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Associations of light physical activity, moderate-to-vigorous physical activity and sedentary behavior with quality of life in men on androgen deprivation therapy for prostate cancer: a quantile regression analysis

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Abstract

To examine associations of physical activity (PA) and sedentary time (SED) with quality of life (QoL) in men on androgen deprivation therapy (ADT) for prostate cancer. A pooled analysis of 106 men on ADT was conducted. PA and SED were assessed using accelerometers. The Functional Assessment of Cancer Therapy (FACT) was used to assess self-reported QoL. Quantile regression examined the associations of QoL with PA and SED. Total time spent in SED was positively associated with FACT-General at the 50th (p = 0.010) and 75th percentile (p = 0.022). SED in ≥ 30-min bouts was inversely associated with FACT-General at the 50th  (p = 0.025) and 75th percentile (p = 0.029). Breaks in SED were positively associated with physical well-being at the 75th percentile (p = 0.004). Light-intensity PA was positively associated with FACT-Prostate at the 25th percentile (p = 0.020). SED and PA were associated with QoL outcomes, but time in each varied across men reporting the poorest QoL compared to those in the highest QoL distributions.

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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank Mehala Subramaniapillai, Amna Iqbal, and Julia Duan for their assistance in conducting this study.

Funding

This work was funded by Prostate Cancer Canada. CMS is a Canada Research Chair in Physical Activity and Mental Health. GEF is supported by a Canadian Institutes of Health Research-Public Health Agency of Canada (CIHR-PHAC) Chair in Applied Public Health.

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Authors and Affiliations

  1. Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON, M5S 2W6, Canada

    Linda Trinh, Catherine M. Sabiston, Alexis Whitehorn & Denise Bastas

  2. Department of Medicine, University Health Network, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada

    Shabbir M. H. Alibhai

  3. Faculty of Kinesiology, University of Calgary, 376 Collegiate Blvd NW, Calgary, AB, T2N 1N4, Canada

    Nicole Culos-Reed

  4. Cancer Rehabilitation and Survivorship, Princess Margaret Cancer Centre, 610 University Ave, Toronto, ON, M5G 2C1, Canada

    Jennifer M. Jones

  5. Kaiser Permanente Washington Health Research Institute, 730 Minor Ave, Seattle, WA, 98101, USA

    Dori E. Rosenberg

  6. School of Kinesiology, University of British Columbia, 210-6081 University Boulevard, Vancouver, BC, V6T 1Z1, Canada

    Guy E. Faulkner

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  1. Linda Trinh
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Contributions

LT, SMHA, NCR, CMS, JMJ, DR, and GEF contributed to the conceptualization and design of the study. LT contributed to data analyses, drafting and revising the manuscript critically for important intellectual content. LT, SMHA, NCR, CMS, JMJ, DR, DB, AW, and GEF contributed to the interpretation of the data, and revising the manuscript critically for important intellectual content. All authors have read and approved the final manuscript.

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Correspondence to Linda Trinh.

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The recruitment sites were approved by each of the respective research ethics board (Human Research Ethics Committee; Protocol #: 29721). The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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All procedures followed were in accordance with ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all individual participants included in the study.

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Trinh, L., Alibhai, S.M.H., Culos-Reed, N. et al. Associations of light physical activity, moderate-to-vigorous physical activity and sedentary behavior with quality of life in men on androgen deprivation therapy for prostate cancer: a quantile regression analysis. J Behav Med 45, 533–543 (2022). https://doi.org/10.1007/s10865-022-00285-7

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