Abstract
We report a series of SBA-15 type mesoporous silica (MS) possessing functional annulated rings of different sizes obtained by post-synthesis grafting with diamines containing backbones and different numbers of carbon atoms as efficient magnetic resonance imaging (MRI) contrasting agents. Interestingly, lanthanide ion adsorption assays in aqueous solutions of pH 7 at room temperature showed that adsorption efficiency was higher for materials with rings than those without rings. Furthermore, annulated MS synthesized with 1,5-diaminopetane exhibited selective chelation with smaller Yb(III) ions owing to the “macrocyclic effect” of the cation cavity that offers a “best fit.” Additionally, Gd(III) ions chelated with the material modified by 1, 5-diaminopetane denoted as Gd@annulated-MS exhibited high r2/r1 relaxivities of 12, 12, and 28 while measured with 7.0 T (300 MHz), 9.4 T (400 MHz), and 11.4 T (500 MHz), respectively. Finally, the nanoscale parent materials for annulated modification were successfully synthesized for further in vivo applications. The MS materials thus obtained open auxiliary avenues for selective lanthanide ion absorption via manipulation of the annular ring size to be potentially applied in new generation MRI contrast agents.
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Acknowledgments
We would like to thank the Ministry of Science and Technology (MOST) for the funding support (103-2113-M-008-001; 104-2119-M-008-010). For T1/T2 measurements, we thank Ms. Jenny Wu at Instrument Development Center in National Cheng Kung University, Taiwan, and S. M. A. and Y. Y. extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for funding this Prolific Research Group (PRG-1436-19).
Author Contributions
S C. Wang and Y. S. Hsu contributed to the sample synthesis. C. T. Hsiao, C. C. Wu, and Y. C. Sue contributed to the SEM and TEM images. S. M. Alshehri and Y. Yamauchi contributed to figures revision. S. C. Wang, S. M. Alshehri, Y. Yamauchi, and F. K. Shieh primarily wrote the manuscript, which was revised by J. E. Chen, K. C. W. Wu and F. K. Shieh. All authors contributed to discussions and manuscript review.
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Wang, SC., Hsu, YS., Hsiao, CT. et al. Annulated Mesoporous Silica as Potent Lanthanide Ion Adsorbents and Magnetic Resonance Contrast Enhancing Agents. J Inorg Organomet Polym 26, 165–171 (2016). https://doi.org/10.1007/s10904-015-0280-8
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DOI: https://doi.org/10.1007/s10904-015-0280-8