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Comparison of the results of Ex-PRESS® surgery for primary open-angle glaucoma between high and low preoperative intraocular pressure

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Abstract

Purpose

To compare surgical outcomes of Ex-PRESS® (EXP) surgery for primary open-angle glaucoma (POAG) between low preoperative intraocular pressure (IOP) and high preoperative IOP.

Methods

This was a retrospective non-randomized study. Seventy-nine POAG patients who underwent EXP surgery and were followed for > 3 years were included. Patients with a preoperative IOP of ≦ 16 mmHg and > 16 mmHg with tolerant glaucoma medications were defined as the low IOP group and the high IOP group, respectively. We compared the surgical outcomes, postoperative IOP and number of glaucoma medications. Success was defined as a postoperative IOP of ≦ 15 mmHg and a reduction of > 20% from the preoperative IOP to the postoperative IOP.

Results

EXP surgeries significantly decreased IOPs from 13.2 ± 2.0 to 9.1 ± 2.9 mmHg in the low IOP group (p < 0.001), and from 22.5 ± 4.8 to 12.5 ± 4.0 mmHg in the high IOP group (p < 0.001). The mean postoperative IOP was significantly low in the low IOP group at 3 years (p = 0.0008). Success rates compared using the Kaplan–Meier survival curve were not significantly different (p = 0.449).

Conclusions

EXP surgery was useful for POAG patients with a low preoperative IOP.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Noriko Katayama, Naoki Tojo, Mitsuya Otsuka & Atsushi Hayashi

Authors
  1. Noriko Katayama
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  2. Naoki Tojo
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  3. Mitsuya Otsuka
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  4. Atsushi Hayashi
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Mitsuya Otsuka, Noriko Katayama and Naoki Tojo. The first draft of the manuscript was written by Noriko Katayama and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Naoki Tojo.

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The authors declare no competing interests.

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The authors have no relevant financial or non-financial interests to disclose.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Toyama University.

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Katayama, N., Tojo, N., Otsuka, M. et al. Comparison of the results of Ex-PRESS® surgery for primary open-angle glaucoma between high and low preoperative intraocular pressure. Int Ophthalmol 43, 2803–2809 (2023). https://doi.org/10.1007/s10792-023-02678-2

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  • DOI: https://doi.org/10.1007/s10792-023-02678-2

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