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Fabrication of Hydrogel-Nano Silver Based on Aloe vera/Carboxymethyl Cellulose/Tannic Acid for Antibacterial and pH-Responsive Applications

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Abstract

Hydrogels integrated with a smart function pH-responsive play an important role in wound healing. In this study, the effect of tannic acid (TA) on the properties of nanocomposite hydrogels based on carboxymethyl cellulose (CMC), Aloe vera and green synthesized silver nanoparticles (CMC/Aloe vera/AgNPs-TA) were investigated. The minimum inhibitory concentration against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was observed in nanocomposite hydrogels containing AgNPs and 0.5% TA (AgNPs-TA-0.5). Furthermore, the highest storage modulus at 4555.3 kPa was also observed in AgNPs-TA-0.5. The obtained nanocomposite hydrogel is pH-responsive, and the release of TA could be tuned by adjusting the pH. The cytotoxicity studies with human fibroblast cells revealed that the hydrogel is non-toxic and hence suitable for biomedical uses such as multifunctional wound dressing.

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Acknowledgements

This work was supported by the Royal Golden Jubilee Ph.D. scholarship of the Thailand Research Fund (Grant No. PHD/0220/2560) and Research and Graduate Studies, Khon Kaen University, Thailand. Natural Sciences and Engineering Research Council of Canada (NSERC) is acknowledged for partial funding of this work.

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Authors and Affiliations

  1. Department of Chemical Engineering, Faculty of Engineering, Sustainable Infrastructure Research and Development Center, Khon Kaen University, Khon Kaen, 40002, Thailand

    Artjima Ounkaew, Chaloton Jarensungnen, Nattakan Jaroenthai & Pornnapa Kasemsiri

  2. Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Thidarut Boonmars & Atchara Artchayasawat

  3. Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, T6G 2R3, Canada

    Ravin Narain

  4. Department of Civil Engineering, Faculty of Engineering, Sustainable Infrastructure Research and Development Center, Khon Kaen University, Khon Kaen, 40002, Thailand

    Prinya Chindaprasirt

  5. Academy of Science, Royal Society of Thailand, Dusit, Bangkok, 10300, Thailand

    Prinya Chindaprasirt

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Ounkaew, A., Jarensungnen, C., Jaroenthai, N. et al. Fabrication of Hydrogel-Nano Silver Based on Aloe vera/Carboxymethyl Cellulose/Tannic Acid for Antibacterial and pH-Responsive Applications. J Polym Environ 31, 50–63 (2023). https://doi.org/10.1007/s10924-022-02611-1

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