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Effect of strontium substitution on the cytocompatibility and 3-D scaffold structure for the xSrO–(10−x) MgO–60SiO2–20CaO–10 P2O5 (2 ≤ x ≤ 8) sol–gel glasses

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

In the present study, novel glasses xSrO–(10−x) MgO–60SiO2–20CaO–10 P2O5 (2 ≤ x ≤ 8, in steps of 2) are synthesized via sol–gel method. The current work focusses on the evaluation of mechanical, physical and biocompatible properties for sol–gel glasses. The pore size and surface area of these glasses were studied using BET analysis. The structural aspect of the glasses/glass ceramics was studied by XRD and Raman spectroscopy. The cytotoxicity assays were conducted for MG63 human osteosarcoma cell line. Furthermore, the as prepared glasses were used for the fabrication of 3-D porous scaffolds via polymer replication method. The loaded green bodies have been sintered at 700, 800 and 900 °C and were kept for 6 h to densify the glass network. The effect of sintering temperature on the structure and properties of as prepared scaffolds were analyzed via scanning electron microscopy (SEM) and porosity calculations.

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Acknowledgements

The authors are thankful to Mr. Aayush Gupta for his valuable suggestions. One of the author GK is thankful to University Grant Commission (UGC) under the letter no. F 15/2013-2014/PDFWM – 2013-2014-GE – PUN – 14803 (SA-II) for providing financial assistance.

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Authors and Affiliations

  1. Department of Physics, Punjabi University, Patiala, 147002, Punjab, India

    Swati Thakur & Shikha Garg

  2. School of Physics & Materials Science, Thapar University, Patiala, 147004, Punjab, India

    Gurbinder Kaur & Om Prakash Pandey

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  1. Swati Thakur
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  2. Shikha Garg
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  4. Om Prakash Pandey
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Correspondence to Gurbinder Kaur or Om Prakash Pandey.

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Thakur, S., Garg, S., Kaur, G. et al. Effect of strontium substitution on the cytocompatibility and 3-D scaffold structure for the xSrO–(10−x) MgO–60SiO2–20CaO–10 P2O5 (2 ≤ x ≤ 8) sol–gel glasses. J Mater Sci: Mater Med 28, 89 (2017). https://doi.org/10.1007/s10856-017-5901-z

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