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Effectiveness of Virtual Reality in Anxiety and Pain Management in Children and Adolescents Receiving Cancer Treatment: A Systematic Review and Meta-analysis of Randomized Controlled Trials

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Abstract

Trials.

The study aimed to investigate the effect of virtual reality interventions on relieving pain and anxiety in children and adolescents receiving cancer treatment. A search that involved Cochrane Library (comprising Cochrane Central Register of Controlled Trials (CENTRAL)), PubMed, ProQuest, MEDLINE, Web of Sciences, Science Direct, and Scopus electronic databases covering the records from January 1, 2000 up to May, 2023 was conducted to determine randomized controlled trials that could be included in our study. The results of the search were limited to “anxiety and pain, adolescents, children, virtual reality, cancer.” Of the 160 articles that were reached during the search, seven were found eligible based on inclusion criteria. Hedges’ g effect size was calculated for each article. Random effects model was used to test effect sizes and moderator variables. The registration number of this meta-analysis on PROSPERO is CRD42022304737. The outcomes were pain and anxiety. Compared with standard care, virtual reality had a medium and significant effect on anxiety (g = 0.60, 95% CI: [− 1.05 − 0.15]) and pain (g = − 0.667, 95% CI: [− 1.08− -0.24]). In addition, age has been identified as an important moderator in the use of virtual reality in pain management. This meta-analysis shows that virtual reality applications are effective interventions for reducing pain and anxiety in the field of pediatric oncology. However, it is necessary to carry out randomized controlled trials that have large samples for evidence-based virtual reality applications in pediatric oncology.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable reques.

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Authors and Affiliations

  1. Gazi University, Nursing Faculty, Pediatric Nursing Department, Ankara, Turkey

    Cigdem Sari Ozturk & Ebru Kilicarslan Toruner

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Contributions

Conceptualization, C.S.O and E.K.T; methodology, C.S.O and E.K.T; software and formal analysis, C.S.O; writing—original draft preparation, C.S.O and E.K.T; writing, review and editing, C.S.O; visualization, C.S.O and E.K.T; supervision, C.S.O and E.K.T ; All authors have read and agreed to the published version of the manuscript.

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Correspondence to Cigdem Sari Ozturk.

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Ozturk, C.S., Toruner, E.K. Effectiveness of Virtual Reality in Anxiety and Pain Management in Children and Adolescents Receiving Cancer Treatment: A Systematic Review and Meta-analysis of Randomized Controlled Trials. J Med Syst 47, 103 (2023). https://doi.org/10.1007/s10916-023-01995-4

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