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Basal characteristics of patients who responded to Ovarian Fragmentation for Follicular Activation (OFFA) or In Vitro Activation (IVA): a systematic review and meta-analysis

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Abstract

A systematic review and meta-analysis were performed to identify if there is a subset of patients with POI who are more likely to show follicular growth after ovarian fragmentation for follicular activation (OFFA) or in vitro activation (IVA). Five studies met inclusion criteria for meta-analysis with a total of 164 patients. Forty-three patients showed follicle development (26.21%). Of those, the pregnancy rate was 35.58% (11/43) and the live birth rate was 20.93% (9/43). Our meta-analysis showed that age was not associated with follicle growth. However, lower baseline FSH, lower duration of amenorrhea/diagnosis, and presence of follicles remaining in biopsy were statistically significant for follicle development. Patients with basal characteristics mentioned before may have more chances to show follicle growth after OFFA or IVA. Taking into account that approximately 20% of patients with follicle growth had live birth, these results are very promising. Given the overall certainty of evidence, future studies are needed to confirm said results.

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Data Availability

The data underlying this article will be shared on reasonable request to the corresponding author.

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Authors and Affiliations

  1. Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo León, Mexico

    Jaime A. Escarcega-Bordagaray, Mauricio Torres-Martinez, David Eugenio Hinojosa-Gonzalez & Mónica Ramírez-Díaz

  2. Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA

    David Eugenio Hinojosa-Gonzalez

  3. Department of Gynecology, Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic of Barcelona, Carrer de Villarroel, 170, 08036, Barcelona, Spain

    Francesc Fàbregues & Francisco Carmona

  4. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Francesc Fàbregues & Francisco Carmona

  5. Faculty of Medicine, University of Barcelona, Barcelona, Spain

    Francesc Fàbregues & Francisco Carmona

Authors
  1. Jaime A. Escarcega-Bordagaray
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  2. Mauricio Torres-Martinez
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  3. David Eugenio Hinojosa-Gonzalez
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  4. Mónica Ramírez-Díaz
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  5. Francesc Fàbregues
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  6. Francisco Carmona
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Contributions

J.A.E.B. conceived the idea of the study. All authors contributed to the study design and protocol development. J.A.E.B. and M.R.D. performed the search. J.A.E.B. and M.R.D. extracted the data. M.T.M and D.E.H.G performed the analysis. J.A.E.B., M.T.M., F.C., and F.F. drafted the manuscript. All authors interpreted the data, critically revised the article, and approved the final version.

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Correspondence to Francesc Fàbregues.

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Escarcega-Bordagaray, J.A., Torres-Martinez, M., Hinojosa-Gonzalez, D.E. et al. Basal characteristics of patients who responded to Ovarian Fragmentation for Follicular Activation (OFFA) or In Vitro Activation (IVA): a systematic review and meta-analysis. J Assist Reprod Genet 41, 989–998 (2024). https://doi.org/10.1007/s10815-024-03046-4

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