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Development of multiple-elution cartridge-based radioisotope concentrator device for increasing the 99mTc and 188Re concentration and the effectiveness of 99mTc/99Mo utilisation

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Abstract

A self-shielded, sterile and cartridge-based radioisotope concentrator device coupled to 99mTc/188Re generators to increase the 99mTc/188Re-concentration of the generator eluate was developed based on new aminoalkyl-functionalized silica sorbent which conditionally catches and release 99mTc/188Re to concentrate the daughter nuclide of the generator eluates. The cartridge can be used for multiple elutions with an overall concentration factor of >100 and daughter nuclide recovery yield of >85 %. This device can be used for 10 days extension of 99mTc-generator life-time, saving about 20 % of the generator activity and for “early” generator-elution programs, under which the generator is eluted at an optimized build-up time for increasing the effectiveness of 99mTc/99Mo utilisation.

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References

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Authors and Affiliations

  1. Cyclopharm Ltd, Lucas Heights, Nsw, Australia

    Van So Le, Nabil Morcos & Zac Bogulski

  2. MEDISOTEC, Gymea, Nsw, Australia

    Van So Le

Authors
  1. Van So Le
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  2. Nabil Morcos
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  3. Zac Bogulski
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Correspondence to Van So Le.

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Le, V.S., Morcos, N. & Bogulski, Z. Development of multiple-elution cartridge-based radioisotope concentrator device for increasing the 99mTc and 188Re concentration and the effectiveness of 99mTc/99Mo utilisation. J Radioanal Nucl Chem 303, 1173–1178 (2015). https://doi.org/10.1007/s10967-014-3439-9

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  • DOI: https://doi.org/10.1007/s10967-014-3439-9

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