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Pyrimidine Derivative Schiff Base Ligand Stabilized Copper and Nickel Nanoparticles by Two Step Phase Transfer Method; in Vitro Anticancer, Antioxidant, Anti-Microbial and DNA Interactions

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Abstract

Pyrimidine derivative Schiff base ligand (DPMC) stabilized metal nanoparticles of copper (DPMC-CuNPs) and nickel (DPMC-NiNPs) were synthesized by modified Brust-Schiffrin technique, which is a two-step phase transfer assisted synthesis. The prepared metal nanoparticles were confirmed by UV-Visible and Infrared spectroscopy. The size, surface morphology and the quality of the DPMC and its MNPs were analyzed by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) methods respectively. Electrochemical behavior of the DPMC-CuNPs and DPMC-NiNPs was analyzed by cyclic voltammetry method. DNA binding studies of the synthesized compounds with CT-DNA were examined by four different techniques such as UV-Visible and emission spectroscopy, cyclic voltametry and viscometric measurments. Thermal denaturation and sono-chemical denaturation studies of DNA with the DPMC, DPMC-CuNPs and DPMC-NiNPs results also suggest the synthesized compounds have good DNA binding ability. Various antioxidant scavenging studies results shows that DPMC and its copper and nickel nanoparticles have significant antioxidant activity. Antimicrobial studies of the DPMC and its MNPs were studied by Agar-Agar well diffusion method. Anticancer studies of the DPMC and its MNPs show that the DPMC-CuNPs and DPMC-NiNPs have significant anticancer activity with least toxicity than the standard drug cis-platin.

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Acknowledgements

The authors express their sincere and heartfelt thanks to Managing Board, Principal, Head and staff members, The American College, Madurai for providing the research facilities and their constant encouragements. Authors acknowledge the Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India and also authors acknowledge the Managing Board, Dean, Principal, Head and staff members of Department of Chemistry, Mohamed Sathak Engineering College, Kilakarai for providing research facilities. The authors express their sincere thanks to Department of Scienceand Technology (DST)-Science and Engineering Research Board (SERB Ref. No.: SR/FT/CS-117/2011 dated 29.06.2012) Government of India, New Delhi for the financial support.

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Authors and Affiliations

  1. Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, 600 041, India

    Adwin Jose P. & Sukkur Saleem S.

  2. Chemistry Research Centre, Mohamed Sathak Engineering College, Ramanathapuram (District), Kilakarai, Tamil Nadu, 623 806, India

    Adwin Jose P.

  3. Department of Chemistry, K. Ramakrishnan College of Technology, Samayapuram, Trichy, Tamil Nadu, 621 112, India

    Sankarganesh M.

  4. Department of Chemistry, The American College, Tallakulam, Madurai, Tamil Nadu, 625 002, India

    Dhaveethu Raja J.

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  1. Adwin Jose P.
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Correspondence to Dhaveethu Raja J..

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Highlights

• Solid air stable metal nano particles of copper and nickel were prepared.

• The nano particles was stabilized by pyrimidine derivative Schiff base ligand

• Stabilized nanoparticles were readily soluble in most of the solvents.

• Synthesized metal nanoparticles have good antibacterial activity.

• Both metal nanoparticles have least toxicity than cis-platin.

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P., A., M., S., J., D. et al. Pyrimidine Derivative Schiff Base Ligand Stabilized Copper and Nickel Nanoparticles by Two Step Phase Transfer Method; in Vitro Anticancer, Antioxidant, Anti-Microbial and DNA Interactions. J Fluoresc 30, 471–482 (2020). https://doi.org/10.1007/s10895-020-02510-5

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  • DOI: https://doi.org/10.1007/s10895-020-02510-5

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