The effectiveness of phototherapy for hyperbilirubinemia of newborns using narrowband LED sources was found to depend not only on the position of the LED emission spectrum peak within the absorption band of bilirubin but also on the width of the incident radiation spectrum. Extension of the spectral range of radiation by adding a green component with λmax ≈ 505 nm to the blue light band with λmax ≈ 462 nm (provided equal integrated power density) gives a more efficient decrease in the total bilirubin level in the blood of newborns. This effect was attributed to heterogeneity of the spectral characteristics of bilirubin in different microenvironments as well as dependence of the optimal wavelength for photoisomerization of the pigment on the depth of the blood vessels where the bilirubin phototransformation reactions occur. Moreover, extension of the spectral range of the incident radiation by adding a green component increases the irradiated volumes of blood where the photoisomerization reactions with a high lumirubin quantum yield underlying this phototherapy are initiated.
Similar content being viewed by others
References
American Academy of Pediatrics. Subcommittee on Hyperbilirubinemia, Pediatrics, 114, No. 1, 297–316 (2004).
J. F. Watchko, Res. Rep. Neonatol., 4, 183–193 (2014).
M. J. Maisels, J. F. Watchko, V. K. Bhutani, and D. K. Stevenson, J. Perinatol., 32, No. 9, 660–664 (2012).
V. Yu. Plavskii, in: J. F. Novotny and F. Sedlacek (Eds.), Bilirubin: Chemistry, Regulation and Disorder, Nova Science Publishers, New York (2012), pp. 1–65.
T. Xiong, Y. Qu, S. Cambier, and D. Mu, Eur. J. Pediatr., 170, No. 10, 1247–1255 (2011).
M. J. Maisels and A. F. McDonagh, N. Engl. J. Med., 358, No. 9, 920–928 (2008).
V. K. Bhutani, Pediatrics, 128, No. 4, 1046–1052 (2011).
V. Yu. Plavskii, Biomed. Eng., 47, No. 2, 91–95 (2013).
V. Yu. Plavskii, A. I. Tret’yakova, and G. R. Mostovnikova, J. Opt. Technol., 81, No. 6, 341–348 (2014).
D. A. Lightner and A. F. McDonagh, Acc. Chem. Res., 17, No. 12, 417–424 (1984).
V. Yu. Plavskii, V. N. Knukshto, A. S. Stasheuski, A. I. Tret’yakova, A. V. Mikulich, L. G. Plavskaya, I. A. Leusenko, and B. M. Dzhagarov, Abstracts of the 37th Meeting of the American Society of Photobiology, San Diego, California, June 14–19, 2014 (2014), p. 82.
K. L. Tan, J. Pediatr., 114, No. 1, 132–137 (1989).
C. Vecchi, G. P. Donzelli, and M. G. Migliorini, Pediatr. Res., 17, No. 6, 4461–463 (1983).
C. Vecchi, G. P. Donzelli, G. Sbrana, and R. Pratesi, J. Pediatr., 108, No. 3, 452–456 (1986).
H. Ayyash, E. Hadjigeorgiou, J. Sofatzis, A. Chatziioannou, D. Nicolopoulos, and E. Sideris, Pediatrics, 111, No. 6, 882–887 (1987).
H. Ayyash, E. Hadjigeorgiou, J. Sofatzis, H. Dellagrammaticas, and E. Sideris, Arch. Dis. Child., 62, No. 8, 843–845 (1987).
M. Amato and D. Inaebnit, Eur. J. Pediatr., 150, No. 4, 274–276 (1991).
G. P. Donzelli, S. Pratesi, G. Rapisardi, G. Agati, F. Fusi, and R. Pratesi, Lancet, 346, No. 8968, 184–185 (1995).
F. Ebbesen, G. Agati, and R. Pratesi, Arch. Dis. Child. Fetal. Neonatal. Ed., 88, No. 5, 430–431 (2003).
F. Ebbesen, P. Madsen, S. Støvring, H. Hundborg, and G. Agati, Acta Paediatr., 96, No. 6, 837–841 (2007).
A. F. McDonagh, G. Agati, F. Fusi, and R. Pratesi, Photochem. Photobiol., 50, No. 3, 305–319 (1989).
S. Onishi, S. Itoh, and K. Isobe, Biochem. J., 236, No. 1, 23–29 (1986).
V. Yu. Plavskii, V. A. Mostovnikov, G. R. Mostovnikova, and A. I. Tret’yakova, Zh. Prikl. Spektroskopii, 74, No. 1, 108–119 (2007) [J. Appl. Spectroscopy, 74, No. 1, 120–132 (2007)].
V. Yu. Plavskii, V. A. Mostovnikov, A. I. Tret’yakova, and G. R. Mostovnikova, J. Opt. Technol., 74, No. 7, 446–454 (2007).
A. A. Lamola, V. K. Bhutani, R. J. Wong, D. K. Stevenson, and A. F. McDonagh, Pediatr. Res., 74, No. 1, 54–60 (2013).
A. A. Lamola and M. Russo, Photochem. Photobiol., 90, No. 2, 294–296 (2014).
R. Pratesi, L. Ronchi, G. Cecchi, G. Sbrana, M. G. Migliorini, C. Vecchi, and G. Donzelli, Photochem. Photobiol, 40, No. 1, 77–83 (1984).
S. A. Lysenko and M. M. Kugeiko, Zh. Prikl. Spektrosk., 81, No. 5, 761–769 (2014).
G. Agati, F. Fusi, G. P. Donzelli, and R. Pratesi, J. Photochem. Photobiol., B: Biol., 18, Nos. 2–3, 197–203 (1993).
D. S. Seidman, J. Moise, Z. Ergaz, A. Laor, H. J. Vreman, D. K. Stevenson, and R. Gale, J. Perinatol., 23, No. 2, 123–127 (2003).
F. Ebbesen, P. K. Vandborg, P. H. Madsen, T. Trydal, L. H. Jakobsen, and H. J. Vreman, Pediatr. Res., 79, No. 2, 308–312 (2016).
T. Hegyi, M. Graff, V. Zapanta, I. M. Hiatt, and T. R. Sisson, Am. J. Dis. Child., 140, No. 10, 994–997 (1986).
G. R. Mostovnikova, V. A. Mostovnikov, V. Yu. Plavskii, A. I. Tret’yakova, S. P. Andreev, and A. B. Ryabtsev, Opt. Zh., 67, No. 11, 60–63 (2000).
Y. Uchida, Y. Morimoto, J. Haku, T. Nakagawa, T. Nishikubo, and Y. Takahashi, J. Japan. Soc. Premature Newborn Med., 23, No. 2, 263–267 (2011).
Y. Uchida, Y. Morimoto, T. Uchiike, T. Kamamoto, T. Hayashi, I. Arai, T. Nishikubo, and Y. Takahashi, Early Hum. Dev., 91, No. 7, 381–385 (2015).
S. Pratesi, S. Di Fabio, C. Bresci, C. Di Natale, S. Bar, and C. Dani, Am. J. Perinatol., 32, No. 8, 779–784 (2015).
G. Hart and R. Cameron, Arch. Dis. Child. Fetal Neonatal Ed., 90, No. 5, F437i–F440 (2005).
H. J. Vreman, R. J. Wong, J. R. Murdock, and D. K. Stevenson, Acta Paediatrica, 97, No. 3, 308–316 (2008).
S. D. P. Wentworth, Infant, 1, No. 1, 14–19 (2005).
K. L. Tan, Pediatr. Res., 16, No. 8, 670–674 (1982).
T. R. C. Sisson, N. Kendall, E. Shaw, and L. KechavarzOliai, J. Pediatr., 81, No. 1, 35–38 (1972).
N. Modi and A. J. Keay, Arch. Dis. Child., 58, No. 6, 406–409 (1983).
L. C. Mims, M. Estrada, D. S. Gooden, R. R. Caldwell, and R. V. Kotas, J. Pediatr., 83, No. 4, 658–662 (1972).
P. K. Vandborg, B. M. Hansen, G. Greisen, and F. Ebbesen, Pediatrics, 130, No. 2, 352–357 (2012).
Q. Peng, A. Juzeniene, J. Chen, L. O. Svaasand, T. Warloe, K.-E. Giercksky, and J. Moan, Rep. Prog. Phys., 71, No. 5, 056701–056728 (2008).
A. N. Bashkatov, E. A. Genina, V. I. Kochubei (Kochubey), and V. V. Tuchin, J. Phys. D: Appl. Phys., 38, No. 15, 2543–2555 (2005).
S. Onishi, S. Itoh, K. Isobe, M. Ochi, T. Kunikata, and T. Imai, Biochem. J., 257, No. 3, 711–714 (1989).
A. A. Spector, J. Lipid Res., 16, No. 3, 165–179 (1975).
A. Robertson, S. Fink, and W. Karp, J. Pediatr., 112, No. 2, 291–294 (1988).
P. Novotná and M. Urbanová, Biochim. Biophys. Acta, 1848, No. 6, 1331–1340 (2015).
V. Malhotra, J. W. Greenberg, L. L. Dunn, and J. F. Ennever, Pediatr. Res., 21, No. 6, 530–533 (1987).
N. Usharani, G. C. Jayakumar, J. R. Rao, B. Chandrasekaran, and B. U. Nair, J. Microsc., 253, No. 2, 109–118 (2014).
F. Zsila, Biomacromolecules, 12, No. 1, 221–227 (2011).
V. Yu. Plavskii, V. A. Mostovnikov, A. I. Tret’yakova, and G. R. Mostovnikova, J. Appl. Spectroscopy, 75, No. 3, 407–419 (2008).
A. T. Costarino, J. F. Ennever, S. Baumgart, W. T. Speck, M. Paul, and R. A. Polin, Pediatrics, 75, No. 3, 519–522 (1985).
K. Mreihil, P. Madsen, B. Nakstad, J. Š. Benth, F. Ebbesen, and T. W. Hansen, Pediatr. Res., 78, No. 1, 56–62 (2015).
R. Pratesi, G. Agati, and F. Fusi, Photochem. Photobiol., 40, No. 1, 41–47 (1984).
P. Novotná, I. Goncharova, and M. Urbanová, Biochim. Biophys. Acta, 1838, 831–841 (2014).
P. Novotná, F. Králik, and M. Urbanová, Biophys. Chem., 205, 41–50 (2015).
O. A. Kozlenkova, L. G. Plavskaya, A. V. Mikulich, I. A. Leusenko, A. I. Tret′yakova, and V. Yu. Plavskii, Izv. Nats. Akad. Nauk Belarusi, Ser. Fiz. Mat. Nauk, No. 1, 117–123 (2016).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 84, No. 1, pp. 106–119, January–February, 2017.
Rights and permissions
About this article
Cite this article
Plavskii, V.Y., Mikulich, A.V., Leusenko, I.A. et al. Spectral Range Optimization to Enhance the Effectiveness of Phototherapy for Neonatal Hyperbilirubinemia. J Appl Spectrosc 84, 92–102 (2017). https://doi.org/10.1007/s10812-017-0433-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10812-017-0433-3