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Antioxidant efficacy of chitosan/graphene functionalized superparamagnetic iron oxide nanoparticles

  • Biomaterials Synthesis and Characterization
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Abstract

The antioxidant potential of superparamagnetic iron oxide nanoparticles functionalized with chitosan and graphene were examined in the present work. Coprecipitation technique was followed for the synthesis of iron oxide nanoparticles. Graphene-iron oxide nanocomposites were synthesized by mechanical mixing followed by the heat treatment at moderate temperature. The chitosan coated iron oxide nanoparticles were prepared by dispersing nanoparticles in chitosan solution. The nanoparticles/nanocomposites were characterized using XRD, SEM, TEM and HAADF-STEM for phase structure, morphology and elemental analysis. The superparamagnetic behavior of nanoparticles/nanocomposites were confirmed by magnetic measurements using vibrating sample magnetometry. Antioxidant efficacy of these nanoparticles/nanocomposites were investigated in terms of free radical scavenging and reducing potential using an array of in vitro assay system. Ferric reducing antioxidant power (FRAP) and 2,2′-diphenyl-1-picrylhydrazyl (DPPH) were used for the antioxidant capacity. The investigation suggests that the graphene improves the antiradical response of iron oxide nanoparticles at higher concentration which is almost comparable to the ascorbic acid used as standard.

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Acknowledgements

The authors are thankful to Mr. S.L. Gadge (Department of Metallurgical & Materials Engineering, VNIT Nagpur) for his constant support and motivation for the work.

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Author notes

  1. These authors contributed equally: Vikram Hastak and Suresh Bandi.

Authors and Affiliations

  1. Department of Metallurgical and Materials Engineering, VNIT, Nagpur, India

    Vikram Hastak, Suresh Bandi, D. R. Peshwe & Ajeet K. Srivastav

  2. Department of Physics, BML Munjal University, Gurgaon, India

    Sanjay Kashyap

  3. Department of Molecular Bioprospection, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India

    Shilpi Singh & Suaib Luqman

  4. Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai, India

    Mangesh Lodhe

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  1. Vikram Hastak
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Correspondence to Ajeet K. Srivastav.

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Hastak, V., Bandi, S., Kashyap, S. et al. Antioxidant efficacy of chitosan/graphene functionalized superparamagnetic iron oxide nanoparticles. J Mater Sci: Mater Med 29, 154 (2018). https://doi.org/10.1007/s10856-018-6163-0

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