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In vitro bioactivity of titanium-doped bioglass

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Abstract

Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

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Authors and Affiliations

  1. Biomaterials Unit, School of Dentistry, University of Birmingham, Birmingham, UK

    Imran M. Asif, Richard M. Shelton, Paul R. Cooper & Owen Addison

  2. School of Engineering & Applied Science and Aston Research Centre for Healthy Ageing, University of Aston, Aston Triangle, Birmingham, UK

    Richard A. Martin

Authors
  1. Imran M. Asif
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  2. Richard M. Shelton
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  3. Paul R. Cooper
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  4. Owen Addison
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  5. Richard A. Martin
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Correspondence to Richard A. Martin.

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Asif, I.M., Shelton, R.M., Cooper, P.R. et al. In vitro bioactivity of titanium-doped bioglass. J Mater Sci: Mater Med 25, 1865–1873 (2014). https://doi.org/10.1007/s10856-014-5230-4

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  • DOI: https://doi.org/10.1007/s10856-014-5230-4

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