Abstract
A new Zn(II)-bearing metal-organic framework (MOF), namely, {[Zn2(L)2(H2O)]·8H2O·DMF}n (1) has been generated via applying 4,4′-([2,3′-bipyridine]-4,6-diyl) dibenzoic acid (H2L), a pyridine-carboxylic acid ligand under the solvothermal reaction conditions. In the aqueous solution, complex 1 could be utilized as the fluorescent sensor for the simultaneous detection of Cr2O72− ion and CrO42− ion with low limits of detection and high sensitivity. It is important that this luminescent material can be regenerated quickly and the sensing ability of this luminescent material can be reused for three times. Furthermore, the assessment of the compound’s application values against the Tuberculosis care was carried out and simultaneously its relevant mechanism was investigated. First of all, the bacterial burden in the lung macrophages was measured with plate micro-dilution method. Besides, the signaling pathway of JAK/STAT activation was evaluated with real time RT-PCR. Molecular docking simulation reveals that the polar oxygens are the active sites that could form binding interactions the protein.
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The data used to support the findings of this study are included within the article.
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The data that support the findings of this study have been deposited in NCBI Reference Sequence: NC_000002.12.
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Jin-Chao Mao and Jin-Jing Hong carried out the experiments, analyzed the data and wrote the draft of this manuscript; Ming-Zheng Lin, Feng Han and Dong Li designed the whole experiments and revised the draft.
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We try to replace live animals with unconscious experimental materials, or use lower animals to replace higher animals. we try to use the smallest number of animals to get the same amount of experimental data or use a certain number of animals to get more experimental data. We minimize the scope and extent of the impact of inhumane procedures on animals. All the preformation conducted in this present research was approved by the Animal Ethics Committee of Affiliated Hospital of Nanjing University (Nanjing, China) with the No. 20200233.
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Mao, JC., Hong, JJ., Lin, MZ. et al. A luminescent Zn(II)-Containing Complex: Selective Sensing of Cr(VI) Anion and Application Values on Tuberculosis Care Through Increasing the Antibacterial Response of Macrophages. J Fluoresc 31, 1169–1176 (2021). https://doi.org/10.1007/s10895-021-02750-z
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DOI: https://doi.org/10.1007/s10895-021-02750-z