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Human Disease Phenotypes Associated With Mutations in TREX1

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Abstract

Considering that it is a single exon gene encoding a 314 amino acid protein, the genotype-phenotype landscape of TREX1 is remarkably complex. Here we briefly describe the human diseases so-far associated with mutations in TREX1, which include Aicardi-Goutières syndrome, familial chilblain lupus, systemic lupus erythematosus and retinal vasculopathy with cerebral leukodystrophy.

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Acknowledgments

Y.J.C. acknowledges the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement 241779, the European Research Council (GA 309449: Fellowship to Y.J.C), and a state subsidy managed by the National Research Agency (France) under the “Investments for the Future” program bearing the reference ANR-10-IAHU-01.

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Authors and Affiliations

  1. Manchester Centre for Genomic Medicine, Institute of Human Development Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK

    Gillian I. Rice & Yanick J. Crow

  2. INSERM UMR 1163, Laboratory of Neurogenetics and Neuroinflammation, Institut Imagine, Hôpital Necker, Paris Descartes – Sorbonne Paris Cité University, Paris, France

    Mathieu P. Rodero & Yanick J. Crow

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  1. Gillian I. Rice
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Rice, G.I., Rodero, M.P. & Crow, Y.J. Human Disease Phenotypes Associated With Mutations in TREX1 . J Clin Immunol 35, 235–243 (2015). https://doi.org/10.1007/s10875-015-0147-3

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