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Magnetic nanoparticle-conjugated and radioiodinated-DESG: in vitro and in vivo efficiency investigation

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Abstract

The purpose of this work is to combine magnetite nanoparticles with radioiodinated diethylstilbestrol-glucuronide (DESG) to get a prostate cancer agent. Magnetically targeted drug delivery by particulate carriers is an efficient method of delivering drugs to localized and targeted disease sites, such as tumors. Estrogen glucuronide derivative; DESG was synthesized which is specific for beta glucuronidase enzyme consisting tumor cells and conjugated with iron oxide nanoparticles (NP) and radioiodinated with 125/131I to evaluate in vitro/in vivo radiopharmaceutical potential of NP conjugated DESG (NP-DESG) and magnetic field applied NP-DESG (MNP-DESG). According to cell culture studies, incorporation ratios of MNP-DESG were higher in MCF7 cells than A549 and Caco2 cells. Biodistribution experiments were verified that the range of the breast/blood and breast/muscle ratios was approximately between 1.82 and 10.10 in 240 min for ER unsaturated studies. The results are promising for targeted therapy of both estrogen receptor and enzyme β-glucuronidase rich cancers.

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Acknowledgments

Authors thank to Ege University Scientific Research Fund with the Project Number 2009 NBE001 for the financial support.

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Authors and Affiliations

  1. Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, 35100, Izmir, Turkey

    Tayfun Yılmaz, Perihan Unak, F. Zumrut Biber Muftuler, E. Ilker Medine, Cigdem Ichedef & Ayfer Yurt Kilcar

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  1. Tayfun Yılmaz
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  2. Perihan Unak
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  3. F. Zumrut Biber Muftuler
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  4. E. Ilker Medine
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  5. Cigdem Ichedef
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  6. Ayfer Yurt Kilcar
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Correspondence to Perihan Unak.

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Yılmaz, T., Unak, P., Muftuler, F.Z.B. et al. Magnetic nanoparticle-conjugated and radioiodinated-DESG: in vitro and in vivo efficiency investigation. J Radioanal Nucl Chem 303, 63–69 (2015). https://doi.org/10.1007/s10967-014-3329-1

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  • DOI: https://doi.org/10.1007/s10967-014-3329-1

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