Introduction

Physiological signals contain abundant personalized information. Studies have shown that vital signs can help to detect early deterioration in a general ward. In current medical practice, vital signs of patients at general wards are often measured at an interval of more than 8 h [1, 2], only 2–4 times per day. According to some studies, 75% of the preventable adverse events occurred in patients who were not monitored outside the ICU, and 84% of them showed signs of deterioration in the first eight hours of an adverse event such as cardiopulmonary arrest [3]. As a result of non-continuous monitoring of physiological signals and low frequency of vital sign collection, many detailed early signs of deterioration may be missed, especially at night [4]. However, the medical resources of the general ward are difficult to achieve full-time and light-weight monitoring, which is a risk for patients [5, 6].

With the development of wearable technology, wearable devices have the capability to monitor different physiological signals and are more suited to be deployed at general wards because of their advantages of low-cost, remote and real-time monitoring [7,8,9,10]. In addition, artificial intelligence (AI) technology has become a hot-spot in recent years. Wearable technologies based on AI have led to numerous novel functions so that many research findings of medicine based on machine learning have become available. The changes in wearable devices brought about by AI technology are summarized as follows: First, the methods of monitoring and health management have been diversified. Many wearable devices gather physiological signals via ambient wireless technologies, such as 3G/4G/5G, Bluetooth, or Wi-Fi, and users can see the results and receive advice on a smartphone wherever they are [11,12,13,14]. These functions might help make users capable of basic self-management. Second, medical decision assistance can be provided with the diagnosis and prediction algorithms. The development of different algorithms and models makes some applications of diagnosis and prediction more reliable and robust using wearable devices [15,16,17,18]. Third, the effectiveness of treatment and rehabilitation can be assessed. Some patients need to have their physiological signals monitored for a long time after interventions, or have their daily state monitored in case of accidents.

Even though there are already different kinds of wearable devices and featured applications, most of the applications are still home-grade. Things may become different when they are related to clinical-grade practice, which demands better accuracy and stability. In a narrow sense, medical-grade devices can be defined as devices that be approved by the Food and Drug Administration (FDA). However, some researchers have pointed out that many wearable devices and their functions lack sufficient validation in terms of clinical accuracy and usability [19]. Furthermore, our opinion is that a medical-grade wearable device should be validated in realistic clinical environments against traditional accepted medical grade equipment in order to prove its accuracy and feasibility. A series of previous validation studies have shown that some well-known wearable devices, such as SensiumVitals and HealthPatch, can measure physiological signals accurately when patients are in bed [4]. However, patients at general wards are not always in a relatively static state, thus throwing doubt on the accuracy of the signals measured by wearable devices. On the other hand, the high-value information hidden in physiological signals remains to be discovered. Although researchers have developed a large number of methods such as heart rate variability (HRV) analysis [20, 21]/multiscale entropy (MSE) [22]/Poincare plot [23, 24] to mine hidden information in the signals, the analysis and utilization of time-series physiological signals remain in its infancy. Rather than providing a bunch of data and increasing the burden of clinicians, researchers need to process what the wearable devices measure and show more further analysis results or conclusions based on evidence. Moreover, Dinh-Le et al. [9] suggested that time-series physiological signals collected by wearable devices have the potential to be combined with electronic health records (EHRs) for analysis. It is also a reminder that the analysis of physiological signals separately may be difficult and the conclusion is not reliable, so integration with EHRs may be the key to finding a way out of the dilemma facing physiological signal analysis. Demographics, lab tests, and anamnesis in EHRs can increase the dimension of information significantly and help us make better use of physiological signals measured by wearable devices.

In this paper, we presented a medical-grade wireless monitoring system that was intended to facilitate the adoption of wearable technologies in the healthcare system, which includes a multi-sensor wearable device, and a set of software and related applications by leveraging machine learning algorithms. On the basis of the system, we explored a set of continuous physiological signal acquisition, storage, analysis, and EHR combination process. The system has been deployed in the general wards in the Hyperbaric Oxygen (HBO) Department and the Respiratory Medicine Department at Chinese PLA General Hospital (PLAGH) since April 2018 and has been collecting data from patient volunteers. To our knowledge, this system is one of the earliest attempts to implement the physiological signal monitoring system in the clinic in China.

Methods

System architecture

Figure 1 is the block diagram of the system architecture. The left block exhibits the patient side of the system, which is always at general wards. The system utilizes wearable devices to obtain patients’ vital physiological signals and transmit the data to servers via Wi-Fi. The middle block shows the servers that we include in our system. The server for data is used for storage while the algorithm server can analyze the signals online based on machine learning algorithms, and we can make full use of the physiological signals in combination with the EHR information in the existing Hospital Information System (HIS) of the hospital. The right block is the user side of our system. There are many AI-based functions displayed on different terminals, including the central monitoring station, workstation for doctors/nurses, and PAD. Clinicians use their own account and password to log into the system. Information is only available to pre-registered users.

Fig. 1
figure 1

Block diagram of the system architecture

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Wearable sensors

The key component of our system is the multi-sensor smart vest, SensEcho [25, 26], which has received clearance from the China FDA (Standard Number: YY 0885–2013 and GB 9706.1–2007). Sensors embedded in the vest provide ECG, respiratory and triaxial acceleration monitoring while the vest enables communication with other third-party wearable devices via the Bluetooth protocol. As a result, information about blood pressure, temperature, SpO2 can also be obtained. The vest is able to store data in the 2-GB local flash memory and/or to transmit the data to the server through Wi-Fi. Its battery supports continuous monitoring for at least 24 h. Data generated by SensEcho can be saved online and offline. SensEcho transmits the data to servers via Wi-Fi in real-time and can store data locally in the equipment before exporting it manually. To protect patient privacy, we use a private encrypted transport protocol. The data transmission between different devices/databases is realized on the intranet of the departments, which means data leakage is unlikely. We use an encryption method to save the local files and named as the ‘.CHE’ file format.

ECG signal

The vest provides a single-lead ECG signal at a 200 Hz sample rate with three fabric electrode patches embedded in the vest so that the patients only need to wear the vest that will collect the ECG signal continuously.

Respiratory signals

Respiratory Inductive Plethysmography (RIP) is the core technology we used to obtain the chest & abdominal respiratory signals, which are sampled at 25 Hz. The vest measures chest and abdomen respiratory movement, and the output is a two-channel respiratory waveform.

Triaxial acceleration signals

The signals are sampled at 25 Hz and the ultra-low-power sensors (ADXL345) are embedded in the vest also. Three channels of signals were measured, which stand for the movement of the patients in different directions. We can work out the posture or activity level of the patients according to these signals.

Blood pressure, temperature, SpO2 signals

These signals are obtained by third-party wearable devices like wrist oximeter or wearable blood pressure monitors. This information is alternative. For example, patients are always asked to wear a wrist oximeter at night to measure SpO2 during sleep for the sake of sleep monitoring.

Data storage

The physiological signals measured by wearable devices at a high sample rate pose a challenge to current data storage methods in a hospital, which means a new type of “Big Data”. As our system is designed and implemented in a data integration approach, it is capable of dealing with heterogeneous clinical data as well as operational data. Heterogeneous data refers to data integration by various data types. In our system, the major heterogeneous data types are: 1) the time-series physiological signals and vital signs captured by wearable devices; 2) the structured EHRs generated from daily clinical practice, such as the patient’s personal information, admission records, and laboratory tests; 3) the unstructured clinical records, such as the medical images report and discharge summary.

We thus adopted a mixed database structure design, which has three different logical databases co-existing in the system, tackling the three corresponding data types aforementioned. The information across different databases is linked by ‘patientID’, ‘admissionID’ and ‘deviceID’, to guarantee the integrity of data. These three databases are elaborated on as follows.

Time-series database for physiological signals

In our system, we leveraged InfluxDB (v1.7) as our time-series database. InfluxDB exploits the Time Structured Merge Tree (TSM Tree) data structure, and demonstrates superior performance in writing, querying data compression as well as scalability and usability.

Relational database for structured EHRs

We adopted MariaDB as our relational database solution for the structured EHR data. The EHRs are synchronized from the HIS through RESTful application programming interface (RESTful API). The operational data, such as application’s operation records, is stored in the customized schema as well.

Document-oriented database for unstructured data

For the data that is not described in a relational manner, the document-oriented database, MongoDB, is used. Aside from the unstructured clinical notes, the JavaScript Object Notation formatted computation results returned from the customized applications or interfaces are stored into MongoDB as well.

Functions and applications

Functions and applications of the system are data-driven, which reflect our efforts to make the diagnosis and treatment processes more scientific. The workflow of data analysis is shown in Fig. 2. As is designed, different physiological signals, such as ECG and respiratory waves, are measured by wearable devices. In this process, preliminary analysis precedes the retrieval of information, which is relatively primitive results that can reflect much valuable information. Furthermore, features can be extracted to build some machine learning models. Limited by the analysis capabilities of current complex time-series data and sophistication of machine learning, the purpose of modeling at present is to provide more valuable information in order to support decision-making. To improve the performance of models, such EHR information as lab test results and treatment should be included in the models. Reports can be generated based on all the information available from the wearable devices. Each step in the data process can be expanded according to actually needed.

Fig. 2
figure 2

The workflow of time-series physiological data analysis

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Real-time monitoring

The system can continuously monitor the physiological signals such as heart rate (HR), respiratory rate (RR), SpO2, blood pressure, posture/activities. Once a patient is admitted to the department, a nurse will scan the Quick Response (QR) code on the device and link it with the patient’s information. Monitoring will begin after the nurse helps him/her put the vest on. As is shown in Fig. 3a, the real-time monitored HR, RR, SpO2 and blood pressure are shown on the screen. Physiological parameters out of normal range will be displayed as red to raise the attention of doctors. Anomalies such as falls and arrhythmias can be detected in real-time and displayed on a warning list. As is shown in Fig. 3b, this page displays some more specific time-series information of patients. Postures, activity states, early warning score (EWS) can be calculated and displayed on the screen in real-time.

Fig. 3
figure 3

The real-time monitoring function of the system. a Administration & monitoring page b Real-time monitoring page

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AI-based application

To facilitate machine learning technology in the system, we designed several featured AI-based applications such as sleep stage classification, sleep apnea detection, abnormal ECG signal recognition and classification and atrial fibrillation detection. These algorithms can deeply mine the hidden information in physiological signals for clinical diagnosis and treatment. We take the sleep stage classification algorithm as an example to elaborate on the data utilization when it comes to AI-based applications.

Sleep stage classification algorithm

Inspired by previous studies [27, 28], we trained a deep learning model on the third party dataset then finetuned the model on our in-house dataset. We set a non-overlapping observation window for 30 s to extract the features, which were fed into 16-unit Bi-directional Long Short-Term Memory (BLSTM) layers and one fully-connected layer with 4-unit outputs corresponds to the four sleep stage classes (wake, light sleep, deep sleep and rapid eye movement (REM)). The structure of the BLSTM is shown in Fig. 4. An open-access sleep database, sleep heart health study (SHHS) [29], was used for model training because the volume of the in-house dataset is not big enough for the establishment of a model (about 30 labeled cases right now). The SHHS database consists of the PSG monitoring of 6600 patients in the U.S. The six-class sleep stage data for each subject manually determined by clinical experts in the database was converted into four-class (wake, light sleep (Non-rapid eye movement (NREM)-1 and NREM-2), deep sleep (NREM-3 and NREM-4), REM). Due to the limitation of the data information dimension of the training set, we only used the R-R interval and respiratory signal to extract features, the EHR information such as demographics, lab tests, drug, and anamnesis information has not been included as well. We finally extracted 152 features from R-R intervals and respiratory signals to build and train the model [30,29,32]. Five-fold cross-validation was performed to test the model in the training phase, and the best model was selected to further validate the performance and we finetuned the model on the continuously collected and collated in-house dataset.

Fig. 4
figure 4

BLSTM based sleep stage classification algorithm framework

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Daily reports

Based on the signal process technology and machine learning algorithms implemented in the algorithm server, we can generate a series of reports to doctors, nurses and patients daily. The types and functions of the reports are summarized as below.

Sleep quality and sleep disorder screening report

Sleep quality is essential to human being’s health, sleep disorder, sleep structure and sleep apnea are highly correlated with cardiovascular health [33, 34]. Total sleep time, lasting time of the four sleep stage classes, frequency and type of sleep apneas and some other information are summarized in this report, which reflects the sleep quality of the patient.

HRV analysis report

It is widely accepted that heart rate fluctuates all the time, while HRV measures the variation in beat-to-beat intervals in heart rate and is considered important for cardiac health [35]. HRV variables can be divided into three broad categories: time-domain variables, frequency domain variables and non-linear variables [36]. The HRV variables, as well as Poincare plot and detrended fluctuation analysis are summarized in this report.

Daily activity/posture analysis report

Total activity time, total bedtime and energy expenditure are summarized in this report. The HR, RR and energy expenditure at each time point throughout the day can be seen in the report also. Doctors can leave recommendations below based on the report.

Other reports

There are some other daily analysis reports derived from the continuous monitored physiological data (usually 24 h), such as CPC analysis and breathing pattern analysis, mental stress analysis, multiple-scale analysis on heart rate and breathing rate, which are still under clinical validation and will put into clinical use when they are qualified for diagnosis and treatment purpose.

As is shown in Fig. 5, users (clinicians and nurses) can generate a report by using data in local files (also can generate reports online). Some of the reports are still under validation. The types of reports and capabilities of this function are expanding with the feedback from the clinicians and implementation of new algorithms.

Fig. 5
figure 5

Report generation page (using local CHE files)

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Validation experiment

Several system performance validation experiments are underway, including the physiological signal measurement veracity and algorithm performance. In this paper, we conducted a heart rate veracity validation study, in which we compared the system with ECG Holter.

Heart rate veracity validation

Patients admitted to the HBO Department in PLAGH and subjected to 24-h continuous ECG check were informed about the objectives and risks of the experiment and inquired about their willingness to participate in the study. Volunteers were monitored on the first day of admission both by SensEcho and ECG Holter (BI6812, Biomedical Instruments Company, China. It’s a type of Holter commonly used in clinical practice in PLAGH.) and they were allowed to move freely. The study was approved by the ethics committee of PLAGH.

The raw data transmitted by SensEcho contained the measurements and their timestamps while the raw ECG data gathered by ECG Holter was retrieved in TXT format. We scanned the ECG data of the two devices with the same algorithm in order to mark the R wave positions. Afterward, the HR was calculated according to R-R intervals. In order to reduce the impact of outliers in the signals, we set one rule that was applicable to both devices: We scanned the signal according to the 3δ principle, the time window we set was 60 s, we calculated the mean (\( \overline{\mathrm{x}} \)) and standard deviation (δ) in the time window and checking if the HR value of the middle point was within\( \overline{\mathrm{x}}\pm 3\delta \), then we considered the points beyond the threshold as outliers as well. Finally, we set all of the outlier points in signals to null (NaN) which were not included in the analysis. HR data was then resampled to once per minute before subsequent analysis. We defined HR < 50 beats per minute (bpm) as bradycardia and HR > 100 bpm as tachycardia according to the reference standard [37,36,39].

To align the timeline, the offset was calculated by using the best fit of a cross-correlation of the heart rate between the two signals before the spare data was cut to make sure the experiment started and ended at the same time point.

The series of observation pairs of HR measurements derived from the SensEcho and ECG Holter were compared using the Bland-Altman Method [40]. This method compared the measurements from two devices by evaluating the relationship between the HR differences and the average at every second of the records [41].

Results

HR veracity validation result

Twenty-seven patients were enrolled in this study between March 2018 and August 2019. Data was lost for five patients due to technical issues. In addition, we expected the monitoring to last 24-h or more for each patient. However, the fact was that due to the demand for clinical practice, some of the monitoring had to be suspended ahead of time. As a result, the monitoring data obtained from the 22 patients lasted from 591 min to 1434 min. The median (Q1 - Q3) monitoring time was 1411 (1338–1418) minutes. The basic information of the patients is shown in Table 1. In this table, similar characteristics of the patients in the HBO Department could be identified, who were mostly overweight, middle-aged and elderly, and afflicted with senile diseases.

Table 1 Basic information of patient volunteers
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Examples of patient measurements

Figure 6a shows 10-min ECG and HR signals SensEcho and the Holter measured from patient NO.01, who was a 62-year-old female patient with extensive cardiac and vascular comorbidities like hypertension, hyperlipemia, arrhythmia. The red dots in the subplot 1&2 of Fig. 6a mark the R peaks in the ECG signals. Figure 6b shows the same periods of signals as in Fig. 6a, a respiratory wave is measured from the chest by SensEcho. From the respiratory wave and triaxial acceleration signals, we can find that the patient was quiet and the increase of HR was not caused by movement. Afterward, the increase of HR was recognized as tachycardia by a clinical expert that lasted about 4-min and the following two spines in Fig. 6b were two premature beats. The time tachycardia occurred was about 5:30 am and such clinically abnormal events are often ignored by clinicians or patients. The Fig. 6c shows the entire HR signals of this patient monitored by SensEcho and Holter respectively, which consist of 80,513 s of recording. It can be seen from Fig. 6 that the two systems have good consistency in terms of ECG recording and heart rate calculation.

Fig. 6
figure 6

An example of signals monitored by SensEcho and Holter in the validation study. a 10-min scope of signals Holter and SensEcho measured of patient NO.01. b HR, respiration and triaxial acceleration SensEcho measured. c The entire HR signals of this patient SensEcho and Holter monitored

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HR comparison

For analysis, 468.98-h of HR data from 22 patients was available and the measurement pairs were 28,374. The mean bias (Holter minus SensEcho) in HR was 0.04 bpm with a 95% confidence interval (CI) of −7.34 to 7.42 bpm. Figure 7 is a box plot to show the HR measurement distribution of every patient. From Fig. 7, we can find that most of the patient volunteers showed similar performance between the two methods while the difference that may have been caused by the wearable vests that were not the right size rigorously. Figure 8a is the Bland-Altman plot of the whole dataset. The analysis showed that 98.52% of the points were located between Mean ± 1.96SD. From Fig. 8b we can find that the Bland-Altman plot shows great agreement between the two measurement methods, but the SensEcho is more likely to produce measurements that are too high or too low compared to the Holter. However, these measurements are quite unlikely, for there are only very few points located outside Mean ± 1.96SD. We can still consider the HR measurement capacity of SensEcho reliable. In addition, unbalanced measurements may be caused by the difference in hardware passbands between the two devices.

Fig. 7
figure 7

Boxplot of the HR measurement distribution of the two methods for every patient

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Fig. 8
figure 8

Agreement analysis plots of the two methods. a Bland-Altman plot of the HR measured by the two methods. b Deviation of measurements of SensEcho against the ‘golden standard’, Holter

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During the long-term and high-frequency sample rate of the monitoring of the high-risk patients, as we defined before, tachycardia (HR > 100 bpm) was 1.27% and 1.23% while bradycardia (HR < 50 bpm) was 0.49% and 0.54% of all HR measurements for Holter and SensEcho respectively. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated and are shown in Table 2.

Table 2 Diagnostic accuracy for bradycardia, tachycardia (a Positive Predictive Value; b Negative Predictive Value; c F1=2 * (Precision * Recall) / (Precision + Recall))
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The Bland-Altman analysis quantitatively showed that there was great consistency between SensEcho and the ECG Holter at HR measurement. The difference was relatively small and understandable. One major reason for the difference between the two devices was outliers. Although we set filtering methods to detect the outliers and reduce the impact of them, outliers were unavoidable in time series physiological signals. Furthermore, the difference between the two devices may be due to the hardware clock limitations, where 1 s on one device might correspond to 0.98 s from the other device for example [41].

An example of report

By utilization of the raw data measured from patients, processed information from preliminary analysis, AI-based applications and EHR information from HIS, we can generate various reports. Figure 9 shows an example sleep quality and sleep disorder screening report of a patient. Figure 9a shows the trend-charts where we can visually see the sleep stage classification, posture, the onset and duration of apnea/hypopnea and physiological signals of the example patient. Figure 9b shows a summary of the sleep monitoring results, which includes numerical statistics of different indicators. From the example patient, we can find that the patient went to sleep at about 11:30 pm. Time of total sleep and deep sleep was lower than the reference values, the sleep structure of this patient was not very good as well. SpO2 declined several times and lasted for a while and sleep respiratory events occurred during sleep monitoring. The longest sleep apnea lasted for 29.0 s while the total sleep apnea lasted for 7 min and 21 s. 64.7% of sleep respiratory events were classified as obstructive sleep apnea, while 35.3% were classified as hypopnea. The apnea-hypopnea index (AHI) of the patient this night was 2.7, which is lower than the clinical diagnostic criteria of clinical sleep apnea-hypopnea syndrome. Certainly, the information provided by the system is an expansion of the information available to clinicians, which should be confirmed and can be modified by clinicians in case the algorithms are misdiagnosed.

Fig. 9
figure 9

A part of an example sleep quality and sleep disorder screening report. a Example patient’s physiological signal trend-charts throughout the night. b The checkup results of the patient. AHI: Apnea Hypopnea Index

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A case study

In order to further explain the value of the system applied in the clinic, we illustrate a case of a patient monitored by the SensEcho at the general ward of the HBO department, who was 44 years old, male, 180 cm height, 85 kg weight when admitted, and complained of chest pain for 2 years. He was diagnosed with coronary heart disease, myocardial infarction, hyperlipemia and hypertension risk level 3. Figure 10 shows a section of the HR, RR and triaxial acceleration signals for his first night of admission, when the patient experienced a deterioration of his condition. Doctors gave first aid when the system generated alarms at about 9:15 pm. Meanwhile, we found that from 9:15 pm to 9:30 pm, the patient got two episodes of atrial fibrillation. The first one was 10 min ahead of the coming severe atrial fibrillation. A high frequency of premature beats occurred before 9:00 pm also. From the triaxial acceleration signals, we can find that the patient was relatively quiet before the atrial fibrillation occurred and he changed his position before the first atrial fibrillation ended. The second episode of atrial fibrillation was deadly and needed intervention immediately. Fortunately, he survived. It is believed that in this case the detailed information of disease deterioration may be missed in the absence of monitoring by the system.

Fig. 10
figure 10

Vital signals monitored by SensEcho of a patient with atrial fibrillation in HBO department

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Discussion

In this paper, we present a wireless physiological signal monitoring system, which is intended to provide higher dimensional information in order to realize patient health state monitoring and clinical decision support. Potential users include doctors, nurses and patients. For doctors, they receive various daily reports which contain physiological signal monitoring results, preliminary analysis results and AI-based decision support suggestions. For nurses, the system can decrease their workload. Some of the clinical practices are expected to be replaced by the system as well. For patients, the system can provide real-time multi-dimensional physiological signal monitoring, leading to better care and early warning of clinical deterioration. The system has been deployed in realistic clinical practice. Our key contributions are summarized as follows.

  • SensEcho is a medical-grade wireless monitoring system, which provides comprehensive information of patients for clinicians based on signal processing technology and machine learning algorithms.

  • We have deployed this system in a clinical environment and constantly update it according to the clinical feedback. The system is one of the earliest attempts to implement the physiological signal monitoring system in the clinic in China.

  • The system is well integrated with the existing HIS and we provide a practical way to combine the EHRs and physiological signals.

  • We explored a set of time series physiological signal acquisition, storage, and analysis processes, facilitating the follow-up research studies.

Currently, many studies on monitoring systems focus on the early warning of the risk of disease deterioration and have shown that the wearable devices have better performance than EWS, which is a commonly used clinical score [4, 6, 37]. We believe that wearable devices have the potential to provide more valuable information as a clinical aid based on the analysis of physiological signals. There is a wealth of information in the reports we provided, which can help clinicians make better evaluation of patients or quantitatively evaluate the therapeutic effect. Moreover, an important prerequisite for good system operation is the guarantee of good data quality. We designed a set of schemes to ensure data quality and model performance, including training for nurses before implementation of the system, data cleaning standard operating procedure and sufficient validation of the models. To achieve a better capability and usability of the system, we need to develop and explore effective methods to reduce the impact of outliers, improve the measurement accuracy and accumulate more data to improve the model performance.

Despite the application of this system in the HBO and the Respiratory Medicine Department and its featured applications according to the clinical demands, it is believed that there is still a long way to go before the system can be used widely clinically. Furthermore, there are still some limitations to our study. One major limitation is the unfinished validation of several applications in the system. The validation study calls for the cooperation between clinical experts and engineers, which is a kind of cross-disciplinary cooperation that is often difficult but important because we need to match the engineering results with clinical experience. Another limitation of the study is the inadequate use of EHR information, although we tried the combination of EHRs and continuous physiological signals, only a fraction of EHR information has been included, and a great deal of valuable information remains to be integrated.

The future work of our study includes the further validation of the system as well as keeping going on the data mining work of the EHRs and time-series physiological signals. In addition, to our knowledge, there are three extra meaningful and interesting research focuses summarized as follows.

The first research focus is, at the time of writing, the whole world is suffering from the Corona Virus Disease (COVID-19), which has a much stronger infection capacity than the flu. Patients infected with the COVID-19 are more likely to develop symptoms such as fever and respiratory distress, with their SpO2 decline severely. Clinicians are at high risk of infection when having direct contact with patients although they wear protective gear. Experience gained from the pandemic shows that little exposure to the virus can effectively reduce the chance of infection. Clinicians especially nurses, need to measure vital signs of patients several times daily, and this procedure is expected to be replaced by the wireless monitoring system. For patients, the system can monitor multi-dimensional physiological signals that can be used to predict and indicate the deterioration of the new coronavirus pneumonia. In conclusion, we will expand the functions and applications of the system to be more suitable for infectious disease hospitals.

The second research focus is that there are several physiological signal databases for specific use worldwide. However, we have not heard of any comprehensive database that combines the EHR information and physiological signals measured from wearable devices. Up to February 2020, we have already collected more than 1000 cases of data from the realistic clinical environment. We will clean the data and construct a comprehensive database, which will include the physiological signals, information in HIS, manually record tables from the doctors and nurses. It is time-consuming because manually recorded information is always subjective and prone to biases and errors. Data cleaning is a necessary step, and we believe that it is worthwhile and this database will play an important role in follow-up research.

The third research focus is that as individualized and accurate medicine is an important development of modern medicine, personalized information in physiological signals needs to be mined deeply. Continuous monitoring of physiological signals is a new type of ‘Big Data’ for individuals as well, reflecting the health states at different stages. The variation trend between physiological signals of one patient in different periods should be further studied to develop an index that quantitatively evaluates the health level of the patient, which can be used as a solution to individualized and accurate medicine.