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A Systematic Study of Cu Nanospheres Embedded in Non-ionic Surfactant-Based Vesicle: Photocatalytic Efficiency and In Vivo Imaging Study

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Abstract

In this study, for the first time nanoparticles were synthesized and encapsulated in non-ionic surfactant-based vesicle (biology and chemistry). The non-ionic surfactant-based vesicle is formed mostly by non-ionic surfactant and cholesterol incorporation as an excipient by green capping agent. We researched a novel processing route for produce Cu nanospheres encapsulated in a non-ionic surfactant-based vesicle by glucose as a green capping reductant with microwave assisted reverse micelle method. The effect of glucose concentration and microwave power on the morphology, particle size, distribution and in vitro photoluminescence spectroscopy experiments of nanoparticles entrapped in the non-ionic surfactant-based vesicles were investigated. The synthesis parameters in this study were designed by Taguchi technique and various factors such as glucose concentration, temperature, microwave power and interaction between these factors were studied. The metal nanostructure with photocatalytic activity act as an emerging, non-invasive therapeutic strategy that involves photosensitizer drugs and external light for the treatment of cancer. The products were characterized by XRD, SEM, TEM, DLS, TGA and UV–Vis. The current study points out a successful example of using Cu nanospheres embedded in non-ionic surfactant-based vesicle as a new and novel nanomedicine material for in vivo imaging and the photocatalytic efficiency of methylene blue.

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Acknowledgements

Authors are grateful to council of Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Funding

This work was supported by the Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

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Authors and Affiliations

  1. Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran

    Hojjat Samareh Fekri

  2. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, P.O. Box 76175-493, Kerman, 76169-11319, Iran

    Mehdi Ranjbar & Abbas Pardakhty

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  1. Hojjat Samareh Fekri
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Correspondence to Mehdi Ranjbar.

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Samareh Fekri, H., Ranjbar, M. & Pardakhty, A. A Systematic Study of Cu Nanospheres Embedded in Non-ionic Surfactant-Based Vesicle: Photocatalytic Efficiency and In Vivo Imaging Study. J Clust Sci 30, 561–570 (2019). https://doi.org/10.1007/s10876-019-01507-w

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