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Evaluation of Antioxidant, Anticancer and DNA Binding Potentials of Noble Metal Nanoparticles Synthesized Using Aristolochia indica and Indigofera tinctoria

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Abstract

The deployment of biological resources for the synthesis of nanoparticles of metals and metal oxides is the latest addition to green chemistry. The present work describes the use of aqueous stem extracts of Aristolochia indica and Indigofera tinctoria for the synthesis of silver and gold nanoparticles (Ag and Au NPs). The synthesized NPs were characterized by UV–Vis., FT-IR, TEM, XRD and EDAX analyzes. The antioxidant activities of functionalized Ag and Au NPs were studied by the DPPH method and the nanoparticles showed greater antioxidant activity than that of the extract; AgNPs synthesized by A. indica showed antioxidant activity of 84%. The in vitro cytotoxicity of the Ag and Au NPs was assessed by the MTT assay method using the HeLa cell line and the NPs synthesized by A. indica showed nearly 100% toxicity. DNA binding capacity was investigated using calf thymus-DNA by UV–Vis spectra, the hyperchromism shift inferred the groove binding of nanoparticles and the binding constants (1.66 × 107 and 1.06 × 107 and 0.77 × 107 and 1.59 × 107 M−1 for the NPs of Ag and Au synthesized by A. indica and I. tinctoria respectively) indicate a high potential of these nanoparticles for the administration of drugs.

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Acknowledgements

Priya Velammal acknowledges the University Grants Commission under Minor Project Scheme, [MRP-5333/14(SERO/UGC)]. The authors are grateful to King Saud University, Riyadh, Saudi Arabia for Researchers Supporting Project, (RSP-2020/68).

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Authors and Affiliations

  1. Post Graduate and Research Department of Chemistry, V.O. Chidambaram College, Tuticorin, Tamil Nadu, 628008, India

    Priya Velammal Subramanian & Peter Amaladhas Thomas

  2. Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box-2455, Riyadh, 11451, Kingdom of Saudi Arabia

    Mohamad S. AlSalhi & Sandhanasamy Devanesan

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  1. Priya Velammal Subramanian
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  2. Mohamad S. AlSalhi
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  3. Sandhanasamy Devanesan
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Subramanian, P., AlSalhi, M.S., Devanesan, S. et al. Evaluation of Antioxidant, Anticancer and DNA Binding Potentials of Noble Metal Nanoparticles Synthesized Using Aristolochia indica and Indigofera tinctoria. J Clust Sci 32, 917–927 (2021). https://doi.org/10.1007/s10876-020-01858-9

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