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Changes in retinal vascular density measured by optical coherence tomography angiography in patients with carotid artery stenosis after carotid artery stenting and angioplasty

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Abstract

Purpose

The aim of this study was to compare the effect of carotid artery stenting and angioplasty (CASA) on retinal vascular density (VD) in patients with severe carotid stenosis with a healthy control group and to evaluate using optical coherence tomography angiography (OCTA).

Methods

For this prospective study, eyes on the operated side constituted the ipsilateral eye group, and the other eye constituted the contralateral eye group. 40 eyes of 40 patients with ipsilateral eye of carotisid artery stenosis (CAS), 34 eyes on contralateral side, and 30 healthy eyes (control group) were included in this study. We performed quantitative OCTA analyses of retinal VD changes, before and after CASA. The main outcome measures were the quantitative changes of VD of superficial capillary plexus (SCP) and deep capillary plexus (DCP).

Results

We evaluated the VD of ipsilateral eyes and contralateral eyes separately before and after the procedure. All patients did not have visual symptoms. There was no significant difference in the VD of SCP in all groups before the procedure. No significant change was observed in all groups when the VD of the SCP was compared before and after the procedure. The VD of the DCP in the ipsilateral and contralateral group improved significantly after CASA.

Conclusion

OCTA could noninvasively detect retinal VD improvements after CASA in CAS patients. Quantitative changes in VD evaluated using OCTA are thought to be early indicators in the diagnosis of CAS and in the follow-up of treatment success.

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Acknowledgements

The authors did not receive any financial support for this study, and they have no conflicts of interest to declare.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. University of Health Sciences, Department of Ophthalmology, Basaksehir Cam and Sakura City Hospital, Basaksehir Olympic Boulevard Road Basaksehir, Istanbul, Turkey

    Murat Karapapak, Serhat Ermis, Petek Aksöz Bolat, Ece Özal & Sadık Altan Özal

  2. University of Health Sciences, Department of Interventional Radiology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey

    Mehmet Cingöz & Çağrı Erdim

Authors
  1. Murat Karapapak
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  2. Serhat Ermis
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  3. Petek Aksöz Bolat
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  4. Mehmet Cingöz
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  5. Çağrı Erdim
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  6. Ece Özal
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  7. Sadık Altan Özal
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Contributions

Writing: Murat Karapapak, MD, FICO; Serhat Ermiş, MD. Data Collection and Processing: Murat Karapapak, MD, FICO; Petek Aksöz, M.D. Examinations and Data Sharing: Mehmet Cingöz, MD; Çağrı Erdim, MD; Murat Karapapak, MD; Petek Aksöz, MD. Analysis and Interpretation: Murat Karapapak, MD, FICO; Ece Özal, MD; Sadık Altan Özal, MD, FEBO.

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Correspondence to Murat Karapapak.

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Karapapak, M., Ermis, S., Aksöz Bolat, P. et al. Changes in retinal vascular density measured by optical coherence tomography angiography in patients with carotid artery stenosis after carotid artery stenting and angioplasty. Int Ophthalmol 44, 128 (2024). https://doi.org/10.1007/s10792-024-03069-x

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  • DOI: https://doi.org/10.1007/s10792-024-03069-x

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