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Formation of semiquinone radical anion and free radical scavenging reactions of plumbagin: a pulse radiolysis study

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Abstract

Kinetics and mechanism of scavenging of reducing free radicals by plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) are studied using pulse radiolysis technique. It scavenged superoxide radical, hydroxyethyl radical and hydrated electron with bimolecular rate constants of 8.9 × 107, 2.3 × 109 and 1.6 × 1010 M−1 s−1, respectively in aqueous-alcohol medium. Plumbagin also scavenged linoleic acid peroxyl radical and tyrosyl radical with bimolecular rate constants of 1.0 × 108 and 7.0 × 106 M−1 s−1, respectively. Further, redox properties of plumbagin and its transients are studied using standard redox couples and cyclic voltammetry.

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Acknowledgments

Authors wish to thank Dr. Shilpa Tawade for the assistance with cyclic voltammetric measurements. We also thank the reviewers for some useful changes in the manuscript.

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Authors and Affiliations

  1. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India

    Ravi Joshi

  2. Bioorganic Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India

    R. Gangabhagirathi

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  1. Ravi Joshi
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  2. R. Gangabhagirathi
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Correspondence to Ravi Joshi.

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Joshi, R., Gangabhagirathi, R. Formation of semiquinone radical anion and free radical scavenging reactions of plumbagin: a pulse radiolysis study. J Radioanal Nucl Chem 303, 919–924 (2015). https://doi.org/10.1007/s10967-014-3501-7

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  • DOI: https://doi.org/10.1007/s10967-014-3501-7

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