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Polysaccharides/mesoporous silica nanoparticles hybrid composite hydrogel beads for sustained drug delivery

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Abstract

A simple and effective route was established to regulate the drug release kinetics of hydrogels through a combination method of the polysaccharides matrix which delivers the drug and the mesoporous silica nanoparticles (MSN) as a reservoir, making the system release the payload in a controlled manner. The composite MSN beads can construct one kind of novel sustained drug administration device maintaining 24 h activity. With the increase of the MSN ratio in the beads, the sustained-release profile can be increased. The drug release kinetics provide clear evidence that the composite MSN beads delivery systems can protect the model drug of bovine serum albumin from external denaturants and release them slowly in a predictable model. These composite MSN beads with higher drug-loading capacity and better retention ability may facilitate sustained/controlled drug delivery systems for pharmaceutical and biomedical applications.

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Acknowledgements

The authors are grateful to the financial support from the National Natural Science Foundation of China (No. 81401510) and the academic team of South-central University for Nationalities (CZW15017).

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Authors and Affiliations

  1. School of Pharmaceutical Science, South-Central University for Nationalities, Wuhan, 430074, People’s Republic of China

    Yan Hu, Xiaoying Dong, Lei Ke, Shangwen Zhang, Dan Zhao, Han Chen & Xincai Xiao

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  1. Yan Hu
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  2. Xiaoying Dong
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  3. Lei Ke
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  4. Shangwen Zhang
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  5. Dan Zhao
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  7. Xincai Xiao
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Correspondence to Yan Hu.

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Hu, Y., Dong, X., Ke, L. et al. Polysaccharides/mesoporous silica nanoparticles hybrid composite hydrogel beads for sustained drug delivery. J Mater Sci 52, 3095–3109 (2017). https://doi.org/10.1007/s10853-016-0597-x

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  • DOI: https://doi.org/10.1007/s10853-016-0597-x

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