or intolerant to Bacille Calmette–Guérin immunotherapy. J Urol 190(4):1192–1199

    Article  Google Scholar 

  5. Ji W, Yoo JW, Bae EK, Lee JH, Choi CM (2013) The effect of Radachlorin® PDT in advanced NSCLC: a pilot study. Photodiagnosis Photodyn Ther 10(2):120–126

    Article  CAS  Google Scholar 

  6. Hwang H, Biswas R, Chung PS, Ahn JC (2013) Modulation of EGFR and ROS induced cytochrome c release by combination of photodynamic therapy and carboplatin in human cultured head and neck cancer cells and tumor xenograft in nude mice. J Photochem Photobiol B 5(128):70–77

    Article  Google Scholar 

  7. Biswas R, Chung PS, Moon JH, Lee SH, Ahn JC (2014) Carboplatin synergistically triggers the efficacy of photodynamic therapy via caspase 3-, 8-, and 12-dependent pathways in human anaplastic thyroid cancer cells. Lasers Med Sci 29(3):995–1007

    Article  Google Scholar 

  8. Selman SH, Hampton JA, Morgan AR (1993) Copper benzochlorin, a novel photosensitizer for photodynamic therapy: effects on a transplantable urothelial tumor. J Photochem Photobiol 57(4):681–685

    Article  CAS  Google Scholar 

  9. Oschner M (1997) Photophysical and photobiological processes in the photodynamic therapy of tumours. J Photochem Photobiol B 39(1):1–18

    Article  Google Scholar 

  10. Vahidfar N, Jalilian AR, Fazaeli Y, Bahrami-Samani A, Beiki D, Khalaj A (2014) Preparation of a 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin complex as a possible therapeutic agent, Iran. J Nucl Med. (in press)

  11. Vahidfar N, Jalilian AR, Fazaeli Y, Bahrami-Samani A, Beiki D, Khalaj A (2014) Radiosynthesis and biological evaluation of holmium-166 labeled methoxylated porphyrins as possible therapeutic agents. J Radioanal Nucl Chem 301:269–276

    Article  CAS  Google Scholar 

  12. Vahidfar N, Jalilian AR, Fazaeli Y, Aghanejad A, Bahrami-Samani A, Alirezapour B, Erfani M, Beiki D, Khalaj A (2014) Development of radiolanthanide labeled porphyrin complexes as possible therapeutic agents in beast carcinoma xenografts. Radiochim Acta. doi 10.1515/ract-2014-2167

  13. EU patent No. 1380295 for Belgium, Switzerland, Germany, France, Republic of Ireland, Italy, The Netherlands, Sweden, Slovenia; Hungary (application No. P 04 00298), Slovakia (application No. 1348-2003), Norway (No. 327751), UK (No. GB2389531), Australia (No. 2001108397), New Zealand (No. 528237), South Africa (No. 2003/8407)

  14. Josefsen LB, Boyle RW (2008) Photodynamic therapy and the development of metal-based photosensitisers. Metal-Based Drugs 2008(276109). doi:10.1155/2008/276109

  15. Fazaeli Y, Jalilian AR, Amini MM, Aboudzadeh M, Feizi S, Rahiminezhad A, Yousefi K (2013) Preparation, nano purification, quality control and labeling optimization of [64Cu]-5, 10, 15, 20-tetrakis (penta fluoro phenyl) porphyrin complex as a possible imaging agent. J Radioanal Nucl Chem 295:255–263

    Article  CAS  Google Scholar 

  16. United States Pharmacopoeia (2005) 28 NF 23, p 1009

  17. United States Pharmacopoeia (2005) 28NF 23, p 1895

  18. http://radapharma.com/bremachlorin

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Authors and Affiliations

  1. Radiopharmacy Research Group, Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Box 14395-836, Tehran, Iran

    Yousef Fazaeli, Amir R. Jalilian, Tahereh Firouzyar, Sedigheh Moradkhani & Abbas Majdabadi

  2. Department of Chemistry, Faculty of Science, Central Tehran Branch, Islamic Azad University, Shahrak-E- Gharb, Iran

    Fatemeh Rezaee & Azar Bagheri

Authors
  1. Yousef Fazaeli
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  2. Amir R. Jalilian
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  3. Fatemeh Rezaee
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  4. Tahereh Firouzyar
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  5. Sedigheh Moradkhani
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  6. Azar Bagheri
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  7. Abbas Majdabadi
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Correspondence to Amir R. Jalilian.

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Fazaeli, Y., Jalilian, A.R., Rezaee, F. et al. Development of radiolabeled radachlorin complex as a possible tumor targeting agent. J Radioanal Nucl Chem 303, 1695–1701 (2015). https://doi.org/10.1007/s10967-014-3645-5

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  • DOI: https://doi.org/10.1007/s10967-014-3645-5

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