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Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach

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Abstract

The objective of this review is to consider the psychological (largely behavioral) and biological [neurochemical, medical (including genetic), and pharmacological] theories and approaches that contribute to current thinking about the etiology and treatment of self-injurious behavior (SIB) in individuals with autism spectrum disorder and/or intellectual disability. Algorithms for the assessment and treatment of SIB in this context, respectively, from a multidisciplinary, integrative perspective are proposed and challenges and opportunities that exist in clinical and research settings are discussed.

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References

  • Aboitiz, F., Scheibel, A. B., Fisher, R. S., & Zaidel, E. (1992). Individual differences in brain asymmetries and fiber composition in the human corpus callosum. Brain Research, 598(1), 154–161.

    PubMed  Google Scholar 

  • Adamson, W. C., Nellis, B. P., Runge, G., Cleland, C., & Killian, E. (1958). Use of tranquilizers for mentally deficient patients. Archives of Pediatrics and Adolescent Medicine, 96(2), 159–164.

    Google Scholar 

  • Aghajanian, G. K., & Sanders-Bush, E. (2002). Serotonin. In K. L. Davis, D. Charney, J. T. Coyle, & C. Nemeroff (Eds.), Neuropsychopharmacology: The fifth generation of progress (pp. 15–34). Philidelphia, PA: Lippincott Williams & Wilkins.

    Google Scholar 

  • Alexander, A. L., Lee, J. E., Lazar, M., Boudos, R., DuBray, M. B., Oakes, T. R., et al. (2007). Diffusion tensor imaging of the corpus callosum in autism. Neuroimage, 34(1), 61–73.

    PubMed  Google Scholar 

  • Aman, M. G. (1993). Efficacy of psychotropic drugs for reducing self-injurious behavior in the developmental disabilities. Annals of Clinical Psychiatry, 5(3), 171–188.

    PubMed  Google Scholar 

  • Aman, M. G., De Smedt, G., Derivan, A., Lyons, B., & Findling, R. L. (2002). Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence. The American Journal of Psychiatry, 159(8), 1337–1346.

    PubMed  Google Scholar 

  • Aman, M. G., Kasper, W., Manos, G., Mathew, S., Marcus, R., Owen, R., et al. (2010). Line-item analysis of the Aberrant Behavior Checklist: Results from two studies of aripiprazole in the treatment of irritability associated with autistic disorder. Journal of Child and Adolescent Psychopharmacology, 20(5), 415–422.

    PubMed  Google Scholar 

  • Aman, M. G., & Madrid, A. (1999). Atypical antipsychotics in persons with developmental disabilities. Mental Retardation and Developmental Disabilities Research Reviews, 5(4), 253–263.

    Google Scholar 

  • Aman, M. G., McDougle, C. J., Scahill, L., Handen, B., Arnold, L. E., Johnson, C., et al. (2009). Medication and parent training in children with pervasive developmental disorders and serious behavior problems: Results from a randomized clinical trial. Journal of the American Academy of Child and Adolescent Psychiatry, 48(12), 1143–1154.

    PubMed  Google Scholar 

  • Aman, M. G., Teehan, C. J., White, A. J., Turbott, S. H., & Vaithianathan, C. (1989). Haloperidol treatment with chronically medicated residents: Dose effects on clinical behavior and reinforcement contingencies. American Journal of Mental Retardation, 93(4), 452–460.

    PubMed  Google Scholar 

  • Aman, M. G., & White, A. J. (1988). Thioridazine dose effects with reference to stereotypic behavior in mentally retarded residents. Journal of Autism and Developmental Disorders, 18(3), 355–366.

    PubMed  Google Scholar 

  • Anderson, L. T., & Ernst, M. (1994). Self-injury in Lesch-Nyhan disease. Journal of Autism and Developmental Disorders, 24(1), 67–81.

    PubMed  Google Scholar 

  • Anderson, G. M., Gutknecht, L., Cohen, D. J., Brailly-Tabard, S., Cohen, J. H., Ferrari, P., et al. (2002). Serotonin transporter promoter variants in autism: Functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry, 7(8), 831–836.

    PubMed  Google Scholar 

  • Anderson, L. T., Herrmann, L., & Dancis, J. (1976). The effect of L-5-hydroxytryptophan on self-mutilation in Lesch-Nyhan disease: A negative report. Neuropadiatrie, 7(4), 439–442.

    PubMed  Google Scholar 

  • Arnold, L. E., Vitiello, B., McDougle, C. J., Scahill, L., Shah, B., Gonzales, N. M., et al. (2003). Parent-defined target symptoms respond to risperidone in RUPP autism study: Customer approach to clinical trials. Journal of the American Academy of Child and Adolescent Psychiatry, 42(12), 1443–1450.

    PubMed  Google Scholar 

  • Arron, K., Oliver, C., Moss, J., Berg, K., & Burbidge, C. (2011). The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes. Journal of Intellectual Disability Research, 55(2), 109–120.

    PubMed  Google Scholar 

  • Baghdadli, A., Pascal, C., Grisi, S., & Aussilloux, C. (2003). Risk factors for self-injurious behaviours among 222 young children with autistic disorders. Journal of Intellectual Disability Research, 47(8), 622–627.

    PubMed  Google Scholar 

  • Baghdadli, A., Picot, M. C., Pry, R., Michelon, C., Burzstejn, C., Lazartigues, A., et al. (2008). What factors are related to a negative outcome of self-injurious behaviour during childhood in pervasive developmental disorders? Journal of Applied Research in Intellectual Disabilities, 21(2), 142–149.

    Google Scholar 

  • Baldessarini, R. J., & Frankenburg, F. R. (1991). Clozapine: A novel antipsychotic agent. The New England Journal of Medicine, 324(11), 746–754.

    PubMed  Google Scholar 

  • Barrera, F. J., Violo, R. A., & Graver, E. E. (2007). On the form and function of severe self-injurious behavior. Behavioral Interventions, 22(1), 5–33.

    Google Scholar 

  • Baumeister, A. A., & Frye, G. D. (1984). Self-injurious behavior in rats produced by intranigral microinjection of GABA agonists. Pharmacology, Biochemistry and Behavior, 21(1), 89–95.

    PubMed  Google Scholar 

  • Baumeister, A. A., & Frye, G. D. (1985). The biochemical basis of the behavioral disorder in the Lesch-Nyhan syndrome. Neuroscience and Biobehavioral Reviews, 9(2), 169–178.

    PubMed  Google Scholar 

  • Baxter, C., Cummins, R. A., & Yiolitis, L. (2000). Parental stress attributed to family members with and without intellectual disability: A longitudinal study. Journal of Intellectual and Developmental Disability, 25(2), 105–118.

    Google Scholar 

  • Beadle-Brown, J., Murphy, G., & Wing, L. (2005). Long-term outcome for people with severe intellectual disabilities: Impact of social impairment. American Journal of Mental Retardation, 110(1), 1–12.

    PubMed  Google Scholar 

  • Bear, D., Levin, K., Blumer, D., Chetham, D., & Ryder, J. (1982). Interictal behaviour in hospitalised temporal lobe epileptics: Relationship to idiopathic psychiatric syndromes. Journal of Neurology, Neurosurgery and Psychiatry, 45(6), 481–488.

    PubMed Central  PubMed  Google Scholar 

  • Bitsika, V., & Sharpley, C. F. (2004). Stress, anxiety and depression among parents of children with autism spectrum disorder. Australian Journal of Guidance and Counselling, 14(2), 151–161.

    Google Scholar 

  • Blacher, J., Lopez, S., Shapiro, J., & Fusco, J. (1997). Contributions to depression in latina mothers with and without children with retardation: Implications for caregiving. Family Relations, 46(4), 325–334.

    Google Scholar 

  • Blake, B. L., Muehlmann, A. M., Egami, K., Breese, G. R., Devine, D. P., & Jinnah, H. A. (2007). Nifedipine suppresses self-injurious behaviors in animals. Developmental Neuroscience, 29(3), 241–250.

    PubMed Central  PubMed  Google Scholar 

  • Blatt, G. J. (2011). The GABA system in autism. In E. Hollander, A. Kolevzon, & J. T. Coyle (Eds.), Textbook of autism spectrum disorders (pp. 323–326). Washington, DC: American Psychiatric Publishing Inc.

    Google Scholar 

  • Blatt, G. J., Fitzgerald, C. M., Guptill, J. T., Booker, A. B., Kemper, T. L., & Bauman, M. L. (2001). Density and distribution of hippocampal neurotransmitter receptors in autism: An autoradiographic study. Journal of Autism and Developmental Disorders, 31(6), 537–543.

    PubMed  Google Scholar 

  • Bloch, M. R., Elliott, M., Thompson, H., & Koran, L. M. (2001). Fluoxetine in pathologic skin-picking: Open-label and double-blind results. Psychosomatics, 42(4), 314–319.

    PubMed  Google Scholar 

  • Blumer, D. (2000). Dysphoric disorders and paroxysmal affects: Recognition and treatment of epilepsy-related psychiatric disorders. Harvard Review of Psychiatry, 8(1), 8–17.

    PubMed  Google Scholar 

  • Borrero, J. C., Vollmer, T. R., Wright, C. S., Lerman, D. C., & Kelley, M. E. (2002). Further evaluation of the role of protective equipment in the functional analysis of self-injurious behavior. Journal of Applied Behavior Analysis, 35(1), 69–72.

    PubMed Central  PubMed  Google Scholar 

  • Bosch, J., Van Dyke, C., Smith, S. M., & Poulton, S. (1997). Role of medical conditions in the exacerbation of self-injurious behavior: An exploratory study. Mental Retardation, 35(2), 124–130.

    PubMed  Google Scholar 

  • Boyer, W. F., & Feighner, J. P. (1992). An overview of paroxetine. The Journal of Clinical Psychiatry, 53, 3–6.

    PubMed  Google Scholar 

  • Brahm, N. C., Fast, G. A., & Brown, R. C. (2008). Buspirone for autistic disorder in a woman with an intellectual disability. The Annals of Pharmacotherapy, 42(1), 131–137.

    PubMed  Google Scholar 

  • Brandt, B. R., & Rosen, I. (1998). Impaired peripheral somatosensory function in children with Prader-Willi syndrome. Neuropediatrics, 29(3), 124–126.

    PubMed  Google Scholar 

  • Breau, L. M., Camfield, C. S., Symons, F. J., Bodfish, J. W., Mackay, A., Finley, G. A., et al. (2003). Relation between pain and self-injurious behavior in nonverbal children with severe cognitive impairments. The Journal of Pediatrics, 142(5), 498–503.

    PubMed  Google Scholar 

  • Breau, L. M., McGrath, P. J., Camfield, C., Rosmus, C., & Finley, G. A. (2000). Preliminary validation of an observational pain checklist for persons with cognitive impairments and inability to communicate verbally. Developmental Medicine and Child Neurology, 42(9), 609–616.

    PubMed  Google Scholar 

  • Breese, G. R., Baumeister, A. A., McCown, T. J., Emerick, S. G., Frye, G. D., Crotty, K., et al. (1984). Behavioral differences between neonatal and adult 6-hydroxydopamine-treated rats to dopamine agonists: Relevance to neurological symptoms in clinical syndromes with reduced brain dopamine. The Journal of Pharmacology and Experimental Therapeutics, 231(2), 343–354.

    PubMed Central  PubMed  Google Scholar 

  • Breese, G. R., Criswell, H. E., Duncan, G. E., & Mueller, R. A. (1990). A dopamine deficiency model of Lesch-Nyhan disease: The neonatal-6-OHDA-lesioned rat. Brain Research Bulletin, 25(3), 477–484.

    PubMed  Google Scholar 

  • Bruhl, H. H., Fielding, L., Joyce, M., Peters, W., & Wieseler, N. (1982). Thirty-month demonstration project for treatment of self-injurious behavior in severely retarded individuals. Monographs of the American Association on Mental Deficiency, 5, 191–275.

    PubMed  Google Scholar 

  • Brylewski, J., & Wiggs, L. (1999). Sleep problems and daytime challenging behaviour in a community-based sample of adults with intellectual disability. Journal of Intellectual Disability Research, 43(6), 504–512.

    PubMed  Google Scholar 

  • Buitelaar, J. K. (1993). Self-injurious behaviour in retarded children: Clinical phenomena and biological mechanisms. Acta Paedopsychiatrica, 56(2), 105–111.

    PubMed  Google Scholar 

  • Butler, M. G., Bittel, D. C., Kibiryeva, N., Talebizadeh, Z., & Thompson, T. (2004). Behavioral differences among subjects with Prader-Willi syndrome and type I or type II deletion and maternal disomy. Pediatrics, 113(3), 565–573.

    PubMed  Google Scholar 

  • Campbell, M., Anderson, L. T., Small, A. M., Adams, P., Gonzalez, N. M., & Ernst, M. (1993). Naltrexone in autistic children: Behavioral symptoms and attentional learning. Journal of the American Academy of Child and Adolescent Psychiatry, 32(6), 1283–1291.

    PubMed  Google Scholar 

  • Cancela, L. M., Artinian, J., & Fulginiti, S. (1988). Opioid influence on some aspects of stereotyped behavior induced by repeated amphetamine treatment. Pharmacology, Biochemistry and Behavior, 30(4), 899–904.

    PubMed  Google Scholar 

  • Canitano, R. (2006). Self injurious behavior in autism: Clinical aspects and treatment with risperidone. Journal of Neural Transmission, 113(3), 425–431.

    PubMed  Google Scholar 

  • Carr, J. E., Coriaty, S., Wilder, D. A., Gaunt, B. T., Dozier, C. L., Britton, L. N., et al. (2000). A review of “noncontingent” reinforcement as treatment for the aberrant behavior of individuals with developmental disabilities. Research in Developmental Disabilities, 21(5), 377–391.

    PubMed  Google Scholar 

  • Carr, E. G., & LeBlanc, L. A. (2003). Functional analysis of problem behavior. In W. Donahue, J. E. Fishers, & S. C. Hayes (Eds.), Cognitive behavior therapy: Applying empirically supported techniques in your practice. Hoboken, NJ: Wiley.

    Google Scholar 

  • Carr, J. E., Severtson, J. M., & Lepper, T. L. (2009). Noncontingent reinforcement is an empirically supported treatment for problem behavior exhibited by individuals with developmental disabilities. Research in Developmental Disabilities, 30(1), 44–57.

    PubMed  Google Scholar 

  • Carr, E. G., & Smith, C. E. (1995). Biological setting events for self-injury. Mental Retardation and Developmental Disabilities Research Reviews, 1(2), 94–98.

    Google Scholar 

  • Carr, E. G., Smith, C. E., Giacin, T. A., Whelan, B. M., & Pancari, J. (2003). Menstrual discomfort as a biological setting event for severe problem behavior: Assessment and intervention. American Journal of Mental Retardation, 108(2), 117–133.

    PubMed  Google Scholar 

  • Carroll, M. N., & Lim, R. K. (1960). Observations on the neuropharmacology of morphine and morphinelike analgesia. Archives Internationales de Pharmacodynamie et de Therapie, 125, 383–403.

    PubMed  Google Scholar 

  • Cassidy, S. B. (1997). Prader-Willi syndrome. Journal of Medical Genetics, 34(11), 917–923.

    PubMed Central  PubMed  Google Scholar 

  • Cassidy, S. B., & Driscoll, D. J. (2009). Prader-Willi syndrome. European Journal of Human Genetics, 17(1), 3–13.

    PubMed Central  PubMed  Google Scholar 

  • Cassidy, S. B., Schwartz, S., Miller, J. L., & Driscoll, D. J. (2012). Prader-Willi syndrome. Genetics in Medicine, 14(1), 10–26.

    PubMed  Google Scholar 

  • Clarke, S., Dunlap, G., & Vaughn, B. (1999). Family-centered, assessment-based intervention to improve behavior during an early morning routine. Journal of Positive Behavior Interventions, 1(4), 235–241.

    Google Scholar 

  • Codling, M., & MacDonald, N. (2009). Epilepsy: Implications for people with profound intellectual and multiple disabilities. In J. Pawlyn & S. Carnaby (Eds.), Profound intellectual and multiple disabilities: Nursing complex needs (pp. 134–146). Hoboken: Wiley.

    Google Scholar 

  • Coffey, M. J. (2013). Resolution of self-injury with phenytoin in a man with autism and intellectual disability: The role of frontal lobe seizures and catatonia. Journal of ECT, 29(1), 12–13.

    Google Scholar 

  • Cohen, S. A., & Underwood, M. T. (1994). The use of clozapine in a mentally retarded and aggressive population. Journal of Clinical Psychiatry, 55(10), 440–444.

    PubMed  Google Scholar 

  • Collins, M. S., & Cornish, K. (2002). A survey of the prevalence of stereotypy, self-injury and aggression in children and young adults with Cri du Chat syndrome. Journal of Intellectual Disability Research, 46(2), 133–140.

    PubMed  Google Scholar 

  • Consoli, A., Cohen, J., Bodeau, N., Guinchat, V., Wachtel, L., & Cohen, D. (2013). Electroconvulsive therapy in adolescents with intellectual disability and severe self-injurious behavior and aggression: A retrospective study. European Child and Adolescent Psychiatry, 22(1), 55–62.

    PubMed  Google Scholar 

  • Conti, F., & Manzoni, T. (1994). The neurotransmitters and postsynaptic actions of callosally projecting neurons. Behavioural Brain Research, 64(1), 37–53.

    PubMed  Google Scholar 

  • Cooper, A. F., & Fowlie, H. C. (1973). Control of gross self-mutilation with lithium carbonate. The British Journal of Psychiatry, 122(568), 370–371.

    PubMed  Google Scholar 

  • Cooper, J. O., Heron, T. E., & Heward, W. L. (2007). Applied behavior analysis. New Jersey: Pearson Education Inc.

    Google Scholar 

  • Cooper, S. A., Smiley, E., Allan, L. M., Jackson, A., Finlayson, J., Mantry, D., et al. (2009). Adults with intellectual disabilities: Prevalence, incidence and remission of self-injurious behaviour, and related factors. Journal of Intellectual Disability Research, 53(3), 200–216.

    PubMed  Google Scholar 

  • Cornish, K. M., Bramble, D., Munir, F., & Pigram, J. (1999). Cognitive functioning in children with typical cri du chat (5p-) syndrome. Developmental Medicine and Child Neurology, 41(4), 263–266.

    PubMed  Google Scholar 

  • Courtemanche, A., Schroeder, S., Sheldon, J., Sherman, J., & Fowler, A. (2012). Observing signs of pain in relation to self-injurious behaviour among individuals with intellectual and developmental disabilities. Journal of Intellectual Disability Research, 56(5), 501–515.

    PubMed  Google Scholar 

  • Crawford, H. (2009). Dysphagia and people with profound intellectual and multiple disabilities. In J. Pawlyn & S. Carnaby (Eds.), Profound intellectual and multiple disabilities: Nursing complex needs (pp. 236–258). Hoboken: Wiley.

    Google Scholar 

  • Crockett, C. M., Sackett, G. P., Sandman, C. A., Chicz-DeMet, A., & Bentson, K. L. (2007). Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sex. Peptides, 28(10), 1987–1997.

    PubMed Central  PubMed  Google Scholar 

  • Crossland, S., Burns, M., Leach, C., & Quinn, P. (2005). Needs assessment in forensic learning disability. Medicine, Science and the Law, 45(2), 147–153.

    Google Scholar 

  • Czapinski, P., Blaszczyk, B., & Czuczwar, S. J. (2005). Mechanisms of action of antiepileptic drugs. Current Topics in Medicinal Chemistry, 5(1), 3–14.

    PubMed  Google Scholar 

  • Davanzo, P. A., Belin, T. R., Widawski, M. H., & King, B. H. (1998). Paroxetine treatment of aggression and self-injury in persons with mental retardation. American Journal of Mental Retardation, 102(5), 427–437.

    PubMed  Google Scholar 

  • Davanzo, P. A., & King, B. H. (1996). Open trial lamotrigine in the treatment of self-injurious behavior in an adolescent with profound mental retardation. Journal of Child and Adolescent Psychopharmacology, 6(4), 273–279.

    PubMed  Google Scholar 

  • Davis, K. V., Sprague, R. L., & Werry, J. S. (1969). Stereotyped behavior and activity level in severe retardates: The effect of drugs. American Journal of Mental Deficiency, 73(5), 721–727.

    PubMed  Google Scholar 

  • de Winter, C. F., Jansen, A. A., & Evenhuis, H. M. (2011). Physical conditions and challenging behaviour in people with intellectual disability: A systematic review. Journal of Intellectual Disability Research, 55(7), 675–698.

    PubMed  Google Scholar 

  • Deb, S., Thomas, M., & Bright, C. (2001). Mental disorder in adults with intellectual disability. 2: The rate of behaviour disorders among a community-based population aged between 16 and 64 years. Journal of Intellectual Disability Research, 45(6), 506–514.

    PubMed  Google Scholar 

  • DeLeon, I. G., Fisher, W. W., & Marhefka, J. M. (2004). Decreasing self-injurious behavior associated with awakening in a child with autism and developmental delays. Behavioral Interventions, 19(2), 111–119.

    Google Scholar 

  • Didden, R., Korzilius, H., & Curfs, L. M. (2007). Skin-picking in individuals with Prader-Willi syndrome: Prevalence, functional assessment, and its comorbidity with compulsive and self-injurious behaviours. Journal of Applied Research in Intellectual Disabilities, 20(5), 409–419.

    Google Scholar 

  • Dooley, P., Wilczenski, F. L., & Torem, C. (2001). Using an activity schedule to smooth school transitions. Journal of Positive Behavior Interventions, 3(1), 57–61.

    Google Scholar 

  • Dove, D., Warren, Z., McPheeters, M. L., Taylor, J. L., Sathe, N. A., & Veenstra-VanderWeele, J. (2012). Medications for adolescents and young adults with autism spectrum disorders: A systematic review. Pediatrics, 130(4), 717–726.

    PubMed Central  PubMed  Google Scholar 

  • Duerden, E. G., Oatley, H. K., Mak-Fan, K. M., McGrath, P. A., Taylor, M. J., Szatmari, P., et al. (2012). Risk factors associated with self-injurious behaviors in children and adolescents with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(11), 2460–2470.

    PubMed  Google Scholar 

  • Duker, P. C. (1975). Use of aversive shock therapy on a retarded girl with self destructive behaviors. Zeitschrift für Klinische Psychologie, 4(1), 38–47.

    Google Scholar 

  • Duncan, D., Matson, J. L., Bamburg, J. W., Cherry, K. E., & Buckley, T. (1999). The relationship of self-injurious behavior and aggression to social skills in persons with severe and profound learning disability. Research in Developmental Disabilities, 20(6), 441–448.

    PubMed  Google Scholar 

  • Dykens, E. M., Cassidy, S. B., & King, B. H. (1999). Maladaptive behavior differences in Prader-Willi syndrome due to paternal deletion versus maternal uniparental disomy. American Journal on Mental Retardation, 104(1), 67–77.

    PubMed  Google Scholar 

  • Eidelberg, E., & Erspamer, R. (1975). Dopaminergic mechanisms of opiate actions in brain. The Journal of Pharmacology and Experimental Therapeutics, 192(1), 50–57.

    PubMed  Google Scholar 

  • Engel, J., & Berggren, U. (1980). Effects of lithium on behaviour and central monoamines. Acta Psychiatrica Scandinavica, 280, S133–S143.

    Google Scholar 

  • Ernst, M. (2000). Commentary: Considerations on the characterization and treatment of self-injurious behavior. Journal of Autism and Developmental Disorders, 30(5), 447–450.

    PubMed  Google Scholar 

  • Espie, C. A., Watkins, J., Curtice, L., Espie, A., Duncan, R., Ryan, J. A., et al. (2003). Psychopathology in people with epilepsy and intellectual disability; an investigation of potential explanatory variables. Journal of Neurology, Neurosurgery and Psychiatry, 74(11), 1485–1492.

    PubMed Central  PubMed  Google Scholar 

  • Farber, J. M. (1987). Psychopharmacology of self-injurious behavior in the mentally retarded. Journal of the American Academy of Child and Adolescent Psychiatry, 26(3), 296–302.

    PubMed  Google Scholar 

  • Fatemi, S. H., Folsom, T. D., Reutiman, T. J., & Thuras, P. D. (2009). Expression of GABA(B) receptors is altered in brains of subjects with autism. Cerebellum, 8(1), 64–69.

    PubMed Central  PubMed  Google Scholar 

  • Fisher, W. W., Groff, R. A., & Roane, H. S. (2011). Applied behavior analysis. In W. W. Fisher, C. C. Piazza, & H. S. Roane (Eds.), Handbook of applied behavior analysis (pp. 3–16). New York: Guilford Press.

    Google Scholar 

  • Fontenot, M. B., Musso, M. W., McFatter, R. M., & Anderson, G. M. (2009). Dose-finding study of fluoxetine and venlafaxine for the treatment of self-injurious and stereotypic behavior in rhesus macaques (Macaca mulatta). Journal of the American Association for Laboratory Animal Science, 48(2), 176–184.

    PubMed Central  PubMed  Google Scholar 

  • Fontenot, M. B., Padgett, E. E, I. I. I., Dupuy, A. M., Lynch, C. R., De Petrillo, P. B., & Higley, J. D. (2005). The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. Comparative Medicine, 55(1), 67–74.

    PubMed  Google Scholar 

  • Garber, H. J., McGonigle, J. J., Slomka, G. T., & Monteverde, E. (1992). Clomipramine treatment of stereotypic behaviors and self-injury in patients with developmental disabilities. Journal of the Amercian Academy of Child and Adolescent Psychiatry, 31(6), 1157–1160.

    Google Scholar 

  • Glick, I. D., Murray, S. R., Vasudevan, P., Marder, S. R., & Hu, R. J. (2001). Treatment with atypical antipsychotics: New indications and new populations. Journal of Psychiatric Research, 35(3), 187–191.

    PubMed  Google Scholar 

  • Goldstein, M. (1989). Dopaminergic mechanisms in self-inflicting biting behavior. Psychopharmacology Bulletin, 25(3), 349–352.

    PubMed  Google Scholar 

  • Goldstein, M., Anderson, L. T., Reuben, R., & Dancis, J. (1985). Self-mutilation in Lesch-Nyhan disease is caused by dopaminergic denervation. Lancet, 1(8424), 338–339.

    PubMed  Google Scholar 

  • Gossler, A., Schalamon, J., Huber-Zeyringer, A., & Hollwarth, M. E. (2007). Gastroesophageal reflux and behavior in neurologically impaired children. Journal of Pediatric Surgery, 42(9), 1486–1490.

    PubMed  Google Scholar 

  • Granger, P., Biton, B., Faure, C., Vige, X., Depoortere, H., Graham, D., et al. (1995). Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin. Molecular Pharmacology, 47(6), 1189–1196.

    PubMed  Google Scholar 

  • Greenberg, A., & Coleman, M. (1973). Depressed whole blood serotonin levels associated with behavioral abnormalities in the de Lange syndrome. Pediatrics, 52(5), 720–724.

    PubMed  Google Scholar 

  • Gualtieri, C. T. (1989). The differential diagnosis of self-injurious behavior in mentally retarded people. Psychopharmacology Bulletin, 25(3), 358–363.

    PubMed  Google Scholar 

  • Gualtieri, C. T., & Schroeder, S. R. (1989). Pharmacotherapy for self-injurious behavior: Preliminary tests of the D1 hypothesis. Psychopharmacology Bulletin, 25(3), 364–371.

    PubMed  Google Scholar 

  • Guptill, J. T., Booker, A. B., Gibbs, T. T., Kemper, T. L., Bauman, M. L., & Blatt, G. J. (2007). [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: A multiple concentration autoradiographic study. Journal of Autism and Developmental Disorders, 37(5), 911–920.

    PubMed  Google Scholar 

  • Hammock, R., Levine, W. R., & Schroeder, S. R. (2001). Brief report: Effects of clozapine on self-injurious behavior of two risperidone nonresponders with mental retardation. Journal of Autism and Developmental Disorders, 31(1), 109–113.

    PubMed  Google Scholar 

  • Hanley, H. G., Stahl, S. M., & Freedman, D. X. (1977). Hyperserotonemia and amine metabolites in autistic and retarded children. Archives of General Psychiatry, 34(5), 521–531.

    PubMed  Google Scholar 

  • Hardan, A. Y., Minshew, N. J., & Keshavan, M. S. (2000). Corpus callosum size in autism. Neurology, 55(7), 1033–1036.

    PubMed  Google Scholar 

  • Hassiotis, A., Parkes, C., Jones, L., Fitzgerald, B., & Romeo, R. (2008). Individual characteristics and service expenditure on challenging behaviour for adults with intellectual disabilities. Journal of Applied Research in Intellectual Disabilities, 21(5), 438–445.

    Google Scholar 

  • Hedges, D., Jeppson, K., & Whitehead, P. (2003). Antipsychotic medication and seizures: A review. Drugs Today, 39(7), 551–557.

    PubMed  Google Scholar 

  • Hellings, J. A., & Warnock, J. K. (1994). Self-injurious behavior and serotonin in Prader-Willi syndrome. Psychopharmacology Bulletin, 30(2), 245–250.

    PubMed  Google Scholar 

  • Hellings, J. A., Weckbaugh, M., Nickel, E. J., Cain, S. E., Zarcone, J. R., Reese, R. M., et al. (2005). A double-blind, placebo-controlled study of valproate for aggression in youth with pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology, 15(4), 682–692.

    PubMed  Google Scholar 

  • Hollander, E., Wasserman, S., Swanson, E. N., Chaplin, W., Schapiro, M. L., Zagursky, K., et al. (2006). A double-blind placebo-controlled pilot study of olanzapine in childhood/adolescent pervasive developmental disorder. Journal of Child and Adolescent Psychopharmacology, 16(5), 541–548.

    PubMed  Google Scholar 

  • Holson, R. R., Scallet, A. C., Ali, S. F., Sullivan, P., & Gough, B. (1988). Adrenocortical, beta-endorphin and behavioral responses to graded stressors in differentially reared rats. Physiology & Behavior, 42(2), 125–130.

    Google Scholar 

  • Horner, R. H., Day, H. M., & Day, J. R. (1997). Using neutralizing routines to reduce problem behaviors. Journal of Applied Behavior Analysis, 30(4), 601–614.

    PubMed Central  PubMed  Google Scholar 

  • Horner, R. H., Day, H. M., Sprague, J. R., & O’Brien, M. (1991). Interspersed requests: A nonaversive procedure for reducing aggression and self-injury during instruction. Journal of Applied Behavior Analysis, 24(2), 265–278.

    PubMed Central  PubMed  Google Scholar 

  • Horsthemke, B., & Wagstaff, J. (2008). Mechanisms of imprinting of the Prader-Willi/Angelman region. American Journal of Medical Genetics, 146A(16), 2041–2052.

    PubMed  Google Scholar 

  • Hurwitz, S., & Minshawi, N. (2012). Methods of defining and observing behaviors. In J. L. Matson (Ed.), Functional assessment for challenging behaviors (pp. 91–103). New York: Springer Science + Business Media LLC.

    Google Scholar 

  • Iwata, B. A., Dorsey, M. F., Slifer, K. J., & Bauman, K. E. (1994a). Toward a functional analysis of self-injury. Journal of Applied Behavior Analysis, 27(2), 197–209.

    PubMed Central  PubMed  Google Scholar 

  • Iwata, B. A., Pace, G. M., Dorsey, M. F., & Zarcone, J. R. (1994b). The functions of self-injurious behavior: An experimental-epidemiological analysis. Journal of Applied Behavior Analysis, 27(2), 215–240.

    PubMed Central  PubMed  Google Scholar 

  • Iwata, B. A., Pace, G. M., Kalsher, M. J., & Cowdery, G. E. (1990a). Experimental analysis and extinction of self-injurious escape behavior. Journal of Applied Behavior Analysis, 23(1), 11–27.

    PubMed Central  PubMed  Google Scholar 

  • Iwata, B. A., Vollmer, T. R., & Zarcone, J. R. (1990b). The experimental (functional) analysis of behavior disorders: Methodology, applications, and limitations. In A. C. Repp (Ed.), Perspectives on the use of nonaversive and aversive interventions for persons with developmental disabilities (pp. 301–330). Illinois: Sycamore Publishing Company.

    Google Scholar 

  • Jankovic, J., Caskey, T. C., Stout, J. T., & Butler, I. J. (1988). Lesch-Nyhan syndrome: A study of motor behavior and cerebrospinal fluid neurotransmitters. Annals of Neurology, 23(5), 466–469.

    PubMed  Google Scholar 

  • Janowsky, D. S., Barnhill, L. J., & Davis, J. M. (2003). Olanzapine for self-injurious, aggressive, and disruptive behaviors in intellectually disabled adults: A retrospective, open-label, naturalistic trial. The Journal of Clinical Psychiatry, 64(10), 1258–1265.

    PubMed  Google Scholar 

  • Janowsky, D. S., Barnhill, L. J., Shetty, M., & Davis, J. M. (2005). Minimally effective doses of conventional antipsychotic medications used to treat aggression, self-injurious and destructive behaviors in mentally retarded adults. Journal of Clinical Psychopharmacology, 25(1), 19–25.

    PubMed  Google Scholar 

  • Jennett, H., Hagopian, L. P., & Beaulieu, L. (2011). Analysis of heart rate and self-injury with and without restraint in an individual with autism. Research in Autism Spectrum Disorders, 5(3), 1110–1118.

    Google Scholar 

  • Jinnah, H. A., Gage, F. H., & Friedmann, T. (1990). Animal models of Lesch-Nyhan syndrome. Brain Research Bulletin, 25(3), 467–475.

    PubMed  Google Scholar 

  • Jinnah, H. A., Vissar, J. E., Harris, J. C., Verdu, A., Larovere, L., Ceballos-Piscot, I., et al. (2006). Delineation of the motor disorder of Lesch-Nyhan disease. Brain, 129(5), 1201–1217.

    PubMed Central  PubMed  Google Scholar 

  • Jordan, I., Robertson, D., Catani, M., Craig, M., & Murphy, D. (2012). Aripiprazole in the treatment of challenging behaviour in adults with autism spectrum disorder. Psychopharmacology (Berl), 223(3), 357–360.

    Google Scholar 

  • Kaplan, G. B., & Leite-Morris, B. S. (2002). Introduction to neuronal signaling pathways. In G. B. Kaplan & R. P. Hammer (Eds.), Brain circuitry and signaling in psychiatry (pp. 31–62). Washington, DC: American Psychiatric Publishing Inc.

    Google Scholar 

  • Kelley, M. E., LaRue, R. H., Roane, H. S., & Gadaire, D. M. (2011). Indirect behavioral assessments: Interviews and rating scales. In W. W. Fisher, C. C. Piazza, & H. S. Roane (Eds.), Handbook of applied behavior analysis (pp. 182–205). New York: Guilford Press.

    Google Scholar 

  • Kemp, A. S., Fillmore, P. T., Lenjavi, M. R., Lyon, M., Chicz-Demet, A., Touchette, P. E., et al. (2008). Temporal patterns of self-injurious behavior correlate with stress hormone levels in the developmentally disabled. Psychiatry Research, 157(1), 181–189.

    PubMed Central  PubMed  Google Scholar 

  • Kern, L., Gallagher, P., Starosta, K., Hickman, W., & George, M. (2006). Longitudinal outcomes of functional behavioral assessment-based intervention. Journal of Positive Behavior Interventions, 8(2), 67–78.

    Google Scholar 

  • King, B. H. (1993). Self-injury by people with mental retardation: A compulsive behavior hypothesis. American Journal of Mental Retardation, 98(1), 93–112.

    PubMed  Google Scholar 

  • King, B. H. (2000). Pharmacological treatment of mood disturbances, aggression, and self-injury in persons with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 30(5), 439–445.

    PubMed  Google Scholar 

  • King, B. H., Cromwell, H. C., Lee, H. T., Behrstock, S. P., Schmanke, T., & Maidment, N. T. (1998). Dopaminergic and glutamatergic interactions in the expression of self-injurious behavior. Developmental Neuroscience, 20(2–3), 180–187.

    PubMed  Google Scholar 

  • Knapp, M., Comas-Herrera, A., Astin, J., Beecham, J., & Pendaries, C. (2005). Intellectual disability, challenging behaviour and cost in care accommodation: What are the links? Health and Social Care in the Community, 13(4), 297–306.

    PubMed  Google Scholar 

  • Kraemer, G. W., & Clarke, A. S. (1990). The behavioral neurobiology of self-injurious behavior in rhesus monkeys. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 14, S141–S168.

    PubMed  Google Scholar 

  • La Malfa, G. P., Bertelli, M., Ricca, V., Mannucci, E., & Cabras, P. L. (1997). Fluvoxamine and mental retardation: Clinical use. Italian Journal of Intellective Impairment, 10, 3–6.

    Google Scholar 

  • Lakin, K. C., Hill, B. K., Hauber, F. A., Bruininks, R. H., & Heal, L. W. (1983). New admissions and readmissions to a national sample of public residential facilities. American Journal of Mental Deficiency, 88, 13–20.

    Google Scholar 

  • Le Vann, L. J. (1971). Clinical comparison of haloperidol with chlorpromazine in mentally retarded children. American Journal of Mental Deficiency, 75(6), 719–723.

    PubMed  Google Scholar 

  • Leboyer, M., Bouvard, M. P., Launay, J. M., Recasens, C., Plumet, M. H., Waller-Perotte, D., et al. (1993). Opiate hypothesis in infantile autism? Therapeutic trials with naltrexone. L’Encephale, 19(2), 95–102.

    Google Scholar 

  • Lecavalier, L., Leone, S., & Wiltz, J. (2006). The impact of behaviour problems on caregiver stress in young people with autism spectrum disorders. Journal of Intellectual Disability Research, 50(3), 172–183.

    PubMed  Google Scholar 

  • Leite-Morris, K. A., Fukudome, E. Y., & Kaplan, G. B. (2002). Opiate-induced motor stimulation is regulated by gamma-aminobutyric acid type B receptors found in the ventral tegmental area in mice. Neuroscience Letters, 317(3), 119–122.

    PubMed  Google Scholar 

  • Lejeune, J., Lafourcade, J., Berger, R., Vialatte, J., Boeswillwald, M., Seringe, P., et al. (1963). 3 cases of partial deletion of the short arm of a 5 chromosome. Comptes Rendus Hebdomadaires des Seances de l’Academie des Sciences, 257, 3098–3102.

    PubMed  Google Scholar 

  • Lequia, J., Machalicek, W., & Rispoli, M. J. (2012). Effects of activity schedules on challenging behavior exhibited in children with autism spectrum disorders: A systematic review. Research in Autism Spectrum Disorders, 6(1), 480–492.

    Google Scholar 

  • Lewis, M. H., Bodfish, J. W., Powell, S. B., Parker, D. E., & Golden, R. N. (1996). Clomipramine treatment for self-injurious behavior of individuals with mental retardation: A double-blind comparison with placebo. American Journal of Mental Retardation, 100(6), 654–665.

    PubMed  Google Scholar 

  • Lewis, M. H., Gluck, J. P., Beauchamp, A. J., Keresztury, M. F., & Mailman, R. B. (1990). Long-term effects of early social isolation in Macaca mulatta: Changes in dopamine receptor function following apomorphine challenge. Brain Research, 513(1), 67–73.

    PubMed  Google Scholar 

  • Lindauer, S. E., DeLeon, I. G., & Fisher, W. W. (1999). Decreasing signs of negative affect and correlated self-injury in an individual with mental retardation and mood disturbances. Journal of Applied Behavior Analysis, 32(1), 103–106.

    PubMed Central  PubMed  Google Scholar 

  • Lindberg, J. S., Iwata, B. A., Roscoe, E. M., Worsdell, A. S., & Hanley, G. P. (2003). Treatment efficacy of noncontingent reinforcement during brief and extended application. Journal of Applied Behavior Analysis, 36(1), 1–19.

    PubMed Central  PubMed  Google Scholar 

  • Lloyd, K. G., Hornykiewicz, O., Davidson, L., Shannak, K., Farley, I., Goldstein, M., et al. (1981). Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome. The New England Journal of Medicine, 305(19), 1106–1111.

    PubMed  Google Scholar 

  • Loh, H. H., Brase, D. A., Sampath-Khanna, S., Mar, J. B., Way, E. L., & Li, C. H. (1976). Beta-endorphin in vitro inhibition of striatal dopamine release. Nature, 264(5586), 567–568.

    PubMed  Google Scholar 

  • Lotan, M., Ljunggren, E. A., Johnsen, T. B., Defrin, R., Pick, C. G., & Strand, L. I. (2009). A modified version of the non-communicating children pain checklist-revised, adapted to adults with intellectual and developmental disabilities: Sensitivity to pain and internal consistency. The Journal of Pain, 10(4), 398–407.

    PubMed  Google Scholar 

  • Luiselli, J. K. (1992). Assessment and treatment of self-injury in a deaf-blind child. Journal of Developmental and Physical Disabilities, 4(3), 219–226.

    Google Scholar 

  • Luiselli, J. K., Cochran, M. L., & Huber, S. A. (2005). Effects of otitis media on a child with autism receiving behavioral intervention for self-injury. Child & Family Behavior Therapy, 27(2), 51–56.

    Google Scholar 

  • MacLean, W. E., Tervo, R. C., Hoch, J., Tervo, M., & Symons, F. J. (2010). Self-injury among a community cohort of young children at risk for intellectual and developmental disabilities. The Journal of Pediatrics, 157(6), 979–983.

    PubMed  Google Scholar 

  • Magee, S. K., & Ellis, J. (2000). Extinction effects during the assessment of multiple problem behaviors. Journal of Applied Behavior Analysis, 33(3), 313–316.

    PubMed Central  PubMed  Google Scholar 

  • Major, C. A., Kelly, B. J., Novak, M. A., Davenport, M. D., Stonemetz, K. M., & Meyer, J. S. (2009). The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). Life Sciences, 85(21–22), 753–758.

    PubMed Central  PubMed  Google Scholar 

  • Mandell, D. S. (2008). Psychiatric hospitalization among children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 38(6), 1059–1065.

    PubMed Central  PubMed  Google Scholar 

  • Marcus, R. N., Owen, R., Kamen, L., Manos, G., McQuade, R. D., Carson, W. H., et al. (2009). A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 48(11), 1110–1119.

    PubMed  Google Scholar 

  • Marholin, D, I. I., Touchette, P. E., & Stewart, R. M. (1979). Withdrawal of chronic chlorpromazine medication: An experimental analysis. Journal of Applied Behavior Analysis, 12(2), 159–171.

    PubMed Central  PubMed  Google Scholar 

  • Matson, J. L., Bamburg, J. W., Mayville, E. A., & Khan, I. (1999). Seizure disorders in people with intellectual disability: An analysis of differences in social functioning, adaptive functioning and maladaptive behaviours. Journal of Intellectual Disability Research, 43(6), 531–539.

    PubMed  Google Scholar 

  • Matson, J. L., & LoVullo, S. V. (2008). A review of behavioral treatments for self-injurious behaviors of persons with autism spectrum disorders. Behavior Modification, 32(1), 61–76.

    PubMed  Google Scholar 

  • Matthews, T., Weston, N., Baxter, H., Felce, D., & Kerr, M. (2008). A general practice-based prevalence study of epilepsy among adults with intellectual disabilities and of its association with psychiatric disorder, behaviour disturbance and career stress. Journal of Intellectual Disability Research, 52(2), 163–173.

    PubMed  Google Scholar 

  • McDonough, M., Hillery, J., & Kennedy, N. (2000). Olanzapine for chronic, stereotypic self-injurious behaviour: A pilot study in seven adults with intellectual disability. Journal of Intellectual Disability Research, 44(6), 677–684.

    PubMed  Google Scholar 

  • McDougle, C. J. (2013). Sounding a wake-up call: Improving the lives of adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 52(6), 566–568.

    PubMed  Google Scholar 

  • McDougle, C. J., Naylor, S. T., Cohen, D. J., Aghajanian, G. K., Heninger, G. R., & Price, L. H. (1996a). Effects of tryptophan depletion in drug-free adults with autistic disorder. Archives of General Psychiatry, 53(11), 993–1000.

    PubMed  Google Scholar 

  • McDougle, C. J., Naylor, S. T., Cohen, D. J., Volkmar, F. R., Heninger, G. R., & Price, L. H. (1996b). A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Archives of General Psychiatry, 53(11), 1001–1008.

    PubMed  Google Scholar 

  • McElroy, S. L., Keck, P. E., Pope, H. G., & Hudson, J. I. (1989). Valproate in psychiatric disorders: Literature review and clinical guidelines. The Journal of Clinical Psychiatry, 50, S23–S29.

    Google Scholar 

  • McManaman, J., & Tam, D. A. (1999). Gabapentin for self-injurious behavior in Lesch-Nyhan syndrome. Pediatric Neurology, 20(5), 381–382.

    PubMed  Google Scholar 

  • McNally, G. P., & Akil, H. (2002). Endogenous opioid peptides and their receptors: Overview and function in pain modulation. In K. L. Davis, D. Charney, J. T. Coyle, & C. Nemeroff (Eds.), Neuropsychopharmacology: The fifth generation of progress (pp. 35–46). New York: Lippincott Williams Wilkins.

    Google Scholar 

  • Mesibov, G. B., Browder, D. M., & Kirkland, C. (2002). Using individualized schedules as a component of positive behavioral support for students with developmental disabilities. Journal of Positive Behavior Interventions, 4(2), 73–79.

    Google Scholar 

  • Micev, V., & Lynch, D. M. (1974). Effect of lithium on disturbed severely mentally retarded patients. The British Journal of Psychiatry, 125(584), 110.

    PubMed  Google Scholar 

  • Miller, D. T., Adam, M. P., Aradhya, S., Biesecker, L. G., Brothman, A. R., Carter, N. P., et al. (2010). Consensus statement: Chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. American Journal of Human Genetics, 86(5), 749–764.

    PubMed Central  PubMed  Google Scholar 

  • Miyamoto, S., Duncan, G. E., Goff, D. C., & Lieberman, J. A. (2002). Therapeutics of schizophrenia. In K. L. Davis, D. Charney, J. T. Coyle, & C. Nemeroff (Eds.), Neuropsychopharmacology: The fifth generation of progress (pp. 777–797). Philidelphia, PA: Lippincott Williams & Wilkins.

    Google Scholar 

  • Mizuno, T. I., & Yugari, Y. (1974). Letter: Self mutilation in Lesch-Nyhan syndrome. Lancet, 1(7860), 761.

    PubMed  Google Scholar 

  • Mizuno, T., & Yugari, Y. (1975). Prophylactic effect of L-5-hydroxytryptophan on self-mutilation in the Lesch-Nyhan syndrome. Neuropadiatrie, 6(1), 13–23.

    Google Scholar 

  • Moreno-Fuenmayor, H., Borjas, L., Arrieta, A., Valera, V., & Socorro-Candanoza, L. (1996). Plasma excitatory amino acids in autism. Investigacion Clinica, 37(2), 113–128.

    PubMed  Google Scholar 

  • Morgan, J. R., Storch, E. A., Woods, D. W., Bodzin, D., Lewin, A. B., & Murphy, T. K. (2010). A preliminary analysis of the phenomenology of skin-picking in Prader-Willi syndrome. Child Psychiatry and Human Development, 41(4), 448–463.

    PubMed  Google Scholar 

  • Mori, T., Ito, S., Kita, T., Narita, M., Suzuki, T., Matsubayashi, K., et al. (2007). Oxidative stress in methamphetamine-induced self-injurious behavior in mice. Behavioural Pharmacology, 18(3), 239–249.

    PubMed  Google Scholar 

  • Mori, T., Ito, S., Kita, T., & Sawaguchi, T. (2004). Effects of dopamine- and serotonin-related compounds on methamphetamine-induced self-injurious behavior in mice. Journal of Pharmacological Sciences, 96(4), 459–464.

    PubMed  Google Scholar 

  • Muehlmann, A. M., Brown, B. D., & Devine, D. P. (2008). Pemoline (2-amino-5-phenyl-1,3-oxazol-4-one)-induced self-injurious behavior: A rodent model of pharmacotherapeutic efficacy. The Journal of Pharmacology and Experimental Therapeutics, 324(1), 214–223.

    PubMed  Google Scholar 

  • Muehlmann, A. M., & Devine, D. P. (2008). Glutamate-mediated neuroplasticity in an animal model of self-injurious behaviour. Behavioural Brain Research, 189(1), 32–40.

    PubMed  Google Scholar 

  • Muehlmann, A. M., Kies, S. D., Turner, C. A., Wolfman, S., Lewis, M. H., & Devine, D. P. (2012). Self-injurious behaviour: Limbic dysregulation and stress effects in an animal model. Journal of Intellectual Disability Research, 56(5), 490–500.

    PubMed  Google Scholar 

  • Muehlmann, A. M., Wilkinson, J. A., & Devine, D. P. (2011). Individual differences in vulnerability for self-injurious behavior: Studies using an animal model. Behavioural Brain Research, 217(1), 148–154.

    PubMed Central  PubMed  Google Scholar 

  • Novak, M. A. (2003). Self-injurious behavior in rhesus monkeys: New insights into its etiology, physiology, and treatment. American Journal of Primatology, 59(1), 3–19.

    PubMed  Google Scholar 

  • Nyhan, W. L. (1972). Behavioral phenotypes in organic genetic disease: Presidential address to the Society for Pediatric Research, May 1, 1971. Pediatric Research, 6(1), 1–9.

    PubMed  Google Scholar 

  • Nyhan, W. L. (1973). The Lesch-Nyhan syndrome. Annual Review of Medicine, 24, 41–60.

    PubMed  Google Scholar 

  • Nyhan, W. L. (1997). The recognition of Lesch-Nyhan syndrome as an inborn error of purine metabolism. Journal of Inherited Metabolic Disease, 20(2), 171–178.

    PubMed  Google Scholar 

  • Nyhan, W. L., Johnson, H. G., Kaufman, I. A., & Jones, K. L. (1980). Serotonergic approaches to the modification of behavior in the Lesch-Nyhan syndrome. Applied Research in Mental Retardation, 1(1), 25–40.

    PubMed  Google Scholar 

  • Oblak, A., Gibbs, T. T., & Blatt, G. J. (2009). Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Research, 2(4), 205–219.

    PubMed Central  PubMed  Google Scholar 

  • Oliver, C., Sloneem, J., Hall, S., & Arron, K. (2009). Self-injurious behaviour in Cornelia de Lange syndrome: 1. Prevalence and phenomenology. Journal of Intellectual Disability Research, 53(7), 575–589.

    PubMed  Google Scholar 

  • Oltras, C. M., Mora, F., & Vives, F. (1987). Beta-endorphin and ACTH in plasma: Effects of physical and psychological stress. Life Sciences, 40(17), 1683–1686.

    PubMed  Google Scholar 

  • Orr, R. (1993). Age-related changes in stress experienced by families with a child who has developmental delays. Mental Retardation, 31(3), 171–176.

    PubMed  Google Scholar 

  • Osman, O. T., & Loschen, E. L. (1992). Self-injurious behavior in the developmentally disabled: Pharmacologic treatment. Psychopharmacology Bulletin, 28(4), 439–449.

    PubMed  Google Scholar 

  • Overhauser, J., Huang, X., Gersh, M., Wilson, W., McMahon, J., Bengtsson, U., et al. (1994). Molecular and phenotypic mapping of the short arm of chromosome 5: Sublocalization of the critical region for the cri-du-chat syndrome. Human Molecular Genetics, 3(2), 247–252.

    PubMed  Google Scholar 

  • Owen, R., Sikich, L., Marcus, R. N., Corey-Lisle, P., Manos, G., McQuade, R. D., et al. (2009). Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder. Pediatrics, 124(6), 1533–1540.

    PubMed  Google Scholar 

  • Parikh, M. S., Kolevzon, A., & Hollander, E. (2008). Psychopharmacology of aggression in children and adolescents with autism: A critical review of efficacy and tolerability. Journal of Child and Adolescent Psychopharmacology, 18(2), 157–178.

    PubMed  Google Scholar 

  • Patel, N. C., Crismon, M. L., Hoagwood, K., Johnsrud, M. T., Rascati, K. L., Wilson, J. P., et al. (2005). Trends in the use of typical and atypical antipsychotics in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 44(6), 548–556.

    PubMed  Google Scholar 

  • Peebles, K. A., & Price, T. J. (2012). Self-injurious behaviour in intellectual disability syndromes: Evidence for aberrant pain signalling as a contributing factor. Journal of Intellectual Disability Research, 56(5), 441–452.

    PubMed Central  PubMed  Google Scholar 

  • Pfeffer, C. R., Jiang, H., & Domeshek, L. J. (1997). Buspirone treatment of psychiatrically hospitalized prepubertal children with symptoms of anxiety and moderately severe aggression. Journal of Child and Adolescent Psychopharmacology, 7(3), 145–155.

    PubMed  Google Scholar 

  • Piazza, C. C., Adelinis, J. D., Hanley, G. P., Goh, H., & Delia, M. D. (2000). An evaluation of the effects of matched stimuli on behaviors maintained by automatic reinforcement. Journal of Applied Behavior Analysis, 33(1), 13–27.

    PubMed Central  PubMed  Google Scholar 

  • Piazza, C. C., Fisher, W. W., & Kahng, S. W. (1996). Sleep patterns in children and young adults with mental retardation and severe behavior disorders. Developmental Medicine and Child Neurology, 38(4), 335–344.

    PubMed  Google Scholar 

  • Politte, L. C., & McDougle, C. J. (2014). Atypical antipsychotics in the treatment of children and adolescents with pervasive developmental disorders. Psychopharmacology (Berl), 231(6), 1023–1036.

    Google Scholar 

  • Posey, D. J., Stigler, K. A., Erickson, C. A., & McDougle, C. J. (2008). Antipsychotics in the treatment of autism. Journal of Clinical Investigation, 118(1), 6–14.

    PubMed Central  PubMed  Google Scholar 

  • Potenza, M. N., Holmes, J. P., Kanes, S. J., & McDougle, C. J. (1999). Olanzapine treatment of children, adolescents, and adults with pervasive developmental disorders: An open-label pilot study. Journal of Clinical Psychopharmacology, 19(1), 37–44.

    PubMed  Google Scholar 

  • Privitera, M. D. (1997). Topiramate: A new antiepileptic drug. The Annals of Pharmacotherapy, 31(10), 1164–1173.

    PubMed  Google Scholar 

  • Quine, L. (1991). Sleep problems in children with mental handicap. Journal of Mental Deficiency Research, 35(4), 269–290.

    PubMed  Google Scholar 

  • Quine, S. (1993). Stressors experienced by relatives of patients in an innovative rehabilitation program. Health and Social Work, 18(2), 114–122.

    PubMed  Google Scholar 

  • Ratey, J. J., Sovner, R., Mikkelsen, E., & Chmielinski, H. E. (1989). Buspirone therapy for maladaptive behavior and anxiety in developmentally disabled persons. The Journal of Clinical Psychiatry, 50(10), 382–384.

    PubMed  Google Scholar 

  • Reisberg, B., & Gershon, S. (1979). Side effects associated with lithium therapy. Archives of General Psychiatry, 36(8), 879–887.

    PubMed  Google Scholar 

  • Riblet, L. A., Taylor, D. P., Elson, M. S., & Stanton, H. C. (1982). Pharmacology and neurochemistry of buspirone. Journal of Clinical Psychiatry, 43(12), 11–16.

    PubMed  Google Scholar 

  • Richardson, J. S., & Zaleski, W. A. (1983). Naloxone and self-mutilation. Biological Psychiatry, 18(1), 99–101.

    PubMed  Google Scholar 

  • Richman, D. M., Barnard-Brak, L., Bosch, A., Thompson, S., Grubb, L., & Abby, L. (2013). Predictors of self-injurious behaviour exhibited by individuals with autism spectrum disorder. Journal of Intellectual Disability Research, 57(5), 429–439.

    PubMed  Google Scholar 

  • Ricketts, R. W., Goza, A. B., Ellis, C. R., Singh, Y. N., Chambers, S., Singh, N. N., et al. (1994). Clinical effects of buspirone on intractable self-injury in adults with mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry, 33(2), 270–276.

    PubMed  Google Scholar 

  • Roach, E. S., Delgado, M., Anderson, L., Iannaccone, S. T., & Burns, D. K. (1996). Carbamazepine trial for Lesch-Nyhan self-mutilation. Journal of Child Neurology, 11(6), 476–478.

    PubMed  Google Scholar 

  • Roby-Brami, A., Bussel, B., Willer, J. C., & Le Bars, D. (1987). An electrophysiological investigation into the pain-relieving effects of heterotopic nociceptive stimuli: Probable involvement of a supraspinal loop. Brain, 110(6), 1497–1508.

    PubMed  Google Scholar 

  • Rohatgi, S., Clark, D., Kline, A. D., Jackson, L. G., Pie, J., Siu, V., et al. (2010). Facial diagnosis of mild and variant CdLS: Insights from a dysmorphologist survey. American Journal of Medical Genetics, 152A(7), 1641–1653.

    PubMed  Google Scholar 

  • Rojahn, J., Wilkins, J., Matson, J. L., & Boisjoli, J. (2010). A comparison of adults with intellectual disabilities with and without ASD on parallel measures of challenging behaviour: The behavior problems inventory-01 (BPI-01) and Autism spectrum disorders-behavior problems for intellectually disabled adults (ASD-BPA). Journal of Applied Research in Intellectual Disabilities, 23(2), 179–185.

    Google Scholar 

  • Ruedrich, S., Swales, T. P., Fossaceca, C., Toliver, J., & Rutkowski, A. (1999). Effect of divalproex sodium on aggression and self-injurious behaviour in adults with intellectual disability: A retrospective review. Journal of Intellectual Disability Research, 43(2), 105–111.

    PubMed  Google Scholar 

  • Ruedrich, S. L., Swales, T. P., Rossvanes, C., Diana, L., Arkadiev, V., & Lim, K. (2008). Atypical antipsychotic medication improves aggression, but not self-injurious behaviour, in adults with intellectual disabilities. Journal of Intellectual Disability Research, 52(2), 132–140.

    PubMed  Google Scholar 

  • Saito, Y., & Takashima, S. (2000). Neurotransmitter changes in the pathophysiology of Lesch-Nyhan syndrome. Brain and Development, 22, S122–S131.

    PubMed  Google Scholar 

  • Sampat, R., Fu, R., Larovere, L. E., Torres, R. J., Ceballos-Picot, I., Fischbach, M., et al. (2011). Mechanisms for phenotypic variation in Lesch-Nyhan disease and its variants. Human Genetics, 129(1), 71–78.

    PubMed Central  PubMed  Google Scholar 

  • Sandman, C. A., Barron, J. L., Chicz-DeMet, A., & DeMet, E. M. (1990). Plasma B-endorphin levels in patients with self-injurious behavior and stereotypy. American Journal of Mental Retardation, 95(1), 84–92.

    PubMed  Google Scholar 

  • Sandman, C. A., Datta, P. C., Barron, J., Hoehler, F. K., Williams, C., & Swanson, J. M. (1983). Naloxone attenuates self-abusive behavior in developmentally disabled clients. Applied Research in Mental Retardation, 4(1), 5–11.

    PubMed  Google Scholar 

  • Sandman, C. A., Hetrick, W., Taylor, D. V., & Chicz-DeMet, A. (1997). Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers. American Journal of Mental Retardation, 102(2), 182–199.

    PubMed  Google Scholar 

  • Sandman, C. A., Spence, M. A., & Smith, M. (1999). Proopiomelanocortin (POMC) disregulation and response to opiate blockers. Mental Retardation and Developmental Disabilities Research Reviews, 5(4), 314–321.

    Google Scholar 

  • Sandman, C. A., Touchette, P. E., Marion, S. D., & Chicz-DeMet, A. (2008). The role of proopiomelanocortin (POMC) in sequentially dependent self-injurious behavior. Developmental Psychobiology, 50(7), 680–689.

    PubMed Central  PubMed  Google Scholar 

  • Sassi, R. B., & Soares, J. C. (2002). Neural circuitry and signaling in bipolar disorder. In G. B. Kaplan & R. P. Hammer (Eds.), Brain circuitry and signaling in psychiatry (pp. 179–200). Washington, DC: American Psychiatric Publishing Inc.

    Google Scholar 

  • Scahill, L., Aman, M. G., McDougle, C. J., Arnold, L. E., McCracken, J. T., Handen, B., et al. (2009). Trial design challenges when combining medication and parent training in children with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 39(5), 720–729.

    PubMed  Google Scholar 

  • Schain, R. J., & Freedman, D. X. (1961). Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. The Journal of Pediatrics, 58, 315–320.

    PubMed  Google Scholar 

  • Schroeder, S. R., Oster-Granite, M. L., Berkson, G., Bodfish, J. W., Breese, G. R., Cataldo, M. F., et al. (2001). Self-injurious behavior: Gene–brain–behavior relationships. Mental Retardation and Developmental Disabilities Research Reviews, 7(1), 3–12.

    PubMed  Google Scholar 

  • Schroeder, S. R., Schroeder, C. S., Smith, B., & Dalldorf, J. (1978). Prevalence of self-injurious behaviors in a large state facility for the retarded: A three-year follow-up study. Journal of Autism and Childhood Schizophrenia, 8(3), 261–269.

    PubMed  Google Scholar 

  • Shakya, D. R., Shyangwa, P. M., Pandey, A. K., Subedi, S., & Yadav, S. (2010). Self injurious behavior in temporal lobe epilepsy. Journal of the Nepal Medical Association, 49(179), 239–242.

    PubMed  Google Scholar 

  • Shapira, N. A., Lessig, M. C., Murphy, T. K., Driscoll, D. J., & Goodman, W. K. (2002). Topiramate attenuates self-injurious behaviour in Prader-Willi syndrome. The International Journal of Neuropsychopharmacology, 5(2), 141–145.

    PubMed  Google Scholar 

  • Shinohe, A., Hashimoto, K., Nakamura, K., Tsujii, M., Iwata, Y., Tsuchiya, K. J., et al. (2006). Increased serum levels of glutamate in adult patients with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30(8), 1472–1477.

    PubMed  Google Scholar 

  • Siegel, M., Milligan, B., Robbins, D., & Prentice, G. (2012). Electroconvulsive therapy in an adolescent with autism and bipolar I disorder. The Journal of ECT, 28(4), 252–255.

    PubMed  Google Scholar 

  • Sigafoos, J., O’Reilly, M., Ma, C. H., Edrisinha, C., Cannella, H., & Lancioni, G. E. (2006). Effects of embedded instruction versus discrete-trial training on self-injury, correct responding, and mood in a child with autism. Journal of Intellectual and Developmental Disability, 31(4), 196–203.

    PubMed  Google Scholar 

  • Simeon, D., Stein, D. J., Gross, S., Islam, N., Schmeidler, J., & Hollander, E. (1997). A double-blind trial of fluoxetine in pathologic skin picking. The Journal of Clinical Psychiatry, 58(8), 341–347.

    PubMed  Google Scholar 

  • Singh, N. N., & Aman, M. G. (1981). Effects of thioridazine dosage on the behavior of severely mentally retarded persons. American Journal of Mental Deficiency, 85(6), 580–587.

    PubMed  Google Scholar 

  • Skinner, B. F. (1938). The behavior of organisms: An experimental analysis. Oxford, England: Appleton-Century.

    Google Scholar 

  • Smith, R. G. (2011). Developing antecedent interventions for problem behavior. In W. W. Fisher, C. C. Piazza, & H. S. Roane (Eds.), Handbook of applied behavior analysis (pp. 297–316). New York: Guilford Press.

    Google Scholar 

  • Snyder, R., Turgay, A., Aman, M., Binder, C., Fisman, S., & Carroll, A. (2002). Effects of risperidone on conduct and disruptive behavior disorders in children with subaverage IQs. Journal of the American Academy of Child and Adolescent Psychiatry, 41(9), 1026–1036.

    PubMed  Google Scholar 

  • Sohanpal, S. K., Deb, S., Thomas, C., Soni, R., Lenotre, L., & Unwin, G. (2007). The effectiveness of antidepressant medication in the management of behaviour problems in adults with intellectual disabilities: A systematic review. Journal of Intellectual Disability Research, 51(10), 750–765.

    PubMed  Google Scholar 

  • Sovner, R. (1986). Limiting factors in the use of DSM-III criteria with mentally ill/mentally retarded persons. Psychopharmacology Bulletin, 22(4), 1055–1059.

    PubMed  Google Scholar 

  • Sovner, R., Fox, C. J., Lowry, M. J., & Lowry, M. A. (1993). Fluoxetine treatment of depression and associated self-injury in two adults with mental retardation. Journal of Intellectual Disability Research, 37(3), 301–311.

    PubMed  Google Scholar 

  • Sprague, J. R., & Horner, R. H. (1995). Functional assessment and intervention in community settings. Mental Retardation and Developmental Disabilities Research Reviews, 1(2), 89–93.

    Google Scholar 

  • Sprague, R. L., & Werry, J. S. (1971). Methodology of psychopharmacological studies with the retarded. International Review of Research in Mental Retardation, 5, 147–219.

    Google Scholar 

  • Stein, D. J., Keating, J., Zar, H. J., & Hollander, E. (1994). A survey of the phenomenology and pharmacotherapy of compulsive and impulsive-aggressive symptoms in Prader-Willi syndrome. The Journal of Neuropsychiatry and Clinical Neurosciences, 6(1), 23–29.

    PubMed  Google Scholar 

  • Sterling-Turner, H. E., & Jordan, S. S. (2007). Interventions addressing transition difficulties for individuals with autism. Psychology in the Schools, 44(7), 681–690.

    Google Scholar 

  • Stigler, K. A., Diener, J. T., Kohn, A. E., Li, L., Erickson, C. A., Posey, D. J., et al. (2009). Aripiprazole in pervasive developmental disorder not otherwise specified and Asperger’s disorder: A 14-week, prospective, open-label study. Journal of Child and Adolescent Psychopharmacology, 19(3), 265–274.

    PubMed Central  PubMed  Google Scholar 

  • Stigler, K. A., Potenza, M. N., Posey, D. J., & McDougle, C. J. (2004). Weight gain associated with atypical antipsychotic use in children and adolescents: Prevalence, clinical relevance, and management. Pediatric Drugs, 6(1), 33–44.

    PubMed  Google Scholar 

  • Stout, R. J. (1990). Fluoxetine for the treatment of compulsive facial picking. American Journal of Psychiatry, 147(3), 370.

    PubMed  Google Scholar 

  • Stout, J. T., & Caskey, C. T. (1985). HPRT: Gene structure, expression, and mutation. Annual Review of Genetics, 19, 127–148.

    PubMed  Google Scholar 

  • Svendsen, C. N., Froimowitz, M., Hrbek, C., Campbell, A., Kula, N., Baldessarini, R. J., et al. (1988). Receptor affinity, neurochemistry and behavioral characteristics of the enantiomers of thioridazine: Evidence for different stereoselectivities at D1 and D2 receptors in rat brain. Neuropharmacology, 27(11), 1117–1124.

    PubMed  Google Scholar 

  • Symons, F. J., Butler, M. G., Sanders, M. D., Feurer, I. D., & Thompson, T. (1999). Self-injurious behavior and Prader-Willi syndrome: Behavioral forms and body locations. American Journal of Mental Retardation, 104(3), 260–269.

    PubMed  Google Scholar 

  • Symons, F. J., & Danov, S. E. (2005). A prospective clinical analysis of pain behavior and self-injurious behavior. Pain, 117(3), 473–477.

    PubMed  Google Scholar 

  • Tate, B. G., & Baroff, G. S. (1973). Aversive control of self-Injurious behavior in a psychotic boy. In J. M. Stedman, W. F. Patton, & K. F. Walton (Eds.), Clinical studies in behavior therapy with children, adolescents and their families (pp. 352–360). Springfield, IL: Charles C. Thomas Publisher.

    Google Scholar 

  • Taylor, D. V., Rush, D., Hetrick, W. P., & Sandman, C. A. (1993). Self-injurious behavior within the menstrual cycle of women with mental retardation. American Journal of Mental Retardation, 97(6), 659–664.

    PubMed  Google Scholar 

  • Thompson, R. H., & Borrero, J. C. (2011). Direct observation. In W. W. Fisher, C. C. Piazza, & H. S. Roane (Eds.), Handbook of applied behavior analysis (pp. 191–205). New York: Guilford Press.

    Google Scholar 

  • Tiefenbacher, S., Novak, M. A., Lutz, C. K., & Meyer, J. S. (2005). The physiology and neurochemistry of self-injurious behavior: A nonhuman primate model. Frontiers in Bioscience, 10, 1–11.

    PubMed  Google Scholar 

  • Tsiouris, J. A., Cohen, I. L., Patti, P. J., & Korosh, W. M. (2003). Treatment of previously undiagnosed psychiatric disorders in persons with developmental disabilities decreased or eliminated self-injurious behavior. The Journal of Clinical Psychiatry, 64(9), 1081–1090.

    PubMed  Google Scholar 

  • Tyrer, S. P., Walsh, A., Edwards, D. E., Berney, T. P., & Stephens, D. A. (1984). Factors associated with a good response to lithium in aggressive mentally handicapped subjects. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 8(4), 751–755.

    PubMed  Google Scholar 

  • Van der Zee, S. P., Schretlen, E. D., & Monnens, L. A. (1968). Megaloblastic anaemia in the Lesch-Nyhan syndrome. Lancet, 1(7557), 1427.

    PubMed  Google Scholar 

  • Van Erp, A. M., & Miczek, K. A. (2000). Aggressive behavior, increased accumbal dopamine, and decreased cortical serotonin in rats. Journal of Neuroscience, 20(24), 9320–9325.

    PubMed  Google Scholar 

  • Vandenbergh, D. J., Persico, A. M., Hawkins, A. L., Griffin, C. A., Li, X., Jabs, E. W., et al. (1992). Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics, 14(4), 1104–1106.

    PubMed  Google Scholar 

  • Veenstra-VanderWeele, J., & Anderson, G. M. (2011). The serotonin system in autism. In E. Hollander, A. Kolevzon, & J. T. Coyle (Eds.), Textbook of autism spectrum disorders (pp. 315–322). Washington, DC: American Psychiatric Publishing Inc.

    Google Scholar 

  • Vestergaard, P., Amdisen, A., & Schou, M. (1980). Clinically significant side effects of lithium treatment: A survey of 237 patients in long-term treatment. Acta Psychiatrica Scandinavica, 62(3), 193–200.

    PubMed  Google Scholar 

  • Vollmer, T. R., Iwata, B. A., Zarcone, J. R., & Smith, R. G. (1993). The role of attention in the treatment of attention-maintained self-injurious behavior: Noncontingent reinforcement and differential reinforcement of other behavior. Journal of Applied Behavior Analysis, 26(1), 9–21.

    PubMed Central  PubMed  Google Scholar 

  • Vollmer, T. R., Marcus, B. A., & LeBlanc, L. (1994). Treatment of self-injury and hand mouthing following inconclusive functional analyses. Journal of Applied Behavior Analysis, 27(2), 331–344.

    PubMed Central  PubMed  Google Scholar 

  • Wachtel, L. E., Contrucci-Kuhn, S. A., Griffin, M., Thompson, A., Dhossche, D. M., & Reti, I. M. (2009). ECT for self-injury in an autistic boy. European Child and Adolescent Psychiatry, 18(7), 458–463.

    PubMed  Google Scholar 

  • Wachtel, L. E., & Dhossche, D. M. (2010). Self-injury in autism as an alternate sign of catatonia: Implications for electroconvulsive therapy. Medical Hypotheses, 75(1), 111–114.

    PubMed  Google Scholar 

  • Wachtel, L. E., Griffin, M., & Reti, I. M. (2010). Electroconvulsive therapy in a man with autism experiencing severe depression, catatonia, and self-injury. The Journal of ECT, 26(1), 70–73.

    PubMed  Google Scholar 

  • Wallis, C. (2009). Respiratory health of people with profound intellectual and multiple disabilities. In J. Pawlyn & S. Carnaby (Eds.), Profound intellectual and multiple disabilities: Nursing complex needs (pp. 186–201). Hoboken: Wiley.

    Google Scholar 

  • Walters, A. S., Barrett, R. P., Feinstein, C., Mercurio, A., & Hole, W. T. (1990). A case report of naltrexone treatment of self-injury and social withdrawal in autism. Journal of Autism and Developmental Disorders, 20(2), 169–176.

    PubMed  Google Scholar 

  • Watt-Smith, P. (2009). Dental care and oral health. In J. Pawlyn & S. Carnaby (Eds.), Profound intellectual and multiple disabilities: Nursing complex needs (pp. 202–235). Hoboken: Wiley.

    Google Scholar 

  • West, S. A., Keck, P. E., & Mcelroy, S. L. (1995). Oral loading doses in the valproate treatment of adolescents with mixed bipolar disorder. Journal of Child and Adolescent Psychopharmacology, 5(3), 225–231.

    Google Scholar 

  • Willemsen-Swinkels, S. H., Buitelaar, J. K., Nijhof, G. J., & van Engeland, H. (1995). Failure of naltrexone hydrochloride to reduce self-injurious and autistic behavior in mentally retarded adults. Double-blind placebo-controlled studies. Archives of General Psychiatry, 52(9), 766–773.

    PubMed  Google Scholar 

  • Willer, J. C., Dehen, H., & Cambier, J. (1981). Stress-induced analgesia in humans: Endogenous opioids and naloxone-reversible depression of pain reflexes. Science, 212(4495), 689–691.

    PubMed  Google Scholar 

  • Williams, K., Wheeler, D. M., Silove, N., & Hazell, P. (2010). Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Cochrane Database of Systematic Reviews, (8), CD004677. doi:10.1002/14651858.CD004677.pub2.

  • Wilson, J. M., Young, A. B., & Kelley, W. N. (1983). Hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular basis of the clinical syndromes. The New England Journal of Medicine, 309(15), 900–910.

    PubMed  Google Scholar 

  • Wink, L. K., Erickson, C. A., & McDougle, C. J. (2010). Pharmacologic treatment of behavioral symptoms associated with autism and other pervasive developmental disorders. Current Treatment Options in Neurology, 12(6), 529–538.

    PubMed  Google Scholar 

  • Wolff, J. J., Hazlett, H. C., Lightbody, A. A., Reiss, A. L., & Piven, J. (2013). Repetitive and self-injurious behaviors: Associations with caudate volume in autism and fragile X syndrome. Journal of Neurodevelopmental Disorders, 5(1), 12.

    PubMed Central  PubMed  Google Scholar 

  • Wong, D. F., Harris, J. C., Naidu, S., Yokoi, F., Marenco, S., Dannals, R. F., et al. (1996). Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo. Proceedings of the National Academy of Sciences of the United States of America, 93(11), 5539–5543.

    PubMed Central  PubMed  Google Scholar 

  • Zhang, W., & Bymaster, F. P. (1999). The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D1, D2, D3, 5HT2A and muscarinic receptors. Psychopharmacology (Berl), 141(3), 267–278.

    Google Scholar 

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Authors and Affiliations

  1. Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA

    Noha F. Minshawi

  2. School of Education, Indiana University, Bloomington, Indiana, USA

    Sarah Hurwitz

  3. Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA

    Danielle Morriss

  4. Departments of Psychiatry and Pediatrics, Lurie Center for Autism, Massachusetts General Hospital and MassGeneral Hospital for Children, Harvard Medical School, One Maguire Road, Lexington, MA, 02421, USA

    Christopher J. McDougle

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Correspondence to Christopher J. McDougle.

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Minshawi, N.F., Hurwitz, S., Morriss, D. et al. Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach. J Autism Dev Disord 45, 1541–1568 (2015). https://doi.org/10.1007/s10803-014-2307-3

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