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Vision-related quality of life in patients with retinal vein occlusion

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Abstract

Purpose

This study aims to assess the vision-related quality of life in patients with retinal vein occlusion (RVO) among those referred to Labbafinejad Medical Center and Imam Hossein Hospital between 2019 and 2021.

Methods

This comparative study included 37 eligible patients diagnosed with various types of RVO, with an average age of 61 ± 9. To ensure data validity, we included 74 age- and sex-matched healthy individuals. Only cases with a definitive diagnosis of RVO, confirmed by two retina specialists (ND and RN), were included. We assessed the vision-related quality of life of our participants using the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25). All participants underwent interviews.

Results

In our study, we examined the vision-related quality of life in different subgroups of RVO patients. Overall, RVO patients had a significantly lower total VRQoL score compared to healthy individuals (P < 0.001), except in the subscale analysis of specific factors such as ocular pain, color vision, and driving, where no statistically significant difference was observed. A statistically significant difference was found in the comparison of subgroups, indicating lower VRQoL in central retinal vein occlusion (CRVO) patients (P = 0.010). Furthermore, a significant correlation was observed between lower VRQoL and decreased vision (P = 0.009) as well as longer disease duration (P = 0.011).

Conclusion

Retinal vein occlusion can significantly reduce vision-related quality of life, particularly in more severe cases.

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Availability of data and materials

The data generated or analyzed during this study are not included in this article but can be made available upon request from the corresponding author.

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Acknowledgements

The listed authors have approved all statements and declarations, including any conflicting interests, funding disclosures, etc.

Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Author notes

  1. Shahrokh Ramin and Fatemeh Rostami have contributed equally to this work.

Authors and Affiliations

  1. Department of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Shahrokh Ramin, Fatemeh Rostami & Hamideh Sabbaghi

  2. NanoBaran Lab, Incubation Center for Pharmaceutical Technology (ICPT), Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Shahrokh Ramin & Ali Abbasi

  3. Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamid Ahmadieh & Ramin Nourinia

  4. Experimental Medicine, Department of Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada

    Narsis Daftarian

  5. Department of Epidemiology and Biostatistics, School of Medicine and Dentistry, Western University, Ontario, Canada

    Bahareh Kheiri

  6. Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, 23 Paidar Fard, Bostan 9, Pasdaran Ave., Tehran, 16666, Iran

    Hamideh Sabbaghi

  7. Basir Eye Health Research Center, Iran University of Medical Sciences, Tehran, Iran

    Kourosh Sheibani

Authors
  1. Shahrokh Ramin
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Contributions

All authors contributed to the study's conception and design. Patient examinations were conducted by HS, SR, RN, ND, and HA. The manuscript was written by HS, FR, KS and SR. Data collection was carried out by HS, FR, and AA. Data analysis was performed by BK and KS. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Hamideh Sabbaghi.

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Conflict of interest

The authors declare no competing interests.

Ethics approval

All experimental protocols received approval from the Ethics Committee of the Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, under approval number IR.SBMU.ORC.REC.1400.007. All methods adhered to the guidelines and regulations outlined in the Declaration of Helsinki. Informed consent letters were obtained from all study participants, as well as from their parents or legal guardians. Participants were assured that their information would be kept confidential.

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Ramin, S., Rostami, F., Ahmadieh, H. et al. Vision-related quality of life in patients with retinal vein occlusion. Int Ophthalmol 44, 114 (2024). https://doi.org/10.1007/s10792-024-02916-1

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