Abstract
Irritability is a transdiagnostic feature and a common mental health problem in adolescence. Prior studies indicate that irritability is composed of two correlated but separable dimensions, tonic irritability (i.e., irritable mood) and phasic irritability (i.e., temper outbursts), which are respectively associated with internalizing and externalizing outcomes. However, little is known about the stability and interrelations of tonic and phasic irritability. The current study examined the longitudinal interplay between tonic and phasic irritability during adolescence. A community sample of 544 girls (age 13.5–15.5 years) was assessed at 5 waves (over 3 years, in 9-month intervals). A random-intercept cross-lagged panel model was used to examine the within-person stability and longitudinal interrelations of tonic and phasic irritability. Pseudo-indicator models were used to help analyze all available data. Results suggest that tonic and phasic irritability had distinct patterns of development and co-development. Between individuals, tonic and phasic irritability showed moderate rank-order stability and high concurrent correlations. Within individuals, phasic irritability was found to positively predict both tonic and phasic irritability at the subsequent wave, whereas tonic irritability did not predict later phasic irritability and showed weaker within-person stability. These results suggest that increased or decreased phasic irritability in adolescent girls may signify continued increase or decrease in both tonic and phasic irritability. The study was among the first to demonstrate the discriminant validity of tonic and phasic irritability from a developmental perspective.
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Notes
In structural equation modeling, the baseline models are typically null models, where all variables of interest are included but they are not allowed to correlate. This baseline model serves as the comparison for the model fit by the researcher, and some fit indices are calculated based on the difference between the researcher’s model and the null model using the same data and variables. In SEMs that utilize the PIM, however, the standard baseline null model does not properly account for the PIMs and estimates a biased CFI and TLI, making it inadequate for characterizing model fit. Thus, following Rose et al. (2019), we parameterized an appropriate baseline model, which incorporated the features of PIMs for all 10 tonic and phasic irritability scale score variables to serve as a more appropriate baseline model. Syntax for our baseline model are provided in Appendix A.
References
Allison, P. (2009). Fixed Effects Regression Models. In. Retrieved from https://methods.sagepub.com/book/fixed-effects-regression-models doi:https://doi.org/10.4135/9781412993869
Azur, M. J., Stuart, E. A., Frangakis, C., & Leaf, P. J. (2011). Multiple imputation by chained equations: What is it and how does it work? International Journal Of Methods In Psychiatric Research, 20(1), 40–49. https://doi.org/10.1002/mpr.329.
Beauchaine, T. P., & Tackett, J. L. (2020). Irritability as a transdiagnostic vulnerability trait:Current issues and future directions. Behavior Therapy, 51(2), 350–364. https://doi.org/10.1016/j.beth.2019.10.009.
Berry, D., & Willoughby, M. T. (2017). On the practical interpretability of Cross-Lagged Panel Models: Rethinking a developmental workhorse. Child Development, 88(4), 1186–1206. https://doi.org/10.1111/cdev.12660.
Borghuis, J., Denissen, J. J. A., Oberski, D., Sijtsma, K., Meeus, W. H. J., Branje, S., & Bleidorn, W. (2017). Big five personality stability, change, and codevelopment across adolescence and early adulthood. J Pers Soc Psychol, 113(4), 641–657. https://doi.org/10.1037/pspp0000138.
Brotman, M. A., Schmajuk, M., Rich, B. A., Dickstein, D. P., Guyer, A. E., Costello, E. J., & Leibenluft, E. (2006). Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Biological Psychiatry, 60(9), 991–997. https://doi.org/10.1016/j.biopsych.2006.08.042.
Brotman, M. A., Kircanski, K., Stringaris, A., Pine, D. S., & Leibenluft, E. (2017). Irritability in Youths: A translational model. American Journal Of Psychiatry, 174(6), 520–532. https://doi.org/10.1176/appi.ajp.2016.16070839.
Burke, J. D. (2012). An affective dimension within oppositional defiant disorder symptoms among boys: Personality and psychopathology outcomes into early adulthood. Journal of Child Psychology and Psychiatry, 53(11), 1176–1183. https://doi.org/10.1111/j.1469-7610.2012.02598.x.
Burke, J. D., Hipwell, A. E., & Loeber, R. (2010). Dimensions of oppositional defiant disorder as predictors of depression and conduct disorder in preadolescent girls. Journal of the American Academy of Child & Adolescent Psychiatry, 49(5), 484–492. https://doi.org/10.1097/00004583-201005000-00009.
Burnham, K. P., & Anderson, D. R. (2004). Multimodel Inference:Understanding AIC and BIC in Model Selection. 33(2),261–304. doi:https://doi.org/10.1177/0049124104268644
Buss, A. H., & Perry, M. (1992). The aggression questionnaire. J Pers Soc Psychol, 63(3), 452–459. https://doi.org/10.1037//0022-3514.63.3.452.
Cardinale, E. M., Freitag, G. F., Brotman, M. A., Pine, D. S., Leibenluft, E., & Kircanski, K. (2021). Phasic Versus Tonic Irritability: Differential Associations with Attention-Deficit/Hyperactivity disorder symptoms. Journal Of The American Academy Of Child And Adolescent Psychiatry, 60(12), 1513–1523. https://doi.org/10.1016/j.jaac.2020.11.022.
Copeland, W. E., Angold, A., Costello, E. J., & Egger, H. (2013). Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder. American Journal Of Psychiatry, 170(2), 173–179. https://doi.org/10.1176/appi.ajp.2012.12010132.
Copeland, W. E., Brotman, M. A., & Costello, E. J. (2015). Normative irritability in Youth: Developmental Findings from the Great Smoky Mountains Study. Journal Of The American Academy Of Child And Adolescent Psychiatry, 54(8), 635–642. https://doi.org/10.1016/j.jaac.2015.05.008.
Evans, S. C., Burke, J. D., Roberts, M. C., Fite, P. J., Lochman, J. E., de la Pena, F. R., & Reed, G. M. (2017). Irritability in child and adolescent psychopathology: An integrative review for ICD-11. Clinical Psychology Review, 53, 29–45. https://doi.org/10.1016/j.cpr.2017.01.004.
Goldberg, L. R., Johnson, J. A., Eber, H. W., Hogan, R., Ashton, M. C., Cloninger, C. R., & Gough, H. G. J. J. o. R. i. p. (2006). The international personality item pool and the future of public-domain personality measures. 40(1), 84–96.
Goldstein, B. L., Kotov, R., Perlman, G., Watson, D., & Klein, D. N. (2018). Trait and facet-level predictors of first-onset depressive and anxiety disorders in a community sample of adolescent girls. Psychological Medicine, 48(8), 1282–1290. https://doi.org/10.1017/S0033291717002719.
Hamaker, E. L. RI-CLPM, standardization.
Hamaker, E. L., Kuiper, R. M., & Grasman, R. P. (2015). A critique of the cross-lagged panel model. Psychological Methods, 20(1), 102–116. https://doi.org/10.1037/a0038889.
Hankin, B. L., Abramson, L. Y., Moffitt, T. E., Silva, P. A., McGee, R., & Angell, K. E. (1998). Development of depression from preadolescence to young adulthood: Emerging gender differences in a 10-year longitudinal study. Journal Of Abnormal Psychology, 107(1), 128–140. https://doi.org/10.1037//0021-843x.107.1.128.
Hawes, M. T., Carlson, G. A., Finsaas, M. C., Olino, T. M., Seely, J. R., & Klein, D. N. (2020). Dimensions of irritability in adolescents: Longitudinal associations with psychopathology in adulthood. Psychological Medicine, 50(16), 2759–2767. https://doi.org/10.1017/S0033291719002903.
Hirsch, E., Davis, K., Cao, Z., & Roy, A. K. (2022). Understanding phasic irritability: Anger and distress in Children’s Temper Outbursts. Child Psychiatry And Human Development, 53(2), 317–329. https://doi.org/10.1007/s10578-021-01126-5.
Klein, D. N., Dougherty, L. R., Kessel, E. M., Silver, J., & Carlson, G. A. (2021). A transdiagnostic perspective on Youth Irritability. Current Directions In Psychological Science, 30(5), 437–443. https://doi.org/10.1177/09637214211035101.
Lewis, M. J. P. I. (2001). Issues in the study of personality development. 12(2),67–83.
Liu, Q., Nestor, B. A., & Cole, D. A. (2021). Differential associations of phasic and tonic irritability to suicidality among U.S. adults. Journal Of Affective Disorders, 292, 391–397. https://doi.org/10.1016/j.jad.2021.05.066.
Lüdtke, O., & Robitzsch, A. (2021). A critique of the random intercept cross-lagged panel model.
MacCallum, R. C., Zhang, S., Preacher, K. J., & Rucker, D. D. (2002). On the practice of dichotomization of quantitative variables. Psychological Methods, 7(1), 19–40. https://doi.org/10.1037/1082-989x.7.1.19.
Mattanah, J. J., Becker, D. F., Levy, K. N., Edell, W. S., & McGlashan, T. H. (1995). Diagnostic stability in adolescents followed up 2 years after hospitalization. American Journal Of Psychiatry, 152(6), 889–894. https://doi.org/10.1176/ajp.152.6.889.
McElroy, E., Shevlin, M., & Murphy, J. (2017). Internalizing and externalizing disorders in childhood and adolescence: A latent transition analysis using ALSPAC data. Compr Psychiatry, 75, 75–84. https://doi.org/10.1016/j.comppsych.2017.03.003.
Meyers, E., DeSerisy, M., & Roy, A. K. (2017). Disruptive Mood Dysregulation Disorder (DMDD): An RDoC perspective. Journal Of Affective Disorders, 216, 117–122. https://doi.org/10.1016/j.jad.2016.08.007.
Michelini, G., Perlman, G., Tian, Y., Mackin, D. M., Nelson, B. D., Klein, D. N., & Kotov, R. (2021). Multiple domains of risk factors for first onset of depression in adolescent girls. Journal Of Affective Disorders, 283, 20–29. https://doi.org/10.1016/j.jad.2021.01.036.
Moore, A. A., Lapato, D. M., Brotman, M. A., Leibenluft, E., Aggen, S. H., Hettema, J. M., & Roberson-Nay, R. (2019). Heritability, stability, and prevalence of tonic and phasic irritability as indicators of disruptive mood dysregulation disorder. Journal Of Child Psychology And Psychiatry, 60(9), 1032–1041. https://doi.org/10.1111/jcpp.13062.
Mund, M., Johnson, M. D., & Nestler, S. (2021). Changes in size and interpretation of parameter estimates in within-person models in the Presence of Time-Invariant and Time-Varying covariates. Frontiers In Psychology, 12, 666928. https://doi.org/10.3389/fpsyg.2021.666928.
Nelson, B. D., Perlman, G., Klein, D. N., Kotov, R., & Hajcak, G. (2016). Blunted neural response to rewards as a prospective predictor of the development of Depression in adolescent girls. American Journal Of Psychiatry, 173(12), 1223–1230. https://doi.org/10.1176/appi.ajp.2016.15121524.
Resche-Rigon, M., & White, I. R. (2018). Multiple imputation by chained equations for systematically and sporadically missing multilevel data. Statistical Methods In Medical Research, 27(6), 1634–1649. https://doi.org/10.1177/0962280216666564.
Richter, D., Körtner, J. L., & Saßenroth, D. (2014). Personality has minor effects on panel attrition. Journal of Research in Personality, 53, 31–35.
Rose, N., Wagner, W., Mayer, A., & Nagengast, B. J. C. P. (2019). Model-based manifest and latent composite scores in structural equation models. 5(1).
Rosseel, Y. J. J. o. s. s. (2012). lavaan: An R package for structural equation modeling. 48, 1–36.
Silver, J., Carlson, G. A., Olino, T. M., Perlman, G., Mackin, D., Kotov, R., & Klein, D. N. (2021). Differential outcomes of tonic and phasic irritability in adolescent girls. Journal Of Child Psychology And Psychiatry, 62(10), 1220–1227. https://doi.org/10.1111/jcpp.13402.
Silver, J., Bufferd, S. J., Dougherty, L. R., Goldstein, B. L., Carlson, G. A., & Klein, D. N. (2022a). Is the distinction between tonic and phasic irritability meaningful in 3-year-old children? European Child And Adolescent Psychiatry. 10.1007/s00787-022-01995-8.
Silver, J., Mackin, D. M., Bufferd, S. J., Dougherty, L. R., Goldstein, B. L., Carlson, G. A., & Klein, D. N. (2022b). Tonic and phasic irritability in 6-year-old children: Differential correlates and outcomes. Journal Of Child Psychology And Psychiatry. 10.1111/jcpp.13688.
Steinberg, L., & Morris, A. S. (2001). Adolescent development. Annu Rev Psychol, 52, 83–110. https://doi.org/10.1146/annurev.psych.52.1.83.
Stringaris, A., & Goodman, R. (2009a). Three dimensions of oppositionality in youth. Journal of Child Psychology and Psychiatry, 50(3), 216–223. 10.1111/j.1469-7610.2008.01989.x.
Stringaris, A., & Goodman, R. (2009b). Longitudinal outcome of youth oppositionality: Irritable, headstrong, and hurtful behaviors have distinctive predictions. Journal of the American Academy of Child & Adolescent Psychiatry, 48(4), 404–412. 10.1097/CHI.0b013e3181984f30.
Stringaris, A., Cohen, P., Pine, D. S., & Leibenluft, E. (2009). Adult outcomes of youth irritability: A 20-year prospective community-based study. American Journal Of Psychiatry, 166(9), 1048–1054. https://doi.org/10.1176/appi.ajp.2009.08121849.
Stringaris, A., Vidal-Ribas, P., Brotman, M. A., & Leibenluft, E. (2018). Practitioner review: Definition, recognition, and treatment challenges of irritability in young people. Journal Of Child Psychology And Psychiatry, 59(7), 721–739. https://doi.org/10.1111/jcpp.12823.
Vidal-Ribas, P. (2021). Editorial: Moving from Concept to Proof in the distinction between phasic and Tonic Irritability. Journal Of The American Academy Of Child And Adolescent Psychiatry, 60(12), 1464–1466. https://doi.org/10.1016/j.jaac.2021.02.002.
Wakschlag, L. S., Choi, S. W., Carter, A. S., Hullsiek, H., Burns, J., McCarthy, K., & Briggs-Gowan, M. J. (2012). Defining the developmental parameters of temper loss in early childhood: Implications for developmental psychopathology. Journal Of Child Psychology And Psychiatry, 53(11), 1099–1108. https://doi.org/10.1111/j.1469-7610.2012.02595.x.
Watson, D., Stasik, S. M., Chmielewski, M., & Naragon-Gainey, K. (2015). Development and validation of the temperament and affectivity inventory (TAI). Assessment, 22(5), 540–560. https://doi.org/10.1177/1073191114557943.
Whelan, Y. M., Stringaris, A., Maughan, B., & Barker, E. D. (2013). Developmental continuity of oppositional defiant disorder subdimensions at ages 8, 10, and 13 years and their distinct psychiatric outcomes at age 16 years. Journal of the American Academy of Child & Adolescent Psychiatry, 52(9), 961–969. https://doi.org/10.1016/j.jaac.2013.06.013.
Youngstrom, E., Loeber, R., & Stouthamer-Loeber, M. (2000). Patterns and correlates of agreement between parent, teacher, and male adolescent ratings of externalizing and internalizing problems. Journal Of Consulting And Clinical Psychology, 68(6), 1038–1050. https://doi.org/10.1037//0022-006x.68.6.1038.
Acknowledgements
This study was supported by National Institute of Mental Health grants R01MH093479 and R56MH117116 awarded to coauthors R.K. and D.N.K. The authors would like to thank all the dedicated research staff for their assistance on this project. A special thank you to all the participating adolescents and their families, without whom this research would not be possible.
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Conceptualization: [Yinghao Zhang], [Daniel N. Klein], [Nicholas R. Eaton], [Jamilah I. Silver]; Methodology: all authors; Formal analysis and investigation: [Yinghao Zhang]; Writing - original draft preparation: [Yinghao Zhang], [Jamilah I. Silver]; Writing - review and editing: all authors; Funding acquisition: [Roman Kotov], [Daniel N. Klein]; Resources: [Greg Perlman], [Roman Kotov], [Daniel N. Klein]; Supervision: [Nicholas R. Eaton]. All authors approved the final manuscript.
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Zhang, Y., Silver, J.I., Perlman, G. et al. Longitudinal Stability and Interrelations of Tonic and Phasic Irritability in Adolescent Girls. Res Child Adolesc Psychopathol 51, 1343–1355 (2023). https://doi.org/10.1007/s10802-023-01072-x
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DOI: https://doi.org/10.1007/s10802-023-01072-x