Abstract
This study compares the proportions of surgical intensive care unit (ICU) patients with delirium detected using the Confusion Assessment Method for the ICU (CAM-ICU) who received administrative documentation for delirium using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes, stratified by delirium motoric subtypes. This retrospective cohort study was conducted at a surgical ICU from 06/2012 to 05/2013. Delirium was assessed twice daily and was defined as having ≥1 positive CAM-ICU rating. Delirious patients were categorized into hyperactive/mixed and hypoactive subtypes using corresponding Richmond Agitation Sedation Scales. Administrative documentation of delirium was defined as having ≥1 of 32 unique ICD-9-CM codes. Proportions were compared using Pearson’s Chi-square test. Of included patients, 40 % (423/1055) were diagnosed with delirium, and 17 % (183/1055) had an ICD-9-CM code for delirium. The sensitivity and specificity of ICD-9-CM codes for delirium were 36 and 95 %. ICD-9-CM codes for delirium were available for 42 % (95 % CI 35–48 %; 105/253) of patients with hyperactive/mixed delirium and 27 % (95 % CI 20–34 %; 46/170) of patients with hypoactive delirium (relative risk = 1.5; 95 % CI 1.2–2.0; p = 0.002). ICD-9-CM codes yielded a low sensitivity for identifying patients with CAM-ICU positive delirium and were more likely to identify hyperactive/mixed delirium compared with hypoactive delirium.
Similar content being viewed by others
References
McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK. Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc. 2003;51(5):591–8.
Landro L. Changing intensive care to improve life afterward. Wall Street J. 2011. http://online.wsj.com/article/SB10001424052748704081604576144321242020948.html. Accessed 10 March 2016.
Moyer J. Hospitals fight a form of delirium that often strikes ICU patients. The Washington Post. 2011. http://www.washingtonpost.com/national/health/hospitals-fight-a-form-of-delirium-that-often-strikesicu-patients/2011/03/23/AF518nMD_story.html. Accessed 10 March 2016.
Barr J, Fraser GL, Puntillo K, Ely EW, Gelinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R, American College of Critical Care M. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263–306. doi:10.1097/CCM.0b013e3182783b72.
Salluh JI, Soares M, Teles JM, Ceraso D, Raimondi N, Nava VS, Blasquez P, Ugarte S, Ibanez-Guzman C, Centeno JV, Laca M, Grecco G, Jimenez E, Arias-Rivera S, Duenas C, Rocha MG, Delirium Epidemiology in Critical Care Study G. Delirium epidemiology in critical care (DECCA): an international study. Crit Care. 2010;14(6):R210. doi:10.1186/cc9333.
Lat I, McMillian W, Taylor S, Janzen JM, Papadopoulos S, Korth L, Ehtisham A, Nold J, Agarwal S, Azocar R, Burke P. The impact of delirium on clinical outcomes in mechanically ventilated surgical and trauma patients. Crit Care Med. 2009;37(6):1898–905. doi:10.1097/CCM.0b013e31819ffe38.
Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Inouye SK, Bernard GR, Dittus RS. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291(14):1753–62. doi:10.1001/jama.291.14.1753.
Thomason JW, Shintani A, Peterson JF, Pun BT, Jackson JC, Ely EW. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care. 2005;9(4):R375–81. doi:10.1186/cc3729.
van den Boogaard M, Peters SA, van der Hoeven JG, Dagnelie PC, Leffers P, Pickkers P, Schoonhoven L. The impact of delirium on the prediction of in-hospital mortality in intensive care patients. Crit Care. 2010;14(4):R146. doi:10.1186/cc9214.
Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, Investigators B-IS. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;369(14):1306–16. doi:10.1056/NEJMoa1301372.
Milbrandt EB, Deppen S, Harrison PL, Shintani AK, Speroff T, Stiles RA, Truman B, Bernard GR, Dittus RS, Ely EW. Costs associated with delirium in mechanically ventilated patients. Crit Care Med. 2004;32(4):955–62.
Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med. 2009;180(11):1092–7. doi:10.1164/rccm.200904-0537OC.
Shehabi Y, Riker RR, Bokesch PM, Wisemandle W, Shintani A, Ely EW, Group SS. Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med. 2010;38(12):2311–8. doi:10.1097/CCM.0b013e3181f85759.
Ouimet S, Kavanagh BP, Gottfried SB, Skrobik Y. Incidence, risk factors and consequences of ICU delirium. Intensive Care Med. 2007;33(1):66–73. doi:10.1007/s00134-006-0399-8.
Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104(1):21–6.
Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population. Crit Care Med. 2009;37(1):177–83. doi:10.1097/CCM.0b013e318192fcf9.
Potter J, George J, Guideline Development G. The prevention, diagnosis and management of delirium in older people: concise guidelines. Clin Med. 2006;6(3):303–8.
Swan JT. Decreasing inappropriate unable-to-assess ratings for the confusion assessment method for the intensive care unit. Am J Crit Care. 2014;23(1):60–9. doi:10.4037/ajcc2014567.
Swan JT, Fitousis K, Hall JB, Todd SR, Turner KL. Antipsychotic use and diagnosis of delirium in the intensive care unit. Crit Care. 2012;16(3):R84. doi:10.1186/cc11342.
Meagher DJ, O’Hanlon D, O’Mahony E, Casey PR, Trzepacz PT. Relationship between symptoms and motoric subtype of delirium. J Neuropsychiatry Clin Neurosci. 2000;12(1):51–6. doi:10.1176/jnp.12.1.51.
Meagher DJ, Trzepacz PT. Motoric subtypes of delirium. Semin Clin Neuropsychiatry. 2000;5(2):75–85. doi:10.153/SCNP00500075.
O’Keeffe ST, Lavan JN. Clinical significance of delirium subtypes in older people. Age Ageing. 1999;28(2):115–9.
Peterson JF, Pun BT, Dittus RS, Thomason JW, Jackson JC, Shintani AK, Ely EW. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc. 2006;54(3):479–84. doi:10.1111/j.1532-5415.2005.00621.x.
Robinson TN, Raeburn CD, Tran ZV, Brenner LA, Moss M. Motor subtypes of postoperative delirium in older adults. Arch Surg. 2011;146(3):295–300. doi:10.1001/archsurg.2011.14.
Pandharipande P, Cotton BA, Shintani A, Thompson J, Costabile S, Truman Pun B, Dittus R, Ely EW. Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients. Intensive Care Med. 2007;33(10):1726–31. doi:10.1007/s00134-007-0687-y.
Lin SM, Liu CY, Wang CH, Lin HC, Huang CD, Huang PY, Fang YF, Shieh MH, Kuo HP. The impact of delirium on the survival of mechanically ventilated patients. Crit Care Med. 2004;32(11):2254–9.
Liptzin B, Levkoff SE. An empirical study of delirium subtypes. Br J Psychiatry. 1992;161:843–5.
Morandi A, Pandharipande P, Trabucchi M, Rozzini R, Mistraletti G, Trompeo AC, Gregoretti C, Gattinoni L, Ranieri MV, Brochard L, Annane D, Putensen C, Guenther U, Fuentes P, Tobar E, Anzueto AR, Esteban A, Skrobik Y, Salluh JI, Soares M, Granja C, Stubhaug A, de Rooij SE, Ely EW. Understanding international differences in terminology for delirium and other types of acute brain dysfunction in critically ill patients. Intensive Care Med. 2008;34(10):1907–15. doi:10.1007/s00134-008-1177-6.
Boustani M, Baker MS, Campbell N, Munger S, Hui SL, Castelluccio P, Farber M, Guzman O, Ademuyiwa A, Miller D, Callahan C. Impact and recognition of cognitive impairment among hospitalized elders. J Hosp Med. 2010;5(2):69–75. doi:10.1002/jhm.589.
Fick DM, Kolanowski AM, Waller JL, Inouye SK. Delirium superimposed on dementia in a community-dwelling managed care population: a 3-year retrospective study of occurrence, costs, and utilization. J Gerontol A Biol Sci Med Sci. 2005;60(6):748–53.
Heisler CA, Melton LJ 3rd, Weaver AL, Gebhart JB. Determining perioperative complications associated with vaginal hysterectomy: code classification versus chart review. J Am Coll Surg. 2009;209(1):119–22. doi:10.1016/j.jamcollsurg.2009.03.017.
Inouye SK, Leo-Summers L, Zhang Y, Bogardus ST Jr, Leslie DL, Agostini JV. A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method. J Am Geriatr Soc. 2005;53(2):312–8. doi:10.1111/j.1532-5415.2005.53120.x.
Lin RY, Heacock LC, Fogel JF. Drug-induced, dementia-associated and non-dementia, non-drug delirium hospitalizations in the United States, 1998–2005: an analysis of the national inpatient sample. Drugs Aging. 2010;27(1):51–61. doi:10.2165/11531060-000000000-00000.
Redelmeier DA, Thiruchelvam D, Daneman N. Delirium after elective surgery among elderly patients taking statins. CMAJ. 2008;179(7):645–52. doi:10.1503/cmaj.080443.
Romano PS, Chan BK, Schembri ME, Rainwater JA. Can administrative data be used to compare postoperative complication rates across hospitals? Med Care. 2002;40(10):856–67. doi:10.1097/01.MLR.0000027452.96163.A4.
Association AP. Diagnostic and statistical manual of mental disorders. 4th ed. Washington: American Psychiatric Association; 2000.
University Health System Consortium. 2015. Accessed 3 Sept 2015.
Elixhauser A, Steiner C, Harris DR, Coffey RM. Comorbidity measures for use with administrative data. Med Care. 1998;36(1):8–27.
Acknowledgments
Investigators would like to thank Harlan Sparrow IV, MA (Senior Outcomes Analyst II, Quality, Houston Methodist System) and Bob Smith, MA (Epic Clarity Project Team, Houston Methodist System) for conducting queries of the electronic medical record to provide data for this study. The authors would like to thank Mary Thomas, MSN, RN (Manager, Clinical Documentation Management Program, Houston Methodist Hospital) and Tessie Bautista, CCS, (Health Information Management Manager, Coding and Data Management, AHIMA-Approved ICD-10-CM Trainer, Houston Methodist Hospital) for advising on administrative database and coding process. Investigators would like to thank the Department of Pharmacy at Houston Methodist Hospital for providing administrative, intellectual, and information technology support. Investigators would like to thank the Texas Southern University Undergraduate Research Program for the awarded stipend to Lan N. Bui to support her effort in the study.
Funding
LNB received an intramural grant from Texas Southern University, Houston, Texas, USA supporting her efforts on this study and a travel grant from Texas Society of Critical Care Medicine (SCCM) to present study result at SCCM Congress at Phoenix, Arizona, USA in January 2015. Other authors received no other financial support for the research, authorship, and/or publication of this article.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Bui, L.N., Pham, V.P., Shirkey, B.A. et al. Effect of delirium motoric subtypes on administrative documentation of delirium in the surgical intensive care unit. J Clin Monit Comput 31, 631–640 (2017). https://doi.org/10.1007/s10877-016-9873-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10877-016-9873-1