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Preparation of Folic Conjugated Magnetic Silica Mesoporous Nanoparticles and Their Encapsulated 10-HCPT Anticancer Behavior

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Abstract

A novel folate-decorated and magnetic mediated drug delivery system was fabricated by combining folate and magnetic nanoparticles to the surface of silica mesoporous nanoparticles (FMMSNs) via chemical reaction. The 10-hydroxycamptothecin (10-HPCT), an analogue of camptothecin, was sealed in the mesoporous to evaluate the system’s pharmaceutics performance. The diameter of the FMMSMs was about 100 nm and the in vitro release result showed that the applied magnetic field could influence the release process. The result of the inhibition rate of the 10-HPCT loaded FMMSNs to HepG-2 cells revealed that they could be influenced by the applied magnetic field or the folic acid bonded on the surface of the mesoporous nanoparticles.

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The data used to support the findings of this study are all included within this article.

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Acknowledgements

We gratefully acknowledge the support of this research by the by the Key Research Projects of University in Henan province, China [Grant Number 15A350012].

Funding

Funding was provided by Key Research Projects of University in Henan province, China [Grant Number 15A350012].

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Authors and Affiliations

  1. College of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, China

    Bei-bei Hao, Xiu-zhen Deng, Jia-ke Yang, Ying-dong Jia, Xiao-jun Shang, Yong-li Shi & Xi-qing Yan

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  1. Bei-bei Hao
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  2. Xiu-zhen Deng
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Correspondence to Xi-qing Yan.

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Hao, Bb., Deng, Xz., Yang, Jk. et al. Preparation of Folic Conjugated Magnetic Silica Mesoporous Nanoparticles and Their Encapsulated 10-HCPT Anticancer Behavior. J Inorg Organomet Polym 32, 2986–2993 (2022). https://doi.org/10.1007/s10904-022-02338-5

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  • DOI: https://doi.org/10.1007/s10904-022-02338-5

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