Abstract
In this work, pH-sensitive hydrogel beads based on fish scale collagen and carrageenan were used as a novel allopurinol drug loading system to improve the bioavailability of allopurinol, which is used to treat gout and high levels of uric acid in the human body. The effectiveness of the carrageenan/collagen/allopurinol hydrogel beads in improving the physical properties of allopurinol and the ability for drug release control in different simulated body fluids were evaluated by infrared (IR) spectroscopy, field emission scanning electron microscopy (FESEM), differential scanning calorimetry (DSC), dynamic light scattering (DLS) and Ultraviolet–Vis (UV–Vis) spectroscopy. In addition, the ability of hydrogen bond formation between allopurinol, carrageenan and collagen was calculated theoretically based on the B3LYP/6-31+g(d)//B3LYP/6-311++g(d,p) level of theory. Both the theoretical and experimental results proved that the hydrogen bonds of the functional groups in allopurinol with the functional groups in carrageenan and fish scale collagen contributed to the enhancement of drug release control as well as to the bioavailability of allopurinol loaded into the carrageenan/collagen hydrogel beads. The dissolution of carrageenan/collagen/allopurinol hydrogel beads in different simulated body fluids increased by 1.6 to 6.7 times compared to that of crystalline allopurinol.
Graphic Abstract
Similar content being viewed by others
References
Pathan IB, Munde SJ, Shelke S, Ambekar W, Mallikarjuna SC (2019) Int J Polym Mater Polym Biomater 68:165
Iswariya S, Velswamy P, Uma TS (2018) J Polym Environ 26:2086
Yang C, Wu H, Wang J (2019) Mater Technol 34:534
Shalaby M, Agwa M, Saeed H, Khedr SM, Morsy O, El-Demellawy MA (2020) J Polym Environ 28:166
Bo A, Yu-Shan L, Barbara B (2016) Adv Drug Deliv Rev 97:69
Perez PV, Jiménez RM, Romero A, Guerrero A (2019) Int J Bio Macromol 139:262
Lin Q, Huo Q, Qin Y, Zhao Z, Tao F (2016) Bioengineered 8:55
Naghshineh N, Tahvildari K, Nozari M (2019) J Polym Environ 27:2819
Aishwarya S, Mahalakshmi S, Sehgal PK (2008) J Microencapsul 25:298
Prabu P, Dharmaraj N, Santosh A, Lee BM, Vijaya R, Kim HY (2006) J Biomed Mater Res 79A:153
Schlapp M, Friess W (2003) J Pharm Sci 92:2145
Fitzgerald KA, Guo J, Tierney EG, Curtin CM, Malhotra M, Darcy R, O'Brien FJ, O'Driscoll CM (2015) Biomaterials 66:53
Jun KW, Kim PY, Yong YC, Timothy TY, Nguan ST, Véronique A, Cleo C (2017) Acta Biomater 63:246
Tacharodi D, Panduranga RK (1996) Int J Pharm 134:239
Albu MG, Ghica MV, Leca M, Popa L, Borlescu C, Cremenescu E, Trandafir V (2010) Mol Cryst Liq Cryst 523:97
Naresh K, Shahin SA, Vikash KD, Utpal B (2010) J Protein Proteom 1:9
Ruszczak Z, Friess W (2003) Adv Drug Deliv Rev 55:1679
Park SN, Kim JK, Suh H (2004) Biomaterials 25:3689
Cascone MG, Di Silvio L, Sim B, Downes S (1994) J Mater Sci Mater Med 5:770
James M, Alyssa P (2017) Acta Biomater 49:78
Chie K, Tomoyuki S, Kenji W, Mikako O, Ayano F, Eiko N, Atsushi H, Kenji K, Takashi I, Yasuhiro M (2013) Acta Biomater 9:5673
Tihan GT, Ungureanu C, Barbaresso RC, Zgârian RG, Rău I, Meghea A, Albu MG, Ghica MV (2015) C R Chim 18:986
Yunpeng L, Yan Q, Ruyu B, Xin Z, Limin Y, Jun L (2019) Int J Bio Macromol 134:993
Chakraborty S (2017) J Carbohydr Chem 36:1
Gholam RM, Hossein E, Fatemeh S (2015) Carbohydr Polym 128:112
Jina SV, Nisha C, Nishter NF (2014) Colloid Surf B 113:346
Malairaj S, Ramar T, Mani G, Raju V, Sengottuvelan B, Subramani N, Palani G, Balarama M, Ramasamy R (2017) Carbohydr Polym 160:184
Jie L, Xiaoqin Y, Enbo X, Zhengzong W, Xueming X, Zhengyu J, Aiquan J (2015) J Carbohydr Polym 131:98
Gholam RM, Amirabbas M, Moslem S, Mohammad S (2017) Int J Bio Macromol 97:209–217
Santamaría VJ, Rozo TG, Barreto CB (2019) J Polym Environ 27:774–783
Jagdale SC, Musale V, Kucheka BS, Chabukswar AR (2011) Braz J Pharm Sci 47:3
Khouloud AA, Wasfi MO, Naji MN (2001) AAPS Pharm Sci Tech 2(1):27–33
Chinh NT, Manh VQ, Trung VQ, Lam TD, Huynh MD, Tung NQ, Trinh ND, Hoang T (2019) Nat Prod Commun 14:1–12
Ma S, Chen L, Liu X, Li D, Ye N, Wang L (2012) Int J Green Energy 9(1):13–21
Chun-Yung H, Jen-Min K, Shu-Jing W, Hsing-Tsung T (2016) Food Chem 190:997
Laurent B, Marianne O (2011) Biophys J 101:228
Rhein-Knudsen N, Ale M, Meyer A (2015) Marine Drugs 13:3340
Chinh NT, Trang NTT, Giang NV, Thanh DTM, Hang TTX, Tung NQ, Truyen CQ, Quan PM, Long PQ, Hoang T (2016) J Appl Polym Sci 133:43330
Hoang T, Lam TD, Loc TT, Giang LD, Trang TDM, Trung VQ, Anh NT, Trinh ND, Chinh NT (2019) J Polym Environ 27:2728
Florin AR, Markus B, Peter K, Geoffrey WL, Wolfgang CF (2002) J Pharm Sci 91:964
Gaussian09 Rev. C01, Gaussian, Inc, Wallingford
Silva AM, Ghosh A, Chaudhuri P (2013) J Phys Chem A 117:10274
Hiroko XK, Ayumi K, Colin KK, Jinta O, Shusuke Y, Haruki N, Yu T (2019) J Comput Chem 40:2043
Joshua AP, Dannenberg JJ (2011) J Phys Chem B 115:10560
Boys SF, Bernardi F (1970) Mol Phys 19:553
Acknowledgements
This research was funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.02-2017.326, period of 2018–2021.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflicts of interest
There are no conflicts to declare.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Nguyen, C.T., Vu, M.Q., Phan, T.T. et al. Novel pH-Sensitive Hydrogel Beads Based on Carrageenan and Fish Scale Collagen for Allopurinol Drug Delivery. J Polym Environ 28, 1795–1810 (2020). https://doi.org/10.1007/s10924-020-01727-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10924-020-01727-6