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Constructing NaX Nanozeolite Modified Carbon Paste Electrode for Electro-Catalytic Measurement of Gentamicin Sulfate in Pharmaceutical Samples

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Abstract

Gentamicin sulfate (GNS) as an antibiotic drug is highly polar, non-volatile compound and lacks a UV absorbing chromophore and these properties pose an excessive challenge in the analysis of it for many years. Hence, it is urgent to progress a simple, rapid and low price method for quantification of GNS in medical, chemical and biological fields. This paper dedicated on the building of a novel and sensitive sensor for GNS detection that is created on the decoration of Ni(OH)2 onto nanozeolite NaX modified carbon paste electrode (Ni(OH)2–NaX/CPE). Initially, NaX was synthesized and characterized by numerous practices. Field emission scanning electron microscopy (FESEM) method demonstrated the existence of sphere-shaped nanozeolite NaX with diameter under 100 nm. Cyclic voltammetry investigations displayed that Ni(OH)2–NaX/CPE has impressively improved electro-catalytic oxidation of GNS versus Ni(OH)2/CPE because of mesoporous arrangement of nanozeolite NaX. The amounts of electron transfer coefficient, catalytic rate constant and diffusion coefficient of GNS were found to be 0.77, 1.77 × 104 cm3 mol− 1 s− 1 and 7.02 × 10− 6 cm2 s− 1, respectively. Also, the limits of detection and linear dynamic range were obtained to be 0.82 µM and 2.72–119.60 µM by differential pulse voltammetry method, respectively. The fabricated electrodes were effectively used for quantification of GNS in the pharmaceutical trainings with high accuracy and precision.

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Acknowledgements

We are grateful for financial support from the Research Council of Babol Noshirvani University of Technology.

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  1. Department of Chemistry, Faculty of Basic Science, Babol Noshirvani University of Technology, Shariati Ave, 47148-71167, Babol, Iran

    Nafiseh Masihpour & Seyed Karim Hassaninejad-Darzi

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SKH-D conceived of the presented idea. All authors developed the theory and performed the computations and also, verified the analytical methods. SKH-D to investigate and supervised the findings of this work. All experiments were performed by NM that supervised by SKH-D. All authors discussed the results and contributed to the final manuscript. SKH-D wrote the manuscript with support from NM.

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Correspondence to Seyed Karim Hassaninejad-Darzi.

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Masihpour, N., Hassaninejad-Darzi, S.K. Constructing NaX Nanozeolite Modified Carbon Paste Electrode for Electro-Catalytic Measurement of Gentamicin Sulfate in Pharmaceutical Samples. J Inorg Organomet Polym 33, 1317–1330 (2023). https://doi.org/10.1007/s10904-023-02587-y

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