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An Effective Wound Healing Material Based on Gold Incorporation into a Heparin-Polyvinyl Alcohol Nanocomposite: Enhanced In Vitro and In Vivo Care of Perioperative Period

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Abstract

In this study, a highly porous heparin-polyvinylalcohol@gold nanocomposite (H-PVA@Au) bandage was fabricated by incorporating Au into H-PVA hydrogel for burn injury. The effects of the H-PVA hydrogel and Au nanoparticle composition on the functional group and surface properties of the as-prepared bandages were characterized by Fourier transform infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). The morphology of the H-PVA hydrogel and H-PVA@Au were evaluated using a scanning electron microscope (SEM) and transmission electron microscope (TEM). A study of the material properties of H-PVA hydrogel has shown that the presence of Au nanoparticles improves its toughness. Prepared H-PVA@Au nanoporous dressing has indicated good antimicrobial activity against types of bacteria (Staphylococcus aureus and Escherichia coli) and excellent biocompatibility with human dermal fibroblast cells (HFFF2) suitable for biological applications. Additionally, in vivo experiments using Kunming mice showed it as-prepared H-PVA@Au nanocomposite dressings improved wound healing and triggered skin cell development alongside collagen growth. Synergistic effects of the H-PVA@Au nanocomposite hydrogel dressing material through in vivo experiments, such as its excellent hydrophilic design, strong bactericidal activity, biocompatibility and wound healing ability, make it a promising candidate for the treatment of burn injuries.

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  1. Operating Room, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan City, 430071, China

    Kunxian Zhang & Guoyan Zhao

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Dr. GZ—Supervision, Investigation, Data curation, Formal analysis, validation, Software.

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All animal experiments were approved by the Ethics Committee of the Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan City-430071, China in accordance with the guidelines on animal care and use (File No: 2019-189).

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Zhang, K., Zhao, G. An Effective Wound Healing Material Based on Gold Incorporation into a Heparin-Polyvinyl Alcohol Nanocomposite: Enhanced In Vitro and In Vivo Care of Perioperative Period. J Clust Sci 33, 1655–1665 (2022). https://doi.org/10.1007/s10876-021-02078-5

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