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Accessory pathway location affects brain natriuretic peptide level in patients with Wolff–Parkinson–White syndrome

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Abstract

Purpose

The purpose of this study was to investigate the relationship between the accessory pathway location and brain natriuretic peptide (BNP) level in patients with Wolff–Parkinson–White (WPW) syndrome.

Methods

We divided 102 WPW syndrome patients with normal left ventricular systolic function into four groups: those with manifest right (MR, n = 14), manifest septal (MS, n = 11), manifest left (ML, n = 30), and concealed (C, n = 47) accessory pathways. BNP level and electrophysiological properties, including difference in timing of the ventricular electrogram between the His bundle area and the distal coronary sinus area (His–CS delay), which indicate intraventricular dyssynchrony, were compared.

Results

BNP levels (pg/dl) were higher in the MR and MS groups than in the ML and C groups (MR, 64 ± 58; MS, 55 ± 45; ML, 17 ± 15; C, 25 ± 21; P < 0.001). AV intervals (ms) were shorter in the MR and MS groups than in the ML and C groups (MR, 76 ± 16; MS, 83 ± 6; ML, 101 ± 19; C, 136 ± 20; P < 0.001). His–CS delay (ms) was longer in the MR group than in the other groups (MR, 50 ± 15; MS, 21 ± 7; ML, 23 ± 10; C, 19 ± 8; P < 0.001). The AV interval (P < 0.01) and the His–CS delay (P < 0.001) were negatively and positively correlated, respectively, with the BNP level.

Conclusion

Anterograde conduction with a right or septal accessory pathway increased the BNP level in WPW syndrome patients with normal cardiac function.

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Acknowledgments

This research received no grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Yosuke Nakatani & Koichiro Kinugawa

  2. Division of Cardiology, Gunma Prefectural Cardiovascular Center, Gunma, Japan

    Koji Kumagai, Shigeto Naito, Kohki Nakamura, Kentaro Minami, Masahiro Nakano, Takehito Sasaki & Shigeru Oshima

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  1. Yosuke Nakatani
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  2. Koji Kumagai
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  3. Shigeto Naito
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  4. Kohki Nakamura
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  6. Masahiro Nakano
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  7. Takehito Sasaki
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  9. Shigeru Oshima
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Correspondence to Yosuke Nakatani.

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This study was not funded.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Nakatani, Y., Kumagai, K., Naito, S. et al. Accessory pathway location affects brain natriuretic peptide level in patients with Wolff–Parkinson–White syndrome. J Interv Card Electrophysiol 48, 81–88 (2017). https://doi.org/10.1007/s10840-016-0205-7

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  • DOI: https://doi.org/10.1007/s10840-016-0205-7

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