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Review of novel materials as photosensitizers towards the bottleneck of photodynamic therapy

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Abstract

Photodynamic therapy (PDT) is a safe and effective therapeutic option for the management of cancer and other diseases. However, the issues of light (dose and wavelength), tumour selectivity of photosensitizers (PSs), and tumour hypoxia limit its broad clinical application, especially in the therapy of deep-seated tumours. Photosensitizers (PSs) are the core components of PDT which yield 1O2 or cytotoxic radical to achieve photodynamic therapy. Therefore, to meet the clinical requirements, developing novel PSs is urgently needed. In this review, we describe 4 newly emergent PSs for PDT including aggregation-induced emission PS, near-infrared-II PS, nano-PS, and metal–organic framework PS, and strategies which hold promise solving the current issues of PDT. These PSs and strategies will aid the future research and provide the greatest hope for clinical transformation of PDT.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 81602846), Taishan Scholar Project of Shandong Province (No. tsqn201812159) and Natural Science Foundation of Shandong Province(ZR2020QH270,ZR2020QH166)and Projects of Medical and Health Technology Development Program in Shandong Province (2018WS471).

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  1. Hailiang Zhang and Wenxiu Han have contributed equally to this work and should be considered as co-first author.

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  1. Jining First People’s Hospital, Jining Medical University, Jining, 272000, China

    Hailiang Zhang, Wenxiu Han, Pengfei Xu & Pei Jiang

  2. Department of Medical Genetics, Zibo Maternity and Child Care Hospital, Zibo, 255000, China

    Jiajia Han

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ZH contributed to writing—original draft preparation and funding acquisition. HW contributed to writing—reviewing and editing, data curation, and funding acquisition. HJ contributed to methodology and software. XP contributed to visualization, investigation, and funding acquisition. JP contributed to supervision and funding acquisition.

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Zhang, H., Han, W., Han, J. et al. Review of novel materials as photosensitizers towards the bottleneck of photodynamic therapy. J Mater Sci 57, 14620–14654 (2022). https://doi.org/10.1007/s10853-022-07529-6

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