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RETRACTED ARTICLE: Two Mixed-Ligand Co(II)-Based Coordination Polymers: Application Value in the Later Rehabilitation of Fracture Patients by Activating WNT Signaling Pathway

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This article was retracted on 01 February 2024

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Abstract

Two coordination polymers containing Co(II) ions as the metal source have been prepared by the hydrothermal reaction, and their chemical formulae are {[Co(Hnbta)(bimm)](3H2O)}n (1) and {[Co1.5(nbta)(pyim)(H2O)](2H2O)}n (2) (pyim = N-(4-pyridylmethyl)imidazole, bimm = bis(imidazol-1-yl)methane and H3nbta = 5-nitro-1,2,3-benzenetricarboxylic acid) and. The application values of the new compound in the later rehabilitation of fracture patients were assessed and the detailed mechanism was investigated as well. First of all, the Vascular endothelial growth factor (VEGF) content and Fibroblast growth factor (FGF) content was evaluated with enzyme linked immunosorbent assay (ELISA) detection kit, and the results indicated compound 1 was much stronger than compound 2 on increasing the VEGF and FGF content. In addition to this, the activation levels of the Wingless-type (Wnt) signaling pathway in mesenchymal stem cells was followed by western blotting assay, the data suggested that compound 1 could up-regulated the activation levels of the Wnt signaling pathway.

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Authors and Affiliations

  1. Department of Rehabilitation Medicine, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, China

    Juan Shen, Yu-Jun Qi, Zheng-Hua Kan & Chuan-Hao Bi

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  1. Juan Shen
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  2. Yu-Jun Qi
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  3. Zheng-Hua Kan
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Correspondence to Juan Shen.

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This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1007/s10876-024-02557-5

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Shen, J., Qi, YJ., Kan, ZH. et al. RETRACTED ARTICLE: Two Mixed-Ligand Co(II)-Based Coordination Polymers: Application Value in the Later Rehabilitation of Fracture Patients by Activating WNT Signaling Pathway. J Clust Sci 33, 37–43 (2022). https://doi.org/10.1007/s10876-020-01936-y

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  • DOI: https://doi.org/10.1007/s10876-020-01936-y

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