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Assessment of retinal and choroidal vessel density and nerve fibre layer thickness changes after orbitotomy in patients with severe non-active thyroid orbitopathy: a prospective study

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Abstract

Purpose

To evaluate the optical coherence tomography angiogram changes in non-active severe thyroid-related ophthalmopathy patients after cosmetic bone decompression.

Methods

Eighteen patients (25 eyes) with severe not active not compressive (NANC) TED who were candidates for decompression surgery for cosmetic reasons were included in this study, and a 3 × 3 mm macular scan was used to measure vessel density and RNFL thickness. Whole macular vessel density in its superficial, deep and choriocapillaris layers was evaluated. The following data were extracted for each of layers: superior and inferior hemispheres, fovea, parafoveal vessel density, its superior and inferior hemispheres, and temporal, superior, nasal and inferior quadrant.

Results

The mean RPC increased postoperatively, which was statistically significant in small vessels of peripapillary area (p-value = 0.045). The mean RNFL thickness decreased after surgery and it was statistically significant in the peripapillary (p-value = 0.032) and Inferior-Hemifield area (p-value = 0.036). The choriocapillaris changes were significant in Superior-Hemifield (p-value = 0.031) and Fovea (p-value = 0.03).

Conclusion

Thyroid-associated orbitopathy patients have a tendency to decrease vascular density and correlated with disease activity more than stage of orbitopathy. There was not a strong and even discrepant result in linkage of RNFL thickness and other optic nerve function tests and TED patient status and it is needed to do studies with more epidemiologic power and same methodology of study to be more comparable.

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Abbreviations

DON:

Dysthyroid optic neuropathy

IOP:

Intraocular pressure

OCT-A:

Optical coherence tomography angiography

ONH:

Optic nerve head

NANC:

Not active not compressive

RNFL:

Retinal nerve fibre layer

RPC:

Radial peripapillary capillary

TED:

Thyroid eye disease

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Authors and Affiliations

  1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, 1336616351, Iran

    Mansoreh Jamshidian Tehrani, Hanieh Niktinat, Behzad Jafari, Seyed Mohsen Rafizadeh & Abolfazl Kasaee

  2. Ophthalmology Department, University of Florida, Gainesville, FL, USA

    Nazanin Ebrahimiadib

Authors
  1. Mansoreh Jamshidian Tehrani
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  2. Hanieh Niktinat
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  3. Nazanin Ebrahimiadib
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  4. Behzad Jafari
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  5. Seyed Mohsen Rafizadeh
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  6. Abolfazl Kasaee
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Contributions

Mansoreh Jamshidian Tehrani, Hanieh Niktinat, Nazanin Ebrahimiadib and Behzad Jafari wrote the main manuscript text . and Seyed Mohsen Rafizadeh and Abolfazl Kasaee, prepared figures and data analysis. . All authors reviewed the manuscript

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Correspondence to Abolfazl Kasaee.

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Jamshidian Tehrani, M., Niktinat, H., Ebrahimiadib, N. et al. Assessment of retinal and choroidal vessel density and nerve fibre layer thickness changes after orbitotomy in patients with severe non-active thyroid orbitopathy: a prospective study. Int Ophthalmol 43, 4427–4433 (2023). https://doi.org/10.1007/s10792-023-02790-3

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  • DOI: https://doi.org/10.1007/s10792-023-02790-3

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