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Can cell-free DNA (cfDNA) testing alleviate psychological distress in early miscarriage? A commentary

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Abstract

Background

Psychological, emotional, and mental distress affects many patients who experience early pregnancy loss (EPL). A common concern is that the patient’s actions or choices caused the loss. Understanding the cause of EPL may improve the distress of EPL patients and their partners. Chromosomal abnormalities leading to a significant portion of EPL. Cell-free DNA (cfDNA) testing, a non-invasive test providing high quality information about the chromosomal makeup of a fetus, may offer assurance that a fetal abnormality caused the loss, and provide more certainty or closure in processing EPL. CfDNA may be a useful adjunct to patient-centered care in the setting of EPL. This commentary explores the possibility of cfDNA testing in lessening the emotional distress that often accompanies EPL.

Methods

The peer reviewed literature was explored for manuscripts addressing (1) the potential for cfDNA serum testing for patients experiencing EPL and screening products of conception to determine the cause of EPL; and/or (2) the impact that information might have on the psychological morbidity of EPL for patients and their partners. Themes generated from extracted data were used to generate key questions for future research.

Results

Preliminary findings suggest fetal fraction values are instrumental in the success of cfDNA testing, and a successful cfDNA testing experience can have a positive impact on patients.

Conclusions

Ultimately, we conclude cfDNA testing could have a positive impact in patient care and improve the well-being of patients undergoing the emotional toll of EPL by reducing feelings of guilt and providing closure to those who learn the loss was associated with chromosomal abnormality. Further trials and studies that explore the intersection of mental health of EPL on patients should explore the efficacy of cfDNA testing as an adjunct to patient-centered care in these cases.

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Authors and Affiliations

  1. Department of Biomolecular Science, New York University Tandon School of Engineering, New York, NY, USA

    Shadin Zayyad

  2. Department of Biology and School of Global Public Health, New York University School of Arts and Sciences, New York, NY, USA

    Renee Liang

  3. Department of OB-GYN, Grossman School of Medicine, New York University, 550 First Avenue NBV 9N1-F, New York, NY, 10016, USA

    Abigail Ford Winkel, David L. Keefe & Gwendolyn P. Quinn

Authors
  1. Shadin Zayyad
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  2. Renee Liang
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  3. Abigail Ford Winkel
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  4. David L. Keefe
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  5. Gwendolyn P. Quinn
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Correspondence to Gwendolyn P. Quinn.

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Zayyad, S., Liang, R., Winkel, A.F. et al. Can cell-free DNA (cfDNA) testing alleviate psychological distress in early miscarriage? A commentary. J Assist Reprod Genet 39, 1219–1224 (2022). https://doi.org/10.1007/s10815-022-02489-x

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  • DOI: https://doi.org/10.1007/s10815-022-02489-x

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