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Zn-MOF: an efficient drug delivery platform for the encapsulation and releasing of Imatinib Mesylate

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Abstract

Mesoporous Zn2(BDC)2(DABCO)-MOF (BDC = 1,4-benzenedicarboxilic acid, and DABCO = diazabicyclooctane) was synthesized via ball-milling and employed as a good and efficient platform for targeted drug delivery. Imatinib mesylate (IM) was encapsulated in Zn-MOF and IM@Zn-MOF characterized using different technique including X-ray powder diffraction, field emission scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, inductively coupled plasma, Brunauer-Emmett-Teller surface area analysis. The result showed that small molecules of the IM successfully were encapsulated inside of the Zn-MOF. Releasing of drug-loaded Zn-MOF was studied by UV–vis spectroscopy at 240 nm at in vitro condition in HCl (0.1N) and PBS buffer. Rapid release of IM occurs upon hydrolytic decomposition of MOF in dissolution media.

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Acknowledgements

The authors gratefully acknowledge from Science and Research Branch, Islamic Azad University for partial financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Science and Research Branch, Islamic Azad University, 1477893855, Tehran, Iran

    Erfan Khadem Arabbaghi, Javad Mokhtari & Armaghan Khosravi

  2. Department of Chemistry, Research Laboratory of Green Organic Synthesis & Polymers, Iran University of Science and Technology, P.O. Box 16846-13114, Tehran, Iran

    Mohammad Reza Naimi-Jamal

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  1. Erfan Khadem Arabbaghi
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  2. Javad Mokhtari
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Arabbaghi, E.K., Mokhtari, J., Naimi-Jamal, M.R. et al. Zn-MOF: an efficient drug delivery platform for the encapsulation and releasing of Imatinib Mesylate. J Porous Mater 28, 641–649 (2021). https://doi.org/10.1007/s10934-020-01027-3

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