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Synthesis of gold Nanoparticles Encapsulated Chitosan/Gelatin Polymers for the Treatment of Several Types of Leukemia

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Abstract

We herein demonstrate the biogenic nano-architechtonics of gold nanoparticles template over chitosan/gelatin mixed hydrogel having excellent reducing ability. The two biopolymers, i.e., chitosan and gelatin also had the capacity to stabilize as-synthesized Au NPs. Physicochemical and structural features of the nanocomposite biomaterial was assessed by several techniques like FT-IR, SEM, TEM, EDX and XRD. TEM study revealed the mean diameter of the spherical shaped Au NPs/CS-Gel material was in the range of 10–15 nm. Thereafter, the Au NPs/CS-Gel bio-composite material was exploited in the study of cytotoxicity and anti-leukemia effects against diverse leukemia cell lines like acute myeloid leukemia (32D-FLT3-ITD and Human HL-60/vcr), acute lymphoblastic leukemia (MOLT-3 and TALL-104), and acute T cell leukemia (Jurkat, Clone E6-1 and J.RT3-T3.5) in situ. Interestingly, the nano-drug could resist significantly against those cell lines in a time and concentration-dependent manner, assessed by MTT method. The corresponding IC50 values of the bio-composite were 341, 500, 417, 407, 389, and 500 µg/mL respectively against the cell lines.

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References

  1. N. Li, G. Li, R. Li, B. Karmakar, A.F. El-kott, M.Z. Bani-Fwaz, S. Negm, K. Morsy, Synthesis of au NPs/Quince nanoparticles mediated by Quince extract for the treatment of human cervical cancer: introducing a novel chemotherapeutic supplement. Mater. Express. 12, 1465–1473 (2022)

    Article  CAS  Google Scholar 

  2. Y. Cai, B. Karmakar, A.O. Babalghith, G.E. Batiha, H.S. Alsalem, A.F. El-kott, A.A. Shati, M.Y. Alfaifi, Elbehairi, S E I. decorated au NPs on lignin coated magnetic nanoparticles: investigation of its catalytic application in the reduction of aromatic nitro compounds and its performance against human lung cancer. Int. J. Biol. Macromol. 223, 1067–1082 (2022)

    Article  CAS  PubMed  Google Scholar 

  3. M. Shah, S. Faisal, S. Gul, S. Khan, S. Abdullah, S. Ali Shah, W. Ali Shah, Monotheca buxifolia Driven Synthesis of Zinc Oxide Nano Material Its Characterization and Biomedical Applications, R. Shah, S.A. Shah, S. Shah, S. Faisal, F. Ullah,. Micromachines 2022, 13(5), 668; (b) Zafar, S.; Faisal, S.; Jan, H.; Ullah, R.; Rizwan, M.; Abdullah; Alotaibi, A.; Bibi, M.; Ur Rashid, A.; Khattak, A. Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential. Micromachines. 2022, 13(8), 1259; (c) Faisal, S.; Khan, S.; Abdullah; Zafar, S.; Rizwan, M.; Ali, M.; Ullah, R.; M. Albadrani, M.; R. H. Mohamed, H.; Akbar, F. Fagonia cretica-Mediated Synthesis of Manganese Oxide (MnO2) Nanomaterials Their Characterization and Evaluation of Their Bio-Catalytic and Enzyme Inhibition Potential for Maintaining Flavor and Texture in Apples. Catalysts. 2022, 12(5), 558; (d) Abdullah; Hussain, T.; Faisal, S.; Rizwan, M.; Saira, Zaman N.; Iqbal, M.; Iqbal, A.; Ali, Z. Green synthesis and characterization of copper and nickel hybrid nanomaterials: Investigation of their biological and photocatalytic potential for the removal of organic crystal violet dye. Journal of Saudi Chemical Society. 2022. 26, 101486; (e) Shah, R., Shah, S.A., Shah, S., Faisal, S., Ullah, F. Green Synthesis and Antibacterial Activity of Gold Nanoparticles of Digera muricata Indian J Pharm Sci 2020;82(2):374–378; (f) Ullah, R.; Shah, S.; Muhammad, Z.; Ullah. R.; Hussain, T.; Rizwan, M.; Saira; Zaman, N.; Iqbal, M.; Iqbal, A.; Ali, Z. Zingiber officinale driven bioproduction of ZnO nanoparticles and their anti-inflammatory, anti-diabetic, anti-Alzheimer, anti-oxidant, and anti-microbial applications. Inorganic Chemistry Communications. 2022, 140, 109274; (g) Shah, S.; Abdullah; Jan, H.; Ali Shah, S.; Shah, S.; Rizwan, M.; Zaman, N.; Hussain, Z.; Nazir Uddin, M.; Bibi, N.; Khattak, A.; Khan, W.; Iqbal, A.; Idrees, M.; Masood, R. Bio-Catalytic Activity of Novel Mentha arvensis Intervened Biocompatible Magnesium Oxide Nanomaterials. Catalysts. 2021, 11(7), 780; (h) Ullah, R.; Shah, S.; Muhammad, Z.; Ali Shah, S.; Faisal, S.; Khattak, Tauheed, U.; ul Haq, T.; Taj Akbar, M. In vitro and in vivo applications of Euphorbia wallichii shoot extract-mediated gold nanospheres. Green Processing and Synthesis. 2021, 10, 101–111; (i) Faisal, S.;Abdullah; Rizwan, M.; Ullah, R.; Alotaibi, A.; Khattak,A.; Bibi, N.; Idrees, M. Paraclostridium benzoelyticum Bacterium-Mediated Zinc Oxide Nanoparticles and Their In Vivo Multiple Biological Applications. Oxidative Medicine and Cellular Longevity. 2022, 2022, 1–15; (j) Shah, S.; Ali Shah, S.; Faisal, S.; Khan, A.; Ullah, R.; Ali, N.; Bilal, M. Engineering novel gold nanoparticles using Sageretia thea leaf extract and evaluation of their biological activities. Journal of Nanostructure in Chemistry. 2022, 12, 129–140; (k) Faisal, S.; Jan, H.; Abdullah; Alam, I.; Rizwan, M.; Hussain, Z.; Sultana, K.; Ali, Z.; Uddin. M. N. In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles. ACS Omega 2022, 7, 5, 4071–4082; (l) Kainat; Aslam Khan, M.; Ali, F.; Faisal, S.; Rizwan, M.; Hussain, M.; Zaman, N.; Afsheen, Z.; Uddin, M.N.; Bibi, N. Exploring the therapeutic potential of Hibiscus rosa sinensis synthesized cobalt oxide (Co3O4-NPs) and magnesium oxide nanoparticles (MgO-NPs). Saudi Journal of Biological Sciences. 2021, 28, 5157–5167; (m) Faisal, S.; Aslam Khan, M.; Jan, H.; Shah, S.A.; Abdullah; Shah, S.; Rizwan, M.; Wajidullah; Akbar, M.T.; Redaina. Edible mushroom (Flammulina velutipes) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications. Nanotechnology. 2021, 32, 065101; (n) Jan, H.; Khan, M.A.; Usman, H.; Shah, M.; Ansir, R.; Faisal, S.; Ullah, N.; Rahman, L. The Aquilegia pubiflora (Himalayan columbine) mediated synthesis of nanoceria for diverse biomedical applications. RSC Adv., 2020,10, 19219–19231; (o) Faisal, S.; Jan, H.; Shah, S.A.; Shah, S.; Khan, A.; Akbar, M. T.; Rizwan, M.; Jan, F.; Wajidullah; Akhtar, N.; Khattak, A.; Syed, S. Green Synthesis of Zinc Oxide (ZnO) Nanoparticles Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications. ACS Omega. 2021, 6, 14, 9709–9722

  4. J. Zheng, B. Karmakar, A.F. El-kott, F.G. Elsaid, A.A. Shati, S. Negm, A.A. Alsayegh, G.E. Batiha Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation, H. Veisi, Z. Ebrahimi, B. Karmakar, T. Tamoradi, T. Ozturk (eds.), Introducing a novel chemotherapeutic drug, Journal of Saudi Chemical Society, 2022, 26 (6), 101543; (b) Veisi H, Ebrahimi Z, Karmakar B, Tamoradi T, Ozturk T. A convenient green protocol for oxidative esterification of arylaldehydes over Pd NPs decorated polyplex encapsulated Fe3O4 microspheres. Int. J. Biol Macromol. 2022;200:132–138

  5. , ed. by M. Hamelian, K. Varmira, B. Karmakar, H. Veisi, Catal. Lett., N. Alikhani, M. Hekmati, B. Karmakar, H. Veisi, Inorg Chem. Commun. 2022;139: 109351; (c) M. Shahriari, M.A.H. Sedigh, M. Shahriari, M. Stenzel, M.M. Zangeneh, A. Zangeneh, B. Mahdavi, M. Asadnia, J. Gholami, B. Karmakar, H. Veisi Inorg. Chem. Commun. 2022;137:109523; (d), S. Hemmati, M.M. Heravi, B. Karmakar, H. Veisi Sci. Rep. 2021;11:12362; (e), S. Hemmati, M.M. Heravi, B. Karmakar, H. Veisi. J Mol. Liq. 2020;319:114302; (f), M. Shahriari, M.A. Sedigh, Y. Mahdavian, S. Mahdigholizad, M. Pirhayati, B. Karmakar, H. Veisi Int. J. Biol. Macromol. 2021;172:55–61; (g) Veisi H, Tamoradi T, Karmakar B, Hemmati S. J. Phys. Chem. Solids.2020;138:109256–109262

  6. Y. Cai, B. Karmakar, H.S. Al-Salem, A.F. El-kott, M.Z. Bani-Fwaz, S. Negm, A.A.A. Oyouni, O. Al-Amer, G.E. Batiha, H. Veisi, T. Tamoradi, B. Karmakar, P. Mohammadi, S. Hemmati (eds.), Oak gum mediated green synthesis of silver nanoparticles under ultrasonic conditions: Characterization and evaluation of its antioxidant and anti-lung cancer effects, Arabian Journal of Chemistry, 2022, 15 (6), 103848; (b) Veisi H, Tamoradi T, Karmakar B, Mohammadi P, Hemmati S. Mater. Sci. Eng. C 2019;104:109919

  7. A. Bakur, Y. Niu, H. Kuang, Q. Chen, Synthesis of gold nanoparticles derived from Mannosylerythritol lipid and evaluation of their bioactivities. AMB Express. 9, 62 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  8. Y. Zhang, X. Cui, F. Shi, Y. Deng, Nano-Gold Catalysis in Fine Chemical synthesis. Chem. Rev. 112, 2467–2505 (2012)

    Article  CAS  PubMed  Google Scholar 

  9. E.O. Mikhailova, Gold nanoparticles: biosynthesis and potential of Biomedical Application. J. Funct. Biomaterials. 12, 70 (2021)

    Article  CAS  Google Scholar 

  10. N. Kulkarni, U. Muddapur, Biosynthesis of Metal Nanoparticles: A Review. J. Nanotechnol. 2014, 2014, 510246

  11. R. Kumar, Anticancer activity of eco-friendly au nanoparticles against lung and Liver Cancer cells. J. Genetic Eng. Biotechnol. 14, 195–202 (2016)

    Article  Google Scholar 

  12. Y. Ju-Nam, J.R. Led, Manufactured, Nanoparticles, An overview of their Chemistry, Inclination, and potential implication. Sci. Total Environ. 400, 396–4141 (2008)

    Article  CAS  PubMed  Google Scholar 

  13. K. Kim, B. Jung, J. Kim, W. Kim, Effects of Embedding Non-Absorbing Nanoparticles in Organic Photovoltaics on Power Conversion Efficiency. Sol. Energy Mater. Sol. Cells. 94, 1835–1839 (2010)

    Article  CAS  Google Scholar 

  14. G. Geoprincy, B.V. Srri, U. Poonguzhali, N.N. Gandhi, S. Ranganathan, A review on Green Synthesis of Ag Nanoparticles. Asian J. Pharm. Clin. Res. 6, 8–12 (2013)

    CAS  Google Scholar 

  15. A. Thirumurugan, G.J. Jiflin, G. Rajagomathi, N.A. Tomy, S. Ramachandran, R. Jaiganesh, Biotechnological synthesis of gold nanoparticles of Azadirachta indica leaf extract. Int. J. Biol. Technol. 1, 75–77 (2010)

    CAS  Google Scholar 

  16. R. Herizchi, E. Abbasi, M. Milani, A. Akbarzadeh, Current methods for synthesis of gold nanoparticles. Artif. Cells Nanomed. Biotechnol. 44, 596–602 (2016)

    Article  CAS  PubMed  Google Scholar 

  17. P. Mohanpuria, N.K. Rana, S.K. Yadav, Biosynthesis of nanoparticles: Technological Concepts and Future Applications. J. Nanopart. Res. 10, 507–517 (2008)

    Article  CAS  Google Scholar 

  18. M. Singh, R. Kalaivani, S. Manikandan, N. Sangeetha, A.K. Kumaraguru Facile Green Synthesis of Variable Metallic Gold Nanoparticle Using Padina gymnospora, S.B. Santhosh, R. Yuvarajan, D. Natarajan Annona muricata leaf extract-mediated silver nanoparticles synthesis and its larvicidal potential against dengue (eds.), a Brown Marine Macroalga. Applied Nanosciences. 2013, 3, 145–151; (b) Santhosh, S.B., Yuvarajan, R., Natarajan, D. Annona muricata leaf extract-mediated silver nanoparticles synthesis and its larvicidal potential against dengue, malaria and filariasis vector. Parasitol Res 2015, 114, 3087–3096

  19. J.L. Gardea-Torresdey, J.G. Parsons, E. Gomez, J. Peralta-Videa, H.E. Troiani, P. Santiago, M.J. Yacaman, Formation and growth of au nanoparticles inside live alfalfa plants. Nano Lett. 2, 397–401 (2002)

    Article  CAS  Google Scholar 

  20. S. Hemmati, A. Rashtiani, M.M. Zangeneh, P. Mohammadi, A. Zangeneh, H. Veisi, Polyhedron, H. Veisi, S. Hemmati, H. Shirvani, H. Veisi Appl. Organomet. Chem.2016;30:387–391; (c), H. Veisi, Z. Joshani, B. Karmakar, T. Tamoradi, M.M. Heravi, J. Gholami Int. J. Biol. Macromol. 2021172:104–113; (d), M. Nodehi, M. Baghayeri, H. Veisi, S. Talanta, L. Mehrazin, M. Hekmati, M. Izadi, H. Veisi. Mat. Chem.Phys. 2018;214:527–532; (f), M. Baghayeri, H. Veisi, S. Farhadi, H. Beitollahi, B. Maleki (eds.), Journal of the Iranian Chemical Society 2018;15: 1015–1022

  21. J. Chen, B. Karmakar, M.A. Salem, A.Y. Alzahrani, M.Z. Bani-Fwaz, M.M. Abdel-Daim, A.F. El-kott, CuO NPs@ Starch as a novel chemotherapeutic drug for the treatment of several types of gastrointestinal system cancers including gastric, pancreatic, and colon cancers. Arab. J. Chem. 15(4), 103681 (2022)

    Article  CAS  Google Scholar 

  22. X. Ou, B. Karmakar, N.S. Awwad, H.A. Ibrahium, H.E.H. Osman, A.F. El-kott, M.M. Abdel-Daim, Au nanoparticles adorned chitosan-modified magnetic nanocomposite: an investigation towards its antioxidant and anti-hepatocarcinoma activity in vitro. Inorg. Chem. Commun. 137, 109221 (2022)

    Article  CAS  Google Scholar 

  23. M. Shahriari, M.A.H. Sedigh, M. Shahriari, M. Stenzel, M.M. Zangeneh, A. Zangeneh, B. Mahdavi, M. Asadnia, J. Gholami, B. Karmakar, H. Veisi, Palladium nanoparticles decorated Chitosan-Pectin modified Kaolin: it’s catalytic activity for Suzuki-Miyaura coupling reaction, reduction of the 4-nitrophenol, and treatment of lung cancer. Inorg. Chem. Commun. 137, 109523 (2022)

    Article  Google Scholar 

  24. S.A. Aromal, D. Philip, Green synthesis of gold nanoparticles using Trigonella foenum-graecum and its size dependent catalytic activity. Spectrochimica Acta Part A 97, 1–5 (2012)

    Article  Google Scholar 

  25. J.S. Kim, E. Kuk, K.N. Yu, K. Jong-Ho, S.J. Park, H.J. Lee, S.H. Kim, Antimicrobial effects of silver nanoparticles. Nanomedicine. 3, 95–101 (2007)

    Article  CAS  PubMed  Google Scholar 

  26. P. Zhao, A. El-kott, A.E. Ahmed, A. Khames, M.A. Zein, Green synthesis of gold nanoparticles (au NPs) using tribulusterrestrisextract: investigation of its catalytic activity in the oxidation of sulfides to sulfoxides and study of its anti-acute leukemia activity. Inorg. Chem. Commun. 131, 108781 (2021)

    Article  CAS  Google Scholar 

  27. L. Lu, Q. Zhao, Z. Wang, F. Ju, Oak gum mediated sustainable synthesis of goldnanoparticles (au NPs): evaluation of its antioxidant and anti-colon cancer effects. J. Exp. Nanosci. 17, 377–388 (2022)

    Article  CAS  Google Scholar 

  28. N.S. Al-Radadi, Biogenic proficient synthesis of (Au-NPs) via aqueous extract of red dragon pulp and seed oil: characterization, antioxidant, cytotoxic properties, anti-diabetic anti-inflammatory, anti-alzheimer and their anti-proliferative potential against cancer cell lines. Saudi J. Biol. Sci. 29, 2836–2855 (2022)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. S. Menon, S. Rajeshkumar, S. Venkat Kumar, A review on biogenic synthesis of gold nanoparticles, characterization, and its applications. Resource-Efficient Technol. 3, 516–527 (2017)

    Article  Google Scholar 

  30. N. Singh, M.K. Das, A. Ansari, D. Mohanta, P. Rajamani, Biogenic nanosized gold particles: Physico-chemical characterization and its anticancer response against breast cancer. Biotechnol. Rep. 30, e00612 (2021)

    Article  CAS  Google Scholar 

  31. , ed. by N. Abbasi, H. Ghaneialvar, R. Moradi, M.M. Zangeneh Zangeneh. A. 2021. Formulation and characterization of a novel cutaneous wound healing ointment by silver nanoparticles containing Citrus lemon leaf: A chemobiological study. Arabian Journal of Chemistry, 14, pp. 103246. (b) M. Abdoli, K. Sadrjavadi, E. Arkan, M.M. Zangeneh, S. Moradi, A. Zangeneh, M. Shahlaei, S. Khaledian 2020.Polyvinyl alcohol/Gum tragacanth/graphene oxide composite nanofiber for antibiotic delivery. Journal of Drug Delivery Science and Technology. 60, pp. 102044. (c) Gholami, M., Abbasi, N., Ghaneialvar, H., Karimi, E., Afzalinia, A., Zangeneh, M. M., Yadollahi, M. 2022. Investigation of biological effects of chitosan magnetic nano-composites hydrogel. Nanotechnology, 33, pp. 495603. (d) Jalalvand, A.R., Zangeneh, M. M., Jalili, F., Soleimani, S., Díaz-Cruz, J.M. 2020. An elegant technology for ultrasensitive impedimetric and voltammetric determination of cholestanol based on a novel molecularly imprinted electrochemical sensor. Chemistry and Physics of Lipids. 229, pp. 104895

  32. D. Ma, D. Gong, T. Han, M. Javadi, H. Mohebi, M. Karimian, N. Abbasi, H. Ghaneialvar, M.M. Zangeneh, A. Zangeneh, M. Shahriari, F. Zhang, J. Sun, Y. Liu, Z. Shi, Y. Mahdavian, Y. Mahdavian, S. Mahdigholizad, P. Irani, M. Karimian, N. Abbasi, H. Ghaneialvar, A. Zangeneh, M.M. Zangeneh, T. Sun, J. Gao, H. Shi, D. Han, M.M. Zangeneh, N. Liu, H. Liu, Y. Guo, X. Liu, H. Zarafshani, M. Mojarab, M.M. Zangeneh, P. Moradipour, F. Bagheri, F. Aghaz (eds.), 165 (2020), pp. 767–775. (b) Shi, Z., Mahdavian, Y., Mahdavian, Y., Mahdigholizad, S., Irani, P., Karimian, M., Abbasi, N., Ghaneialvar, H., Zangeneh, A., Zangeneh, M. M. Arabian Journal of Chemistry, 14 (2022), pp. 103224. (c) Sun, T., Gao, J., Shi, H., Han, D., Zangeneh, M.M., Liu, N., Liu, H., Guo, Y., Liu. X. International Journal of Biological Macromolecules 165 (2020), pp. 787–795. (d) Zarafshani, H., Mojarab, M., Zangeneh, M. M., Moradipour, P., Bagheri, F., Aghaz, F., Arkan, E. IEEE Transactions on NanoBioscience, 21 (2022), pp. 520–528

  33. N. Jain, P. Jain, D. Rajput, U.K. Patil, Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity. Micro Nano Syst. Lett. 9, 5 (2021). https://doi.org/10.1186/s40486-021-00131-6

    Article  Google Scholar 

  34. K.K. Bharadwaj, B. Rabha, S. Pati, T. Sarkar, B.K. Choudhury, A. Barman, D. Bhattacharjya, A. Srivastava, D. Baishya, H.A. Edinur, Green synthesis of gold nanoparticles using plant extracts as Beneficial Prospect for Cancer Theranostics. Molecules. 26, 6389 (2021). https://doi.org/10.3390/molecules26216389

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Y. Chang, C. Zheng, A. Chinnathambi, T.A. Alahmadi, S.A. Alharbi, Cytotoxicity, anti-acute leukemia, and antioxidant properties of gold nanoparticles green-synthesized using Cannabis sativa L leaf aqueous extract. Arab. J. Chem. 14(4), 103060 (2021)

    Article  CAS  Google Scholar 

  36. M. Abdoli, E. Arkan, Z. Shekarbeygi, S. Khaledian, Green synthesis of gold nanoparticles using Centaurea behen leaf aqueous extract and investigating their antioxidant and cytotoxic effects on acute leukemia cancer cell line (THP-1). Inorg. Chem. Commun. 129, 108649 (2021)

    Article  CAS  Google Scholar 

  37. A. Ahmeda, A. Zangeneh, M.M. Zangeneh, Green synthesis and chemical characterization of gold nanoparticle synthesized using Camellia sinensis leaf aqueous extract for the treatment of acute myeloid leukemia in comparison to daunorubicin in a leukemic mouse model. Appl. Organomet. Chem. 34(3), e5290 (2020)

    Article  CAS  Google Scholar 

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Acknowledgements

The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through large groups under grant number RGP2/232/44.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, 046011, China

    Yanmei Ma

  2. Department of Emergency, Children’s Hospital affiliated to Chongqing Medical University, Chongqing, 400010, China

    Fuxiang He

  3. Biology Department, College of Science, King Khalid University, Abha, 61421, Saudi Arabia

    Attalla F. El-kott & Ali S Alshehri

  4. Zoology Department, Faculty of Science, Damanhour University, Damanhour, 22511, Egypt

    Attalla F. El-kott & Ali M. Eldib

  5. Chemistry Department, University College of AlWajh, University of Tabuk, Tabuk, Saudi Arabia

    Mohamed Abdellatif Zein

  6. Chemistry Department, Faculty of Science, Damanhour University, Damanhour, Egypt

    Mohamed Abdellatif Zein

  7. Alrayan Medical Colleges, College of Medicine, Hejrah Street-Madinah, p.o. Box 41411, Almadinah, Saudi Arabia

    Ali M. Eldib

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  1. Yanmei Ma
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Ma, Y., He, F., El-kott, A.F. et al. Synthesis of gold Nanoparticles Encapsulated Chitosan/Gelatin Polymers for the Treatment of Several Types of Leukemia. J Inorg Organomet Polym 34, 100–109 (2024). https://doi.org/10.1007/s10904-023-02751-4

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