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Measurement and Correlation of Solubility of Nitrendipine in Supercritical Carbon Dioxide With and Without Ethanol Cosolvent

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Abstract

The solubilities of nitrendipine in supercritical carbon dioxide (ScCO2) and in the presence of 1, 3, 5, and 7 mol.% ethanol, were measured at 308, 318, and 328 K over a pressure range of 8–20 MPa. The experimental results reveal that the solubility increased with increasing pressure; the effect of temperature was more complex with or without cosolvent. The solubilities obtained in pure ScCO2 are relatively low, and they were successfully correlated by two semi-empirical models (Chrastil, Sung and Shim (SS) models). The solubility is increased significantly with ethanol as cosolvent, and these data were also correlated well using the modified Méndez-Santiago and Teja (M-ST) models.

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Acknowledgments

The authors acknowledge the funding provided by the Natural Science foundation of China (Project 21176032).

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Authors and Affiliations

  1. College of Environmental and Chemical Engineering, Dalian University, Dalian, China

    Shiping Zhan, Liyun Cui, Qicheng Zhao, Li Chen, Jingchang Wang, Shuhua Chen & Shiqiang Ding

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  1. Shiping Zhan
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  2. Liyun Cui
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  3. Qicheng Zhao
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  4. Li Chen
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  5. Jingchang Wang
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  6. Shuhua Chen
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  7. Shiqiang Ding
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Correspondence to Shiping Zhan.

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Zhan, S., Cui, L., Zhao, Q. et al. Measurement and Correlation of Solubility of Nitrendipine in Supercritical Carbon Dioxide With and Without Ethanol Cosolvent. J Solution Chem 44, 1–15 (2015). https://doi.org/10.1007/s10953-014-0262-4

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  • DOI: https://doi.org/10.1007/s10953-014-0262-4

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