Abstract
The new composite chiral stationary phase for high-performance liquid chromatography was prepared and characterized. Poly(styrene-divinylbenzene) microspherical particles with diameter of 3.3 micron were used as a matrix and coated with layer of 10 nm gold nanoparticles. Immobilized gold nanoparticles increased specific surface area of adsorbent and simplify covalent attachment of sulfur-containing compounds. In this work l-lysine conjugate with lipoic acid was synthesized, characterized and used for modification of gold nanoparticles. The prepared chiral selector was immobilized by the reaction of sulfur-containing groups from lipoic acid residue with gold surface of nanoparticles with formation of self-assembled monolayer. The prepared chiral stationary phase was characterized by nitrogen adsorption at low temperatures, diffuse reflection spectroscopy, scanning electron microscopy. The chromatographic retention of beta-blockers and profens was studied under conditions of reversed-phase HPLC. The possibility of enantiomers separation was demonstrated for flurbiprofen and ketoprofen racemates using 100 × 4.6 mm ID chromatographic column.
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Data Availability
The data that support the findings of this study are available from the corresponding author Prosuntsova D.S., upon reasonable request.
Code availability
Not applicable as all data can be requested from the corresponding author Prosuntsova D.S., upon reasonable request.
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Acknowledgements
This study was funded by the Russian Foundation for Fundamental Research (Grant No. 20-33-90177).
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This study was funded by the Russian Foundation for Fundamental Research (Grant No. 20-33-90177).
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Conceptualization: IAA, PNN; methodology: EKB, AYP, DSP; formal analysis and Investigation: DSP, AYP; writing—original draft preparation: DSP, AYP; writing—review & editing: PNN, EKB, IAA; funding acquisition: IAA; supervision: IAA. All authors read and approved the final manuscript.
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Prosuntsova, D.S., Plodukhin, A.Y., Ananieva, I.A. et al. New composite stationary phase for chiral high-performance liquid chromatography. J Porous Mater 28, 407–414 (2021). https://doi.org/10.1007/s10934-020-00985-y
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DOI: https://doi.org/10.1007/s10934-020-00985-y