Skip to main content
SpringerLink
Log in

A Feasible Strategy of Fabricating of Gold-Encapsulated Dextran/Polyvinyl Alcohol Nanoparticles for the Treatment and Care of Wound Healing

  • Original Paper
  • Published:
Journal of Cluster Science Aims and scope Submit manuscript

Abstract

Biomaterials, which can also be used for clinical management applications for wound healing, are encouraged by gold loaded nanoparticles. The present work describes the formulations of wound dressings based on Dextran (DEX)-polyvinyl alcohol (PVA) nanocluster encapsulated with gold (Au) nanocomposites. The Au solutions are fabricated in the DEX/PVA matrix using Gold nanoparticles (Au@DEX/PVA). The effects on DEX/PVA nanoparticles was investigated for various experimental limitations. Scanning electron microscopy (HR-SEM) measured DEX/PVA and Au@DEX/PVA nanoparticle sizes. In addition, for Gram-Positive and Negative bacterial, the antibacterial efficacy of DEX/PVA and Au@DEX/PVA was established. The in vitro viability studies of DEX/PVA and Au@DEX/PVA has been performed using non-cancerous NIH-3T3 cells. In addition, we investigated in vivo skin wound healing developed over 16 days in mouse models. Unlike untreated wounds, the Au@DEX/PVA-treated wounds with minor damage received accelerated healing. These results show that bandaging materials based on Au@DEX/PVA may be a possible advanced biomaterial for wound healing and implantation in an animal model for use in wound healing applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. V. A. Kostenko, M. Y. Sitnikova, E. A. Skorodumova, E. G. Skorodumova, A. N. Fedorov, L. P. Pivovarova, I. V. Osipova, O. B. Ariskina, A. V. Rysev, and A. S. Povzun (2019). Kardiologiia 59, 56.

    Article  CAS  Google Scholar 

  2. A. Walduck, P. Sangwan, Q. A. Vo, J. Ratcliffe, J. White, B. W. Muir, and N. Tran (2020). RSC Adv. 10, 33608.

    Article  Google Scholar 

  3. T. Waghule, V. K. Rapalli, G. Singhvi, P. Manchanda, N. Hans, S. K. Dubey, M. S. Hasnain, and A. K. Nayak (2019). J. Drug Deliv. Sci. Technol. 52, 303.

    Article  CAS  Google Scholar 

  4. K. Kalantari, E. Mostafavi, A. M. Afifi, Z. Izadiyan, H. Jahangirian, R. Rafiee-Moghaddam, and T. J. Webster (2020). Nanoscale 12, 2268–2291.

    Article  CAS  Google Scholar 

  5. Y. J. Son, J. W. Tse, Y. Zhou, W. Mao, E. K. F. Yim, and H. S. Yoo (2019). Biomater. Sci. 7, 4444.

    Article  CAS  Google Scholar 

  6. J. L. Narayana, J. Gopal, and H.-F. Wu (2012). Analyst 137, 3372.

    Article  CAS  Google Scholar 

  7. A. Asadi, M. Abdi, E. Kouhsari, P. Panahi, M. Sholeh, N. Sadeghifard, T. Amiriani, A. Ahmadi, A. Maleki, and M. Gholami (2020). J. Glob. Antimicrob. Resist. 22, 161.

    Article  Google Scholar 

  8. J. Zhao, G. Weng, J. Li, J. Zhu, and J. Zhao (2018). Mater. Sci. Eng. C 92, 983.

    Article  CAS  Google Scholar 

  9. D. Westmeier, S. Siemer, C. Vallet, J. Steinmann, D. Docter, J. Buer, S. K. Knauer, and R. H. Stauber (2020). Nanoscale Adv. 2, 5428.

    Article  CAS  Google Scholar 

  10. V. Alt, T. Bechert, P. Steinrücke, M. Wagener, P. Seidel, E. Dingeldein, E. Domann, and R. Schnettler (2004). Biomaterials 25, 4383.

    Article  CAS  Google Scholar 

  11. A. Shivaram, S. Bose, and A. Bandyopadhyay (2017). Acta Biomater. 58, 550.

    Article  CAS  Google Scholar 

  12. T. Molnar, D. Csuka, G. Pusch, L. Nagy, P. Garred, and Z. Illes (2020). J. Stroke Cerebrovasc. Dis. 29, 104951.

  13. G. Sener, S. A. Hilton, M. J. Osmond, C. Zgheib, J. P. Newsom, L. Dewberry, S. Singh, T. S. Sakthivel, S. Seal, K. W. Liechty, and M. D. Krebs (2020). Acta Biomater. 101, 262.

    Article  CAS  Google Scholar 

  14. S. A. G. Lambrechts, T. N. Demidova, M. C. G. Aalders, T. Hasan, and M. R. Hamblin (2005). Photochem. Photobiol. Sci. 4, 503.

    Article  CAS  Google Scholar 

  15. H. Liu, C. Wang, C. Li, Y. Qin, Z. Wang, F. Yang, Z. Li, and J. Wang (2018). RSC Adv. 8, 7533.

    Article  CAS  Google Scholar 

  16. J. Sonamuthu, Y. Cai, H. Liu, M. S. M. Kasim, V. R. Vasanthakumar, B. Pandi, H. Wang, and J. Yao (2020). Int. J. Biol. Macromol. 153, 1058.

    Article  CAS  Google Scholar 

  17. P. Chen, X. Shen, W. Xu, W. Yao, and N. Ma (2019). Int. J. Surg. 68, 63–71.

    Article  Google Scholar 

  18. H. Jeelani, N. Tabassum, D. Afroze, and F. Rashid (2020). Gene Rep. 20, 100775.

  19. A. Rajoo, S. Ramanathan, S. M. Mansor, and S. Sasidharan (2021). J. Ethnopharmacol. 266, 113414.

  20. L. K. Aerden, S. Wuite, S. Houthoofd, and G. A. Matricali (2020). Foot Ankle Surg. (2020). 27, 246.

  21. L. Rosselle, A. R. Cantelmo, A. Barras, N. Skandrani, M. Pastore, D. Aydin, L. Chambre, R. Sanyal, A. Sanyal, R. Boukherroub, and S. Szunerits (2020). Biomater. Sci. 8, 5911.

    Article  CAS  Google Scholar 

  22. L. Karner, S. Drechsler, M. Metzger, A. Hacobian, B. Schädl, P. Slezak, J. Grillari, and P. Dungel (2020). Photochem. Photobiol. Sci. 19, 1332.

    Article  CAS  Google Scholar 

  23. H. Kalita, A. Hazarika, R. Kandimalla, S. Kalita, and R. Devi (2018). RSC Adv. 8, 36791.

    Article  CAS  Google Scholar 

  24. A. Zia, M. Hasan, S. Ilyas, H. U. Siddiqui, B. Tappuni, S. Marsia, M. M. Zubair, S. Raza, R. R. Mustafa, Z. Q. Baloch, S. V. Deo, U. M. Sharma, and M. A. Sheikh (2019). Surg. Infect. (Larchmt). 21, 323.

    Article  Google Scholar 

  25. O. J. S. Pujji, K. K. Nakarmi, B. Shrestha, S. M. Rai, and S. L. A. Jeffery (2019). J. Burn Care Res. 40, 838.

    Article  Google Scholar 

  26. M. Riool, A. de Breij, P. H. S. Kwakman, E. Schonkeren-Ravensbergen, L. de Boer, R. A. Cordfunke, N. Malanovic, J. W. Drijfhout, P. H. Nibbering, and S. A. J. Zaat (2020). Biochim. Biophys. Acta 1862, 183282.

  27. Z. Xu, X. Zhao, X. Chen, Z. Chen, and Z. Xia (2017). RSC Adv. 7, 52266.

    Article  CAS  Google Scholar 

  28. H. Wang, L. Guo, Y. Wang, and L. Feng (2019). Biomater. Sci. 7, 3788.

    Article  CAS  Google Scholar 

  29. Y. Zhu, J. Zhang, J. Song, J. Yang, T. Xu, C. Pan, and L. Zhang (2017). J. Mater. Chem. B. 5, 8451.

    Article  CAS  Google Scholar 

  30. K. Yadav, S. Kumar, D. Mishra, M. Asad, M. Mitra, P. S. Yavvari, S. Gupta, M. Vedantham, P. Ranga, V. Komalla, S. Pal, P. Sharma, A. Kapil, A. Singh, N. Singh, A. Srivastava, L. Thukral, and A. Bajaj (2019). J. Med. Chem. 62, 1875–1886.

    Article  CAS  Google Scholar 

  31. R. M. Strobel, M. Leonhardt, A. Krochmann, K. Neumann, F. Speichinger, L. Hartmann, L. D. Lee, K. Beyer, S. Daum, M. E. Kreis, and J. C. Lauscher (2019). Ann. Surg. 272, 55.

    Article  Google Scholar 

  32. G. D. Overturf (2006). Infect. Dis. Fetus Newborn Infant. 347.

  33. S. Ridwan, A. Grote, and M. Simon (2019). World Neurosurg. https://doi.org/10.1016/j.wneu.2019.10.146.

    Article  PubMed  Google Scholar 

  34. M. J. C. Salles, J. Zurita, C. Mejía, and M. V. Villegas (2013). Epidemiol. Infect. 141, 2459.

    Article  CAS  Google Scholar 

  35. J. W. Betts, A. S. Sharili, R. M. La Ragione, and D. W. Wareham (2016). J. Nat. Prod. 79, 1702.

    Article  CAS  Google Scholar 

  36. C. Wang, J. Zhang, and Z. Liu (2019). Int. Wound J. (2019). https://doi.org/10.1111/iwj.13277.

  37. S. Kumar, J. Thakur, K. Yadav, M. Mitra, S. Pal, A. Ray, S. Gupta, N. Medatwal, R. Gupta, D. Mishra, P. Rani, S. Padhi, P. Sharma, A. Kapil, A. Srivastava, U. D. Priyakumar, U. Dasgupta, L. Thukral, and A. Bajaj (2019). ACS Biomater. Sci. Eng. 5, 4764.

    Article  CAS  Google Scholar 

  38. Z. Ma, J. Han, B. Chang, L. Gao, Z. Lu, F. Lu, H. Zhao, C. Zhang, and X. Bie (2017). ACS Infect. Dis. 3, 820.

    Article  CAS  Google Scholar 

  39. Z. Ahmed, R. Uwechue, P. Chandak, D. van Dellen, J. Barwell, S. Heap, L. Szabo, C. Hemsley, J. Olsburgh, N. Kessaris, and N. Mamode (2019). Ann. Surg. 272, 65.

    Article  Google Scholar 

  40. M. K. Mohamed Subarkhan, L. Ren, B. Xie, C. Chen, Y. Wang, and H. Wang (2019). Eur. J. Med. Chem. 179, 246.

    Article  CAS  Google Scholar 

  41. M. K. Mohamed Subarkhan, R. Ramesh, and Y. Liu (2016). New J Chem. https://doi.org/10.1039/c6nj01936f.

    Article  Google Scholar 

  42. M. S. Mohamed Kasim, S. Sundar, and R. Rengan (2018). Inorg. Chem. Front. 5, 585.

    CAS  Google Scholar 

  43. M. K. M. Subarkhan and R. Ramesh (2016). Inorg. Chem. Front. 3, 1245.

    Article  CAS  Google Scholar 

  44. T. Sathiya Kamatchi, M. K. Mohamed Subarkhan, R. Ramesh, H. Wang, and J. G. Małecki (2020). Dalt. Trans. 49, 11385.

  45. Y. Gao, Z. Li, J. Huang, M. Zhao, and J. Wu (2020). J. Mater. Chem. B 8, 8768.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Infection, Wenling First People’s Hospital, No.333, Chuanan South Road, Chengxi Street, Wenling, 317500, China

    Chenxi Xia, Na Liu & Ying Zheng

  2. Department of Hepatobiliary Surgery, Wenling First People’s Hospital, Wenling, 317500, China

    Bei Ren

Authors
  1. Chenxi Xia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bei Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Na Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ying Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Na Liu or Ying Zheng.

Ethics declarations

Conflict of the interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xia, C., Ren, B., Liu, N. et al. A Feasible Strategy of Fabricating of Gold-Encapsulated Dextran/Polyvinyl Alcohol Nanoparticles for the Treatment and Care of Wound Healing. J Clust Sci 33, 2179–2187 (2022). https://doi.org/10.1007/s10876-021-02132-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10876-021-02132-2

Keywords

Search

Navigation