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Antioxidant electrospun zein nanofibrous web encapsulating quercetin/cyclodextrin inclusion complex

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Abstract

Quercetin/gamma-cyclodextrin inclusion complex (quercetin/γ-CD-IC)-encapsulated electrospun zein nanofibers were designed as a quick and an efficient antioxidant nanofibrous material via electrospinning. Structural and thermal analyses along with the solubility enhancement as observed in phase-solubility diagram support the successful formation of the inclusion complexation between quercetin and γ-CD. The molar ratio of quercetin and γ-CD was found 1:1 in quercetin/γ-CD-IC which was confirmed with experimental (phase solubility and 1H-NMR) and computational modeling studies. Computational modeling was also useful to indicate that B orientation is more favorable when quercetin is forming host–guest inclusion complexation with γ-CD from the narrow rim. This result was also consistent with the calculations of the experimental studies performed by 1H-NMR. The successful electrospinning of zein nanofiber encapsulating quercetin/γ-CD-IC (zein-quercetin/γ-CD-IC-NF) yielded bead-free nanofiber morphology having 750 ± 255 nm fiber diameter. For comparative studies, pristine zein nanofibers (zein-NF, 695 ± 290 nm) and zein nanofibers encapsulating quercetin only (zein-quercetin-NF, 750 ± 310 nm) were also electrospun. The antioxidant (AO) characteristics of zein-quercetin/γ-CD-IC-NF were studied by the concentration-dependent AO activity tests.

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Acknowledgements

Dr. Uyar acknowledges The Scientific and Technological Research Council of Turkey (TUBITAK)-Turkey (Project # 111M459) for funding this research. Dr. Uyar and Dr. Durgun acknowledge The Turkish Academy of Sciences-Outstanding Young Scientists Award Program (TUBA-GEBIP) for partial funding of the research. Z. Aytac thanks to TUBITAK-BIDEB and TUBITAK (project # 111M459) for the PhD scholarship.

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Authors and Affiliations

  1. Institute of Materials Science and Nanotechnology, UNAM-National Nanotechnology Research Center, Bilkent University, 06800, Ankara, Turkey

    Zeynep Aytac, Engin Durgun & Tamer Uyar

  2. Department of Engineering Physics, Istanbul Medeniyet University, 34700, Istanbul, Turkey

    Semran Ipek

Authors
  1. Zeynep Aytac
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  2. Semran Ipek
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  3. Engin Durgun
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  4. Tamer Uyar
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Correspondence to Tamer Uyar.

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Aytac, Z., Ipek, S., Durgun, E. et al. Antioxidant electrospun zein nanofibrous web encapsulating quercetin/cyclodextrin inclusion complex. J Mater Sci 53, 1527–1539 (2018). https://doi.org/10.1007/s10853-017-1580-x

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  • DOI: https://doi.org/10.1007/s10853-017-1580-x

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