Abstract
With the development of optical nanothermometry in biomedical sciences, it is urgent to develop near-infrared region (NIR) nanothermometers which could detect the temperature in deep tissue levels. In this study, NaYF4:Yb,Er@NaGdF4:Nd nanoparticles were successfully synthesized. The luminescence properties and the mechanism of formation of dumbbell morphology of NaYF4:Yb,Er@NaGdF4:Nd were investigated. As a novel optical nanothermometer, dumbbell-shaped NaYF4:Yb,Er@NaGdF4:Nd nanoparticles exhibited high sensitivity in the visible and NIR regions. These data seem to be promising in terms of expanding the optical detection range of non-contact fluorescence temperature sensors and satisfy the requirements for temperature detection in various biological tissues.
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Savchuk O, Carvajal JJ, De la Cruz LG, Haro-González P, Aguiló M, Díaz F (2016) Luminescence thermometry and imaging in the second biological window at high penetration depth with Nd:KGd(WO4) 2 nanoparticles. J Mater Chem C 4:7397–7405
Wawrzynczyk D, Bednarkiewicz A, Nyk M, Strek W, Samoc M (2012) Neodymium(III) doped fluoride nanoparticles as non-contact optical temperature sensors. Nanoscale 4:6959–6961
Carrasco E, del Rosal B, Sanz-Rodríguez F, de la Fuente ÁJ, Gonzalez PH, Rocha U, Kumar KU, Jacinto C, Solé JG, Jaque D (2015) Intratumoral thermal reading during photo-thermal therapy by multifunctional fluorescent nanoparticles. Adv Funct Mater 25:615–626
Wang XD, Wolfbeis OS, Meier RJ (2013) Luminescent probes and sensors for temperature. Chem Soc Rev 42:7834–7869
Shao W, Chen G, Kuzmin A, Kutscher HL, Pliss A, Ohulchanskyy TY, Prasad PN (2016) Tunable narrow band emissions from dye-sensitized core/shell/shell nanocrystals in the second near-infrared biological window. J Am Chem Soc 138:16192–16195
Marciniak L, Prorok K, Frances-Soriano L, Perez-Prieto J, Bednarkiewicz A (2016) A broadening temperature sensitivity range with a core-shell YbEr@YbNd double ratiometric optical nanothermometer. Nanoscale 8:5037–5042
Rai VK (2007) Temperature sensors and optical sensors. Appl Phys B 88:297–303
Cortelletti P, Skripka A, Facciotti C, Pedroni M, Caputo G, Pinna N, Quintanilla M, Benayas A, Vetrone F, Speghini A (2018) Tuning the sensitivity of lanthanide-activated NIR nanothermometers in the biological windows. Nanoscale 10:2568–2576
Ceron EN, Ortgies DH, Del Rosal B, Ren F, Benayas A, Vetrone F, Ma D, Sanz-Rodriguez F, Sole JG, Jaque D, Rodriguez EM (2015) Hybrid nanostructures for high-sensitivity luminescence nanothermometry in the second biological window. Adv Mater 27:4781–4787
del Rosal B, Ximendes E, Rocha U, Jaque D (2017) In vivo luminescence nanothermometry: from materials to applications. Adv Opt Mater 5:1600508–1600521
Kalytchuk S, Polakova K, Wang Y, Froning JP, Cepe K, Rogach AL, Zboril R (2017) Carbon dot nanothermometry: intracellular photoluminescence lifetime thermal sensing. ACS Nano 11:1432–1442
McLaurin EJ, Vlaskin VA, Gamelin DR (2011) Water-soluble dual-emitting nanocrystals for ratiometric optical thermometry. J Am Chem Soc 133:14978–14980
Zhou D, Lin M, Liu X, Li J, Chen Z, Yao D, Sun H, Zhang H, Yang B (2013) Conducting the temperature-dependent conformational change of macrocyclic compounds to the lattice dilation of quantum dots for achieving an ultrasensitive nanothermometer. ACS Nano 7:2273–2283
Hemmer E, Acosta-Mora P, Méndez-Ramos J, Fischer S (2017) Optical nanoprobes for biomedical applications: shining a light on upconverting and near-infrared emitting nanoparticles for imaging, thermal sensing, and photodynamic therapy. J Mater Chem B 5:4365–4392
Wang Z, Zhang P, Yuan Q, Xu X, Lei P, Liu X, Su Y, Dong L, Feng J, Zhang H (2015) Nd(3)(+)-sensitized NaLuF(4) luminescent nanoparticles for multimodal imaging and temperature sensing under 808 nm excitation. Nanoscale 7:17861–17870
Gota C, Uchiyama S, Yoshihara T, Tobita S, Ohwada T (2008) Temperature-dependent fluorescence lifetime of a fluorescent polymeric thermometer, poly(N-isopropylacrylamide), labeled by polarity and hydrogen bonding sensitive 4-sulfamoyl-7-aminobenzofurazan. J Phys Chem B 112:2829–2836
Wu Y, Liu J, Ma J, Liu Y, Wang Y, Wu D (2016) Ratiometric nanothermometer based on rhodamine dye-incorporated F127-melamine-formaldehyde polymer nanoparticle: preparation, characterization, wide-range temperature sensing, and precise intracellular thermometry. ACS Appl Mater Interfaces 8:14396–14405
Wang Z, Hu M, Hu S, Han J, Wang Z, Chen Y, Huang C, Fu L, Zhang Z (2018) Facile one-pot synthesis of multifunctional polyphosphazene nanoparticles as multifunctional platform for tumor imaging. Anal Bioanal Chem 410:3723–3730
Suo H, Guo C, Zheng J, Zhou B, Ma C, Zhao X, Li T, Guo P, Goldys EM (2016) Sensitivity modulation of upconverting thermometry through engineering phonon energy of a matrix. ACS Appl Mater Interfaces 8:30312–30319
Miyagawa T, Fujie T, Ferdinandus, Vo Doan TT, Sato H, Takeoka S (2016) Glue-free stacked luminescent nanosheets enable high-resolution ratiometric temperature mapping in living small animals. ACS Appl Mater Interfaces 8:33377–33385
Kamimura M, Matsumoto T, Suyari S, Umezawa M, Soga K (2017) Ratiometric near-infrared fluorescence nanothermometry in the OTN-NIR (NIR II/III) biological window based on rare-earth doped β-NaYF 4 nanoparticles. J Mater Chem B 5:1917–1925
Wortmann L, Suyari S, Ube T, Kamimura M, Soga K (2018) Tuning the thermal sensitivity of β-NaYF 4: Yb 3+, Ho 3+, Er 3+ nanothermometers for optimal temperature sensing in OTN-NIR (NIR II/III) biological window. J Lumin 198:236–242
Tong L, Li X, Hua R, Cheng L, Sun J, Zhang J, Xu S, Zheng H, Zhang Y, Chen B (2017) Optical temperature sensing properties of Yb 3+/Tm 3+ co-doped NaLuF 4 crystals. Curr Appl Phys 17:999–1004
Li D, Shao Q, Dong Y, Jiang J (2014) Temperature sensitivity and stability of NaYF 4: Yb 3+, Er 3+ core-only and core–shell upconversion nanoparticles. J Alloys Compd 617:1–6
Lu H, Hao H, Shi G, Gao Y, Wang R, Song Y, Wang Y, Zhang X (2016) Optical temperature sensing in β-NaLuF4:Yb3+/Er3+/Tm3+based on thermal, quasi-thermal and non-thermal coupling levels. RSC Adv 6:55307–55311
Zheng K, Song W, He G, Yuan Z, Qin W (2015) Five-photon UV upconversion emissions of Er(3)(+) for temperature sensing. Opt Express 23:7653–7658
Kucsko G, Maurer PC, Yao NY, Kubo M, Noh HJ, Lo PK, Park H, Lukin MD (2013) Nanometre-scale thermometry in a living cell. Nature 500:54–58
Zhaojing B, Min H, Yiming Z, Yiqing W, Jing W, Zhenxi Z (2018) Double NIR laser stimulation and enhancing the thermal sensitivity of Er 3+/Tm 3+/Nd 3+ doped multilayer core–shell nanoparticles. Nanotechnology 29:355704–355712
Zhang Y, Chen B, Xu S, Li X, Zhang J, Sun J, Zheng H, Tong L, Sui G, Zhong H, Xia H, Hua R (2017) Dually functioned core-shell NaYF4:Er3+/Yb3+@NaYF4:Tm3+/Yb3+ nanoparticles as nano-calorifiers and nano-thermometers for advanced photothermal therapy. Sci Rep 7:11849–11860
Zhu X, Feng W, Chang J, Tan YW, Li J, Chen M, Sun Y, Li F (2016) Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature. Nat Commun 7:10437–10446
Yang X, Yang Y, Fu L, Zou M, Li Z, Cao A, Yuan Q (2018) An ultrathin flexible 2D membrane based on single-walled nanotube-MoS2 hybrid film for high-performance solar steam generation. Adv Funct Mater 28:1704505–1704513
Ximendes EC, Rocha U, Sales TO, Fernández N, Sanz-Rodríguez F, Martín IR, Jacinto C, Jaque D (2017) In vivo subcutaneous thermal video recording by supersensitive infrared nanothermometers. Adv Funct Mater 27:1702249–1702257
Yang J, Liu Y, Zhao Y, Gong Z, Zhang M, Yan D, Zhu H, Liu C, Xu C, Zhang H (2017) Ratiometric afterglow nanothermometer for simultaneous in situ bioimaging and local tissue temperature sensing. Chem Mater 29:8119–8131
Dong H, Sun LD, Yan CH (2015) Energy transfer in lanthanide upconversion studies for extended optical applications. Chem Soc Rev 44:1608–1634
Zhang C, Yang L, Zhao J, Liu B, Han MY, Zhang Z (2015) White-light emission from an integrated upconversion nanostructure: toward multicolor displays modulated by laser power. Angew Chem 54:11531–11535
Liu J, Bu W, Zhang S, Chen F, Xing H, Pan L, Zhou L, Peng W, Shi J (2012) Controlled synthesis of uniform and monodisperse upconversion core/mesoporous silica shell nanocomposites for bimodal imaging. Chemistry 18:2335–2341
Park YI, Kim HM, Kim JH, Moon KC, Yoo B, Lee KT, Lee N, Choi Y, Park W, Ling D, Na K, Moon WK, Choi SH, Park HS, Yoon SY, Suh YD, Lee SH, Hyeon T (2012) Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy. Adv Mater 24:5755–5761
Pang X, Wang J, Tan X, Guo F, Lei M, Ma M, Yu M, Tan F, Li N (2016) Dual-modal imaging-guided theranostic nanocarriers based on indocyanine green and mTOR inhibitor rapamycin. ACS Appl Mater Interfaces 8:13819–13829
Xu X, Wang Z, Lei P, Yu Y, Yao S, Song S, Liu X, Su Y, Dong L, Feng J, Zhang H (2015) α-NaYb(Mn)F4:Er3+/Tm3+@NaYF4 UCNPs as “band-shape” luminescent nanothermometers over a wide temperature range. ACS Appl Mater Interfaces 7:20813–20819
Dong H, Sun LD, Feng W, Gu Y, Li F, Yan CH (2017) Versatile spectral and lifetime multiplexing nanoplatform with excitation orthogonalized upconversion luminescence. ACS Nano 11:3289–3297
Chen G, Liu H, Somesfalean G, Liang H, Zhang Z (2009) Upconversion emission tuning from green to red in Yb3+/Ho3+-codoped NaYF4 nanocrystals by tridoping with Ce3+ ions. Nanotechnology 20:385704–385710
Ma D, Xu X, Hu M, Wang J, Zhang Z, Yang J, Meng L (2016) Rare-earth-based nanoparticles with simultaneously enhanced near-infrared (NIR)-visible (Vis) and NIR-NIR dual-conversion luminescence for multimodal imaging. Chem Asian J 11:1050–1058
Ma D, Meng L, Chen Y, Hu M, Chen Y, Huang C, Shang J, Wang R, Guo Y, Yang J (2015) NaGdF4:Yb(3+)/Er(3+)@NaGdF4:Nd(3+)@sodium-gluconate: multifunctional and biocompatible ultrasmall core-shell nanohybrids for UCL/MR/CT multimodal imaging. ACS Appl Mater Interfaces 7:16257–16265
Ximendes EC, Santos WQ, Rocha U, Kagola UK, Sanz-Rodriguez F, Fernandez N, Gouveia-Neto Ada S, Bravo D, Domingo AM, del Rosal B, Brites CD, Carlos LD, Jaque D, Jacinto C (2016) Unveiling in vivo subcutaneous thermal dynamics by infrared luminescent nanothermometers. Nano Lett 16:1695–1703
Tchounwou C, Sinha SS, Viraka Nellore BP, Pramanik A, Kanchanapally R, Jones S, Chavva SR, Ray PC (2015) Hybrid theranostic platform for second near-ir window light triggered selective two-photon imaging and photothermal killing of targeted melanoma cells. ACS Appl Mater Interfaces 7:20649–20656
Plakhotnik T, Gruber D (2010) Luminescence of nitrogen-vacancy centers in nanodiamonds at temperatures between 300 and 700 K: perspectives on nanothermometry. Phys Chem Chem Phys 12:9751–9756
Brites CD, Xie X, Debasu ML, Qin X, Chen R, Huang W, Rocha J, Liu X, Carlos LD (2016) Instantaneous ballistic velocity of suspended Brownian nanocrystals measured by upconversion nanothermometry. Nat Nanotechnol 11:851–856
Liu D, Xu X, Du Y, Qin X, Zhang Y, Ma C, Wen S, Ren W, Goldys EM, Piper JA, Dou S, Liu X, Jin D (2016) Three-dimensional controlled growth of monodisperse sub-50 nm heterogeneous nanocrystals. Nat Commun 7:10254–10261
Sheng Y, Liao L-D, Bandla A, Liu Y-H, Thakor N, Tan MC (2016) Size and shell effects on the photoacoustic and luminescence properties of dual modal rare-earth-doped nanoparticles for infrared photoacoustic imaging. ACS Biomater Sci Eng 2:809–817
Acknowledgements
This work was supported by the National Natural Science Foundation of China (61335012 and 61727823), the Fundamental Funds for the Central Universities and the China Scholarship Council. The TEM was done at International Center for Dielectric Research (ICDR), Xi’an Jiaotong University; the authors thank Mr. Chuansheng Ma and Prof. Guang Yang for their help in using TEM.
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Xu, F., Ba, Z., Zheng, Y. et al. Rare-earth-doped optical nanothermometer in visible and near-infrared regions. J Mater Sci 53, 15107–15117 (2018). https://doi.org/10.1007/s10853-018-2702-9
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DOI: https://doi.org/10.1007/s10853-018-2702-9