Skip to main content
SpringerLink
Log in

Two Zn(II) Coordination Polymers: Luminescent Sensing Property and Treatment Activity on Uterine Leiomyomas by Reducing TGF-β Releasing and mmp-3 and mmp-7 Expression

  • Published:
Journal of Inorganic and Organometallic Polymers and Materials Aims and scope Submit manuscript

Abstract

Under solvothermal conditions, two new Zn(II)-based coordination polymers, namely {[Zn(tptc)0.5(2,2′-bpy)]·dioxane}n (1, H4tptc = p-terphenyl-2,2″,5″,5‴-tetracarboxylate acid, 2,2′-bpy = 2,2′-bipyridine) and [Zn(tptc)0.5(bib)]n (2, bib = 1,3-bis((imidazol-1-yl) benzene), have been synthesized using the mixed-ligand approach. Furthermore, the luminescence studies show that complex 2 can test acetylacetone selectively and sensitively, and the detection limit is 1.72 ppm. In addition, we evaluated the compounds therapeutic effect against uterine leiomyomas. The uterine leiomyomas rats model was established, the compound 1 and compound 2 was used for treatment. The detection of the transforming growth factor-β (TGF-β) releasing from endometrial stromal cells into plasma was detected with an enzyme linked immunosorbent assay (ELISA) detection kit. Then, the mmp-3 and mmp-7 relative expression levels in the uterine smooth muscle cells after compound treatment were measured by the reverse transcription-polymerase chain reaction (RT-PCR).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Figure 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

Data Availability

The data used to support the findings of this study are included within the article.

References

  1. D. Le, C.B. Dey, K. Byun, Imaging findings of a torsed pedunculated uterine leiomyoma: a case report. Radiol Case Rep 15, 144–149 (2020)

    Article  Google Scholar 

  2. P.E. Ludwig, T.J. Huff, M.M. Shanahan, J.M. Stavas, Pregnancy success and outcomes after uterine fibroid embolization: updated review of published literature. Br. J. Radiol. 93, 20190551 (2020)

    Article  Google Scholar 

  3. P.H. Lin, Y.T. Tung, H.Y. Chen, Y.F. Chiang, H.C. Hong, K.C. Huang, S.P. Hsu, T.C. Huang, S.M. Hsia, Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation. J. Pineal. Res. 68, e12620 (2020)

    Article  CAS  Google Scholar 

  4. H. Liu, Y. Chen, L. Yang, W. Fu, 18F-NaF uptake in retroperitoneal neurofibroma and uterine leiomyoma calcifications. Clin. Nucl. Med. 44, 991–992 (2019)

    Article  Google Scholar 

  5. Y.S. Shi, Y.H. Li, G.H. Cui, G.Y. Dong, New two-dimensional Cd(ii) coordination networks bearing benzimidazolyl-based linkers as bifunctional chemosensors for the detection of acetylacetone and Fe3+. CrystEngComm 22, 905–914 (2020)

    Article  CAS  Google Scholar 

  6. Y.S. Shi, D. Liu, L. Fu, Y.H. Li, G.Y. Dong, Five water-stable luminescent Cd(II)-based metal–organic frameworks as sensors for highly sensitive and selective detection of acetylacetone, Fe3+ and Cr2O72− ions. CrystEngComm 22, 4079–4093 (2020)

    Article  CAS  Google Scholar 

  7. D. Yuan, M. Sun, M. Zhao, S. Tang, J. Qi, X. Zhang, K. Wang, B. Li, Persulfate promoted ZnIn2S4 visible light photocatalytic dye decomposition. Int. J. Electrochem. Sci. 15, 8761–8770 (2020)

    Article  Google Scholar 

  8. N. Jiang, Y. Liu, X.N. Yu, H.B. Zhang, M.M. Wang, Corrosion resistance of nickel-phosphorus/nano-ZnO composite multilayer coating electrodeposited on carbon steel in acidic chloride environments. Int. J. Electrochem. Sci. 15, 5520–5528 (2020)

    Article  CAS  Google Scholar 

  9. J.X. Li, Z.X. Du, A binuclear cadmium(II) cluster based on π···π stacking and Halogen···Halogen interactions: synthesis, crystal analysis and fluorescent properties. J. Clust. Sci. 31, 507–511 (2020)

    Article  CAS  Google Scholar 

  10. J.X. Li, Z.X. Du, X. Feng, A new binuclear Ni(II) complex with tetrafluorophthalate and 2,2′-bipyridine ligands: synthesis, crystal structure and magnetic properties. Z. Naturforsch. 74, 833–838 (2019)

    Article  CAS  Google Scholar 

  11. J.X. Li, Z.X. Du, J. Wang, X. Feng, Two mononuclear zinc(II) complexes constructed by two types of phenoxyacetic acid ligands: syntheses, crystal structures and fluorescence properties. Z. Naturforsch. 74, 839–845 (2019)

    Article  CAS  Google Scholar 

  12. J.X. Li, Z.X. Du, Zinc and cobalt complexes with (2-carboxyphenoxy) acetic acid ligand: syntheses, structures, fluorescent and magnetic properties. J. Coord. Chem. 69, 2563–2572 (2016)

    Article  CAS  Google Scholar 

  13. C. Duan, Z. Su, Y. Cao, L. Hu, D. Fu, J. Ma, Y. Zhang, Synthesis of core-shell α-AlH3@Al(OH)3 nanocomposite with improved low-temperature dehydriding properties by mechanochemical mixing and ionic liquid treatment. J. Clean. Prod. 283, 124635 (2021)

    Article  CAS  Google Scholar 

  14. L. Fan, Z. Liu, Y. Zhang, D. Zhao, J. Yang, X. Zhang, p-Terphenyl-2,2″,5″,5‴-tetracarboxylate acid based bifunctional 1D Zinc(II) metal-organic platform for luminescent sensing and gas adsorption. Inorg. Chem. Commun. 107, 107463 (2019)

    Article  CAS  Google Scholar 

  15. L. Fan, Y. Zhang, J. Wang, L. Zhao, X. Wang, T. Hu, X. Zhang, Modular construction, magnetic property, and luminescent sensing of 3D Mn(II) and Cd(II) coordination polymers based on p-terphenyl-2,2″,5″,5‴-tetracarboxylate acid. J. Solid State Chem. 260, 46–51 (2018)

    Article  CAS  Google Scholar 

  16. J.C. Jin, J. Wu, Y.X. He, B.H. Li, J.Q. Liu, R. Prasad, A. Kumar, S.R. Batten, A 3D luminescent Zn(ii) MOF for the detection of high explosives and the degradation of organic dyes: an experimental and computational study. CrystEngComm 19, 6464–6472 (2017)

    Article  CAS  Google Scholar 

  17. Z.Q. Liu, Y. Zhao, Y. Deng, X.D. Zhang, Y.S. Kang, Q.Y. Lu, W.Y. Sun, Selectively sensing and adsorption properties of nickel(II) and cadmium(II) architectures with rigid 1H-imidazol-4-yl containing ligands and 1,3,5-tri(4-carboxyphenyl)benzene. Sens. Actuator B 250, 179–188 (2017)

    Article  CAS  Google Scholar 

  18. J. Wang, L.M. Wang, C. Lu, H.J. Yan, S.X. Wang, D. Wang, Formation of multicomponent 2D assemblies of C2v-symmetric terphenyl tetracarboxylic acid at the solid/liquid interface: recognition, selection, and transformation. RSC Adv. 9, 11659–11663 (2019)

    Article  CAS  Google Scholar 

  19. Q.Q. Xiao, G.Y. Dong, Y.H. Li, G.H. Cui, Cobalt(II)-based 3D coordination polymer with unusual 4,4,4-connected topology as a dual-responsive fluorescent chemosensor for acetylacetone and Cr2O72–. Inorg. Chem. 58, 15696–15699 (2019)

    Article  CAS  Google Scholar 

  20. Y.J. Yang, Y.H. Li, D. Liu, G.H. Cui, A dual-responsive luminescent sensor based on a water-stable Cd(ii)-MOF for the highly selective and sensitive detection of acetylacetone and Cr2O72− in aqueous solutions. CrystEngComm 22, 1166–1175 (2020)

    Article  CAS  Google Scholar 

  21. X.J. Wei, D. Liu, Y.H. Li, G.H. Cui, New 2D and 3D Cd(II) coordination polymers from aromatic dicarboxylate and 1,3-bis(5,6-dimethylbenzimidazol-1-yl)-2-propanol ligands: Syntheses, structures, photocatalytic, and luminescence sensing properties. J. Solid State Chem. 272, 138–147 (2019)

    Article  CAS  Google Scholar 

  22. M.Y. Sun, D.M. Chen, A porous Zn(II)-based metal–organic framework for highly selective and sensitive Fe3+ ion detection in water. Polyhedron 147, 80–85 (2018)

    Article  CAS  Google Scholar 

  23. A.K. Bharati, L.P. Somnath, K.A. Siddiqui, A novel mixed ligand Zn-coordination polymer: synthesis, crystal structure, thermogravimetric analysis and photoluminescent properties. Inorg. Chim. Acta 500, 119219 (2020)

    Article  CAS  Google Scholar 

  24. K. Wu, J. Hu, S. Shi, J. Li, X. Cheng, A thermal stable pincer-MOF with high selective and sensitive nitro explosive TNP, metal ion Fe3+ and pH sensing in aqueous solution. Dye Pigment 173, 107993 (2020)

    Article  CAS  Google Scholar 

  25. W.J. Ji, G.F. Liu, B.Q. Wang, W.B. Lu, Q.G. Zhai, Design of a heterometallic Zn/Ca-MOF decorated with alkoxy groups on the pore surface exhibiting high fluorescence sensing performance for Fe3+ and Cr2O72−. CrystEngComm 22, 4710–4715 (2020)

    Article  CAS  Google Scholar 

  26. Y.S. Shi, Z.C. Hao, C. Han, G.H. Cui, Synthesis, crystal structures, and luminescence sensing properties of two metal complexes containing bis(thiabendazole) moieties. J. Mol. Struct. 1201, 127218 (2020)

    Article  CAS  Google Scholar 

  27. X. Liang, Y. Jia, Z. Zhan, M. Hu, A highly selective multifunctional Zn-coordination polymer sensor for detection of Cr (III), Cr (VI) ion, and TNP molecule. Appl. Organomet. Chem. 33, 15399–15402 (2019)

    Article  Google Scholar 

  28. Y.N. Wang, S.D. Wang, Y.M. Gao, L.L. Yang, L.X. Xie, 3D Cadmium(II)-based coordination polymer constructed from V-shaped semirigid ligand: selective detection of oxoanion pollutants CrO42-, Cr2O72-, MnO4- in water. Zeitschrift Für Anorg Und Allg Chemie 645, 1358–1364 (2019)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Obstetrics and Gynecology Medicine, The Fourth People’s Hospital of Jinan, Jinan, Shandong, China

    Min Li & Hui Jiao

  2. Department of Medicine, Qingdao University, Qingdao, Shandong, China

    Xiao Wei & Xiufeng Yang

Authors
  1. Min Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hui Jiao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiao Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiufeng Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hui Jiao.

Ethics declarations

Conflict of interest

The author declares that there is no conflict of interest regarding the publication of this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary Information 1 (DOCX 34426 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, M., Jiao, H., Wei, X. et al. Two Zn(II) Coordination Polymers: Luminescent Sensing Property and Treatment Activity on Uterine Leiomyomas by Reducing TGF-β Releasing and mmp-3 and mmp-7 Expression. J Inorg Organomet Polym 31, 2831–2841 (2021). https://doi.org/10.1007/s10904-021-01932-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10904-021-01932-3

Keywords

Search

Navigation