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Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

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Abstract

This study compared the quality of life (QoL) of HIV-infected patients with and without hepatitis C and examined the sociodemographic, HIV-related and psychological symptoms associated with the QoL domains in patients with HIV/HCV co-infection. The sample consisted of 248 HIV/HCV co-infected patients (18–74 years, 81.5 % male) and 482 patients only with HIV (24–78 years, 62.7 % male). Participants completed the WHOQOL-HIV-Bref questionnaire and the Brief Symptom Inventory. The HIV/HCV co-infected patients reported significantly lower QoL in all domains, as well as significantly lower scores in 10 of the 17 specific facets. Overall, among the co-infected patients, male gender, employment, combination antiretroviral therapy use and fewer depressive and anxiety symptoms were significantly associated with higher QoL. Symptoms of psychological distress accounted for significant variability in the QoL scores of co-infected patients. These data reinforce the need for tailored interventions to improve the overall well-being of HIV/HCV co-infected patients.

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Acknowledgments

This study was supported by Coordenação Nacional para a Infecção VIH/sida (Ref. 5-1.8.4/2007) and it was developed within the research group “Relationships, Development & Health”, of the R&D Unit CINEICC Cognitive and Behavioural Centre for Research and Intervention, University of Coimbra. Marco Pereira is a FCT Researcher (IF/00402/2014) and was supported by a Post-doctoral Scholarship from the Portuguese Foundation for Science and Technology (SFRH/BPD/44435/2008).

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Authors and Affiliations

  1. Faculty of Psychology and Educational Sciences, University of Coimbra, Rua do Colégio Novo, 3000-315, Coimbra, Portugal

    Marco Pereira

  2. School of Psychology, University of Sussex, Brighton, UK

    Renata Fialho

  3. Sussex Partnership NHS Foundation Trust, Brighton, UK

    Renata Fialho

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  1. Marco Pereira
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  2. Renata Fialho
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Correspondence to Marco Pereira.

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Marco Pereira and Renata Fialho declare that they do not have any conflict of interest

Human and animal rights and Informed consent

All procedures followed were in accordance with ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study

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Pereira, M., Fialho, R. Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection. J Behav Med 39, 767–781 (2016). https://doi.org/10.1007/s10865-016-9778-y

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